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Tove Christensen

The role of EBV in MS pathogenesis

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The role of EBV in MS pathogenesis. / Christensen, Tove.

I: Int MS J, Bind 13, 2006, s. 52-7.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Christensen, T 2006, 'The role of EBV in MS pathogenesis', Int MS J, bind 13, s. 52-7.

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Author

Christensen, Tove. / The role of EBV in MS pathogenesis. I: Int MS J. 2006 ; Bind 13. s. 52-7.

Bibtex

@article{bddade707af711dbbee902004c4f4f50,
title = "The role of EBV in MS pathogenesis",
abstract = "Environmental factors operate on a background of genetic susceptibility in the pathogenesis of MS. Human herpesviruses, notably Epstein-Barr virus (EBV), and human endogenous retroviruses are factors associated with MS. EBV association is found in epidemiological surveys where late EBV infection confers a higher risk of MS, and EBV reactivation also appears to be linked to disease activity in early MS. MS patients have elevated anti-EBV antibody responses, both in serum and cerebrospinal fluid. Molecular mimicry is found between certain EBV and myelin epitopes in the cell-mediated immune response. EBV cannot stand alone as a causal factor of MS, but is likely to play an indirect role as an activator of the underlying disease process.",
author = "Tove Christensen",
year = "2006",
language = "English",
volume = "13",
pages = "52--7",
journal = "Int MS J",

}

RIS

TY - JOUR

T1 - The role of EBV in MS pathogenesis

AU - Christensen, Tove

PY - 2006

Y1 - 2006

N2 - Environmental factors operate on a background of genetic susceptibility in the pathogenesis of MS. Human herpesviruses, notably Epstein-Barr virus (EBV), and human endogenous retroviruses are factors associated with MS. EBV association is found in epidemiological surveys where late EBV infection confers a higher risk of MS, and EBV reactivation also appears to be linked to disease activity in early MS. MS patients have elevated anti-EBV antibody responses, both in serum and cerebrospinal fluid. Molecular mimicry is found between certain EBV and myelin epitopes in the cell-mediated immune response. EBV cannot stand alone as a causal factor of MS, but is likely to play an indirect role as an activator of the underlying disease process.

AB - Environmental factors operate on a background of genetic susceptibility in the pathogenesis of MS. Human herpesviruses, notably Epstein-Barr virus (EBV), and human endogenous retroviruses are factors associated with MS. EBV association is found in epidemiological surveys where late EBV infection confers a higher risk of MS, and EBV reactivation also appears to be linked to disease activity in early MS. MS patients have elevated anti-EBV antibody responses, both in serum and cerebrospinal fluid. Molecular mimicry is found between certain EBV and myelin epitopes in the cell-mediated immune response. EBV cannot stand alone as a causal factor of MS, but is likely to play an indirect role as an activator of the underlying disease process.

M3 - Journal article

VL - 13

SP - 52

EP - 57

JO - Int MS J

JF - Int MS J

ER -