Trine Tramm

Ph.D, Klinisk lektor

Trine Tramm
Overlæge, Ph.D
Patologi
Aarhus Universitetshospital
Palle Juul-Jensens Boulebard 99, C112
8200 Aarhus N
Danmark
E-mail: tramm@oncology.au.dk

Publikationer

Aquaporin-5 in breast cancer

Bystrup, M., Login, F. H., E, S., Borgquist, S., Tramm, T., Kwon, T-H. & Nejsum, L. N., maj 2022, I: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 130, 5, s. 253-260

Diagnostic accuracy of radiography, digital breast tomosynthesis, micro-CT and ultrasound for margin assessment during breast surgery: A systematic review and meta-analysis

Palimaru Manhoobi, I., Bodilsen, A., Nijkamp, J. A., Pareek, A., Tramm, T., Redsted, S. & Christiansen, P. M., 4 jan. 2022, (Accepteret/In press) I: Academic Radiology.

Aquaporin-1 in breast cancer

Traberg-Nyborg, L., Login, F. H., E, S., Tramm, T., Borgquist, S. & Nejsum, L. N., jan. 2022, I: APMIS - Journal of Pathology, Microbiology and Immunology. 130, 1, s. 3-10 8 s.

Hypoxic gene expression is a prognostic factor for disease free survival in a cohort of locally advanced squamous cell cancer of the uterine cervix

Alsner, J., Overgaard, J., Tramm, T. & Lindegaard, J. C., 2022, I: Acta Oncologica. 61, 2, s. 172-178 7 s.

Tumor-infiltrating lymphocytes predict improved overall survival after post-mastectomy radiotherapy: a study of the randomized DBCG82bc cohort

Tramm, T., Vinter, H., Vahl, P., Özcan, D., Alsner, J. & Overgaard, J., 2022, I: Acta Oncologica. 61, 2, s. 153-162 10 s.

Can evaluation of mismatch repair defect and TILs increase the number of triple-negative breast cancer patients eligible for immunotherapy?

Özcan, D., Lade-Keller, J. & Tramm, T., okt. 2021, I: Pathology Research and Practice. 226, 6 s., 153606.

Digital image analysis is a robust method for evaluation of tumour- associated macrophages in breast cancer

Nielsen, K. H. L., Nielsen, P. S. & Tramm, T., 29 aug. 2021.

Digital image analysis is a robust method for evaluation of tumor-associated macrophages in breast cancer

Nielsen, K. H. L., Nielsen, P. S. & Tramm, T., aug. 2021, I: Virchows Archiv. 479, S1, s. 83 1 s., PS-02-024.

Intraoperative digital breast tomosynthesis (DBT) of lumpectomy and its impact on reoperation rate in breast conserving surgery

Palimaru Manhoobi, I., Bodilsen, A., Redsted, S., Tramm, T. & Christiansen, P. M., aug. 2021. 1 s.

Superficial margins in skin sparing and nipple sparing mastectomies for DCIS: A margin of potential concern

Tramm, T., Christiansen, P., Offersen, B. V., Madsen, K. B., Poortmans, P. & Kaidar-Person, O., aug. 2021, I: Radiotherapy and Oncology. 161, s. 177-182 6 s.

A multidisciplinary approach for autologous breast reconstruction: A narrative (re)view for better management

Kaidar-Person, O., Hermann, N., Poortmans, P., Offersen, B. V., Boersma, L. J., de Ruysscher, D., Tramm, T., Kühn, T., Engberg Damsgaard, T., Gentilini, O., Maarse, W., Sklair-Levi, M. & Mátrai, Z., apr. 2021, I: Radiotherapy and Oncology. 157, s. 263-271 9 s.

A multidisciplinary view of mastectomy and breast reconstruction: Understanding the challenges

Kaidar-Person, O., Offersen, B. V., Boersma, L. J., de Ruysscher, D., Tramm, T., Kühn, T., Gentilini, O., Mátrai, Z. & Poortmans, P., apr. 2021, I: Breast. 56, s. 42-52 11 s.

Validation of an algorithm to ascertain late breast cancer recurrence using danish medical registries

Pedersen, R. N., Öztürk, B., Mellemkjær, L., Friis, S., Tramm, T., Nørgaard, M. & Cronin-Fenton, D. P., okt. 2020, I: Clinical epidemiology. 12, s. 1083-1093 11 s.

Artificial Intelligence-Facilitated Quantification of Immunoprofile in Breast Cancer Using 4-Plexed Chromogenic Immunohistochemistry

Nielsen, P. S., Georgsen, J. B., Steiniche, T. & Tramm, T., 18 sep. 2020, I: Journal of Pathology Informatics. 11, 30, s. S5 1 s.

Metabolic pathway analysis and effectiveness of tamoxifen in Danish breast cancer patients

Ahern, T. P., Collin, L. J., Baurley, J. W., Kjærsgaard, A., Nash, R., Maliniak, M. L., Damkier, P., Zwick, M. E., Isett, R. B., Christiansen, P. M., Ejlertsen, B., Lauridsen, K. L., Christensen, K. B., Silliman, R. A., Toft Sorensen, H., Tramm, T., Hamilton-Dutoit, S., Lash, T. L. & Cronin Fenton, D., mar. 2020, I: Cancer Epidemiology, Biomarkers & Prevention. 29, 3, s. 582-590

Calcium electroporation of equine sarcoids

Frandsen, S. K., Gehl, J., Tramm, T. & Thoefner, M. S., 2020, I: Animals. 10, 3, 12 s., 517.

Inflammatory breast cancer: A review from our experience

Mele, M., Sørensen, A. S., Bruun, J., Funder, J. A., Tramm, T., Bodilsen, A., Nielsen, H. M. & Christiansen, P. M., 2019, I: Breast Disease. 38, 2, s. 47-55 9 s.

Influence of intra-tumoral heterogeneity on the evaluation of BCL2, E-cadherin, EGFR, EMMPRIN, and Ki-67 expression in tissue microarrays from breast cancer

Tramm, T., Kyndi, M., Sørensen, F. B., Overgaard, J. & Alsner, J., jan. 2018, I: Acta Oncologica. 57, 1, s. 102-106 5 s.

Intrinsic subtypes and benefit from postmastectomy radiotherapy in node-positive premenopausal breast cancer patients who received adjuvant chemotherapy - results from two independent randomized trials

Laurberg, T., Tramm, T., Nielsen, T., Alsner, J., Nord, S., Myhre, S., Sørlie, T., Leung, S., Fan, C., Perou, C., Gelmon, K., Overgaard, J., Voduc, D., Prat, A. & Cheang, M. C. U., jan. 2018, I: Acta Oncologica. 57, 1, s. 38-43 6 s.

Standardized assessment of tumor-infiltrating lymphocytes in breast cancer: an evaluation of inter-observer agreement between pathologists

Scientific Committee of Pathology, Danish Breast Cancer Group (DBCG), jan. 2018, I: Acta Oncologica. 57, 1, s. 90-94 5 s.

Tumour-infiltrating lymphocytes predicts improved overall survival after post-mastectomy radiotherapy

Tramm, T., Vinter, H., Alsner, J. & Overgaard, J., 2018, I: Radiotherapy & Oncology. 127, s. S312-S313 2 s., OC-0597.

Normal and Malignant Cells Exhibit Differential Responses to Calcium Electroporation

Frandsen, S. K., Kruger, M. B., Mangalanathan, U. M., Tramm, T., Mahmood, F., Novak, I. & Gehl, J., 15 aug. 2017, I: Cancer Research. 77, 16, s. 4389-4401 13 s.

Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome

Aure, M. R., Vitelli, V., Jernström, S., Kumar, S., Krohn, M., Due, E. U., Haukaas, T. H., Leivonen, S-K., Vollan, H. K. M., Lüders, T., Rødland, E., Vaske, C. J., Zhao, W., Møller, E. K., Nord, S., Giskeødegård, G. F., Bathen, T. F., Caldas, C., Tramm, T., Alsner, J., Overgaard, J., Geisler, J., Bukholm, I. R. K., Naume, B., Schlichting, E., Sauer, T., Mills, G. B., Kåresen, R., Mælandsmo, G. M., Lingjærde, O. C., Frigessi, A., Kristensen, V. N., Børresen-Dale, A-L., Sahlberg, K. K. & OSBREAC, 29 mar. 2017, I: Breast Cancer Research. 19, 1, 18 s., 44.

Impact of age, intrinsic subtype and local treatment on long-term local-regional recurrence and breast cancer mortality among low-risk breast cancer patients

Laurberg, T., Alsner, J., Tramm, T., Jensen, V., Lyngholm, C. D., Christiansen, P. M. & Overgaard, J., jan. 2017, I: Acta Oncologica. 56, 1, s. 59-67 9 s.

Validation of a 15-gene hypoxia classifier in head and neck cancer for prospective use in clinical trials

Toustrup, K., Sørensen, B. S., Metwally, M. A. H., Tramm, T., Mortensen, L. S., Overgaard, J. & Alsner, J., 10 maj 2016, I: Acta Oncologica. 55, 9-10, s. 1091-1098 8 s.

Prognostic value of hypoxia-regulated gene expression in loco-regional gastroesophageal cancer

Winther, M., Alsner, J., Tramm, T., Holtved, E., Baeksgaard, L. & Nordsmark, M., maj 2016, I: Acta Oncologica. 55, 5, s. 652-5 4 s.

Hypoxia-regulated microRNAs in gastroesophageal cancer

Winther, M., Alsner, J., Sørensen, B. S., Wittrup, C. F., Tramm, T., Beaksgaard, L., Hofland, K., Holtved, E. & Nordsmark, M., feb. 2016, I: Anticancer Research. 36, 2, s. 721-30 10 s.

Clinical Impact of a Novel MicroRNA Chemo-Sensitivity Predictor in Gastrooesophageal Cancer

Winther, M., Knudsen, S., Dahlgaard, J., Jensen, T., Hansen, A., Jensen, P. B., Tramm, T., Alsner, J. & Nordsmark, M., 2016, I: P L o S One. 11, 2, 8 s., e0148070.

PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma

Thomsen, J., Hjortebjerg, R., Espelund, U., Ørtoft, G., Vestergaard, P., Magnusson, N. E., Conover, C. A., Tramm, T., Hager, H., Høgdall, C., Høgdall, E., Oxvig, C. & Frystyk, J., 24 aug. 2015, I: OncoTarget. 6, 31, s. 32266-32278 13 s.

Evaluation of miR-21 and miR-375 as prognostic biomarkers in esophageal cancer

Winther, M., Alsner, J., Tramm, T., Baeksgaard, L., Holtved, E. & Nordsmark, M., 2015, I: Acta Oncologica. 54, 9, s. 1582-91 10 s.

Molecular signatures of local control in breast cancer

Tramm, T. & Overgaard, J., 2015, I: Breast Diseases; A Year Book Quarterly. 26, 1, s. 16-18 3 s.

Development and validation of a gene profile predicting benefit of postmastectomy radiotherapy in patients with high-risk breast cancer: a study of gene expression in the DBCG82bc cohort

Tramm, T., Mohammed, H., Myhre, S., Kyndi, M., Alsner, J., Børresen-Dale, A-L., Sørlie, T., Frigessi, A. & Overgaard, J., 15 okt. 2014, I: Clinical Cancer Research. 20, 20, s. 5272-80 9 s.

Relationship between the prognostic and predictive value of the intrinsic subtypes and a validated gene profile predictive of loco-regional control and benefit from post-mastectomy radiotherapy in patients with high-risk breast cancer

Tramm, T., Kyndi, M., Myhre, S., Nord, S., Alsner, J., Sørensen, F. B., Sørlie, T. & Overgaard, J., okt. 2014, I: Acta Oncologica. 53, 10, s. 1337-46 10 s.

The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors

Quigley, D. A., Fiorito, E., Nord, S., Van Loo, P., Alnæs, G. G., Fleischer, T., Tost, J., Moen Vollan, H. K., Tramm, T., Overgaard, J., Bukholm, I. R., Hurtado, A., Balmain, A., Børresen-Dale, A-L. & Kristensen, V., mar. 2014, I: Molecular Oncology. s. 273-84 12 s.

Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c

Nygren, M. K., Tekle, C., Ingebrigtsen, V. A., Mäkelä, R., Krohn, M., Aure, M. R., Nunes-Xavier, C. E., Perälä, M., Tramm, T., Alsner, J., Overgaard, J., Nesland, J. M., Borgen, E., Børresen-Dale, A. L., Fodstad, O., Sahlberg, K. K. & Leivonen, S. K., 1 jan. 2014, I: B J C. 110, 8, s. 2072-2080 9 s.

Reliable PCR quantitation of estrogen, progesterone and ERBB2 receptor mRNA from formalin-fixed, paraffin-embedded tissue is independent of prior macro-dissection

Tramm, T., Hennig, G., Kyndi, M., Alsner, J., Sørensen, F. B., Myhre, S., Sørlie, T. & Overgaard, J., dec. 2013, I: Virchows Archiv. 463, 6, s. 775-786 12 s.

Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors

Aure, M. R., Leivonen, S-K., Fleischer, T., Zhu, Q., Overgaard, J., Alsner, J., Tramm, T., Louhimo, R., Alnæs, G. I., Perälä, M., Busato, F., Touleimat, N., Tost, J., Børresen-Dale, A-L., Hautaniemi, S., Troyanskaya, O. G., Lingjærde, O. C., Sahlberg, K. K. & Kristensen, V. N., 20 nov. 2013, I: Genome Biology. 14, 11, 20 s., R126.

Hypoxia-regulated gene expression and prognosis in loco-regional gastroesophageal cancer

Winther, M., Alsner, J., Tramm, T. & Nordsmark, M., okt. 2013, I: Acta Oncologica. 52, 7, s. 1327-1335 9 s.

Optimal reference genes for normalization of qRT-PCR data from archival formalin-fixed, paraffin-embedded breast tumors controlling for tumor cell content and decay of mRNA

Tramm, T., Sørensen, B. S., Overgaard, J. & Alsner, J., sep. 2013, I: Diagnostic Molecular Pathology. 22, 3, s. 181-187 7 s.

Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins

Myhre, S., Lingjærde, O-C., Hennessy, B. T., Aure, M. R., Carey, M. S., Alsner, J., Tramm, T., Overgaard, J., Mills, G. B., Børresen-Dale, A-L. & Sørlie, T., jun. 2013, I: Molecular Oncology. 7, 3, s. 704-18 15 s.

Tracheopathia osteochondroplastica - once seen, never forgotten: Tracheopathia osteochondroplastica - once seen, never forgotten

Stilling, C., Tramm, T., Bærentzen, S. & Hamilton-Dutoit, S. J., 1 mar. 2012. 1 s.

Tracheopathia osteochondroplastica - once seen, never forgotten: Tracheopathia osteochondroplastica - once seen, never forgotten

Stilling, C., Tramm, T., Bærentzen, S. & Hamilton-Dutoit, S. J., 1 mar. 2012, I: APMIS Supplementum. 120, 134, s. 32-32 1 s., 120.

Direct therapeutic applications of calcium electroporation to effectively induce tumor necrosis

Frandsen, S. K., Gissel, H., Hojman, P., Tramm, T., Eriksen, J. & Gehl, J., 26 jan. 2012, I: Cancer Research. 72, 6, s. 1336-1341

Breast irradiation profile. A gene expression signature predicting benefit of radiation therapy in breast cancer patients

Alsner, J., Tramm, T., Børresen-Dale, A. L., Frigessi, A., Mohammed, H., Myhre, S., Sørlie, T. & Overgaard, J., 2012, (Afsendt) IPC nr. U.S. Provisional Patent Application Serial No. 61/607,316

Combretastatin A-4 phosphate affects tumor vessel volume and size distribution as assessed using MRI-based vessel size imaging

Nielsen, T., Bentzen, L., Pedersen, M. N., Tramm, T., Rijken, P. F. J. W., Bussink, J., Horsman, M. R. & Østergaard, L., 2012, I: Clinical Cancer Research. 18, 23, s. 6469-77 9 s.

Diminished number or complete loss of myoepithelial cells associated with metaplastic and neoplastic apocrine lesions of the breast

Tramm, T., Kim, J-Y. & Tavassoli, F. A., 2011, I: American Journal of Surgical Pathology. 35, 2, s. 202-11 10 s.

In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome

Myhre, S., Mohammed, H., Tramm, T., Alsner, J., Finak, G., Park, M., Overgaard, J., Børresen-Dale, A-L., Frigessi, A. & Sørlie, T., 1 dec. 2010, I: P L o S One. 5, 11, s. e14002

HPV-associated p16-expression and response to hypoxic modification of radiotherapy in head and neck cancer

Lassen, P., Eriksen, J. G., Hamilton-Dutoit, S., Tramm, T., Alsner, J. & Overgaard, J., 2010, I: Radiotherapy & Oncology. 94, 1, s. 30-5 6 s.

Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck

Lassen, P., Eriksen, J. G., Hamilton-Dutoit, S., Tramm, T., Alsner, J. & Overgaard, J., 20 apr. 2009, I: Journal of Clinical Oncology. 27, 12, s. 1992-8 7 s.

Expression of EGFR and HPV-associated p16 in head and neck cancer: correlation and influence on prognosis after radiotherapy in 1088 patients from the randomised DAHANCA 5, 6 & 7 trials

Lassen, P., Eriksen, J. G., Tramm, T., Hamilton-Dutoit, S. J., Alsner, J. & Overgaard, J., 2009, I: EJC SUPPLEMENTS. 7, 2, s. 470 1 s.

Imaging tumor hypxia: The need to combine techniques.

Horsman, M. R., Nielsen, T., Østergaard, L., Tramm, T. & Busk, M., 2009. 1 s.

Inter-observer variability of HER2/neu expression evaluated by immunohistochemistry (Hercep Test).

Tramm, T., Daugaard, S., Rank, F. & Sørensen, FB., 2009. 1 s.

Interobserver variability of HER2/neu expression evaluated by immunohistochemistry (HercepTest).

Tramm, T., Jensen, V., Daugaard, S., Rank, F. & Sørensen, F. B., 2009.

Lipomatosis and xanthomatosis - unusual presentations in the normal bowel wall.

Horskær Madsen, S., Tramm, T. & Dybdahl, H., 2009, (Afsendt). 1 s.

Prognosis of Distant Metastasis in Node-Negative Early Breast Cancer

Schmidt, M., Tramm, T., Böhm, D., Kyndi, M., Alsner, J., Kölbi, H., Stropp, U., von Törne, C., Weber, K., Henning, G., Gehrmann, M., Sampson, E. & Overgaard, J., 2009. 1 s.

Robust PCR-quantification of RNA of mRNA extracted from 15 year old formalin fixed, paraffin embedded breast cancer tissue with variable tumor cell content.

Tramm, T., 2009, I: Journal of Molecular Diagnostics. 6

Skip Lesion of DIN (DCIS) in the Nipple in a Case of Breast Cancer

Tramm, T., Zuckerman, K. & Tavassoli, F. A., 2009, I: International Journal of Surgical Pathology. 19, 6, s. 817-21 5 s.

Quality control of diagnostic sensitivity in the histopathological examination of axillary lymph nodes in breast cancer.

Tramm, T., Vahl, P., Buhl, L., Brandt Sørensen, F. & Melsen (død), F., 2008, (Afsendt).

Verrucous Carcinoma of the Esophagus. 3 case stories

Kruse, A., Tramm, T. & Dybdahl, H., 2008.

HP-associated Verrucous Carcinoma of the Esophagus

Tramm, T., Kruse, A. & Dybdahl, H., 2007, I: Acta Pathologica Microbiologica et Immunologica Scandinavica. 115, 3, s. 272-273 2 s.

Hyperplastisk polypose i colon

Tramm, T., 2006.

Authorizations: 2014: Authorization as a Pathologist, National Board of Health, Denmark 2004: Permission to Practice independently as a Physician, National Board of Health, Denmark 2001: Authorization as a Physician, National Board of Health, Denmark

Leadership:
Member of DBCGs (Danish Breast Cancer Cooperative Group) Pathology group (2015-)
President of FYPA (Association of Young Pathologists in Denmark)(2011-2013)
Boardmember of DPAS (Danish Pathology Society) (2011-2013)
Boardmember of the IT commitee under DPAS (2011-2013)
Board member of FYPA (2009-2011)

Honours:
“Young Researcher of the Year - 2010” appointed by DSPAC (Danish Society of Pathology and Cytology)
Patents:
“Gene signatures associated with efficacy of postmastectomy radiotherapy in breast cancer “
Patent no. WO2013132354 (A2)