Institut for Biomedicin

Tove Christensen

The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1. / Nexø, Bjørn Andersen; Christensen, Tove; Frederiksen, Jette; Møller-Larsen, Anné; Oturai, Annette Bang; Villesen, Palle; Hansen, Bettina; Nissen, Kari K; Laska, Magdalena J; Petersen, Trine Skov; Bonnesen, Sandra; Hedemand, Anne; Wu, Tingting; Wang, Xinjie; Zhang, Xiuqing; Brudek, Tomasz; Maric, Romana; Søndergaard, Helle; Sellebjerg, Finn Thorup; Brusgaard, Klaus; Kjeldbjerg, Anders L; Rasmussen, Henrik B; Nielsen, Anders L; Nyegaard, Mette; Petersen, Thor; Børglum, Anders D; Pedersen, Finn S.

I: P L o S One, Bind 6, Nr. 2, 01.01.2011, s. e16652.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Nexø, BA, Christensen, T, Frederiksen, J, Møller-Larsen, A, Oturai, AB, Villesen, P, Hansen, B, Nissen, KK, Laska, MJ, Petersen, TS, Bonnesen, S, Hedemand, A, Wu, T, Wang, X, Zhang, X, Brudek, T, Maric, R, Søndergaard, H, Sellebjerg, FT, Brusgaard, K, Kjeldbjerg, AL, Rasmussen, HB, Nielsen, AL, Nyegaard, M, Petersen, T, Børglum, AD & Pedersen, FS 2011, 'The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1', P L o S One, bind 6, nr. 2, s. e16652. https://doi.org/10.1371/journal.pone.0016652

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Author

Nexø, Bjørn Andersen ; Christensen, Tove ; Frederiksen, Jette ; Møller-Larsen, Anné ; Oturai, Annette Bang ; Villesen, Palle ; Hansen, Bettina ; Nissen, Kari K ; Laska, Magdalena J ; Petersen, Trine Skov ; Bonnesen, Sandra ; Hedemand, Anne ; Wu, Tingting ; Wang, Xinjie ; Zhang, Xiuqing ; Brudek, Tomasz ; Maric, Romana ; Søndergaard, Helle ; Sellebjerg, Finn Thorup ; Brusgaard, Klaus ; Kjeldbjerg, Anders L ; Rasmussen, Henrik B ; Nielsen, Anders L ; Nyegaard, Mette ; Petersen, Thor ; Børglum, Anders D ; Pedersen, Finn S. / The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1. I: P L o S One. 2011 ; Bind 6, Nr. 2. s. e16652.

Bibtex

@article{d7181b6cffd5493e88a6cfbac088f614,
title = "The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1",
abstract = "We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.",
author = "Nex{\o}, {Bj{\o}rn Andersen} and Tove Christensen and Jette Frederiksen and Ann{\'e} M{\o}ller-Larsen and Oturai, {Annette Bang} and Palle Villesen and Bettina Hansen and Nissen, {Kari K} and Laska, {Magdalena J} and Petersen, {Trine Skov} and Sandra Bonnesen and Anne Hedemand and Tingting Wu and Xinjie Wang and Xiuqing Zhang and Tomasz Brudek and Romana Maric and Helle S{\o}ndergaard and Sellebjerg, {Finn Thorup} and Klaus Brusgaard and Kjeldbjerg, {Anders L} and Rasmussen, {Henrik B} and Nielsen, {Anders L} and Mette Nyegaard and Thor Petersen and B{\o}rglum, {Anders D} and Pedersen, {Finn S}",
year = "2011",
month = jan,
day = "1",
doi = "10.1371/journal.pone.0016652",
language = "English",
volume = "6",
pages = "e16652",
journal = "P L o S One",
issn = "1932-6203",
publisher = "public library of science",
number = "2",

}

RIS

TY - JOUR

T1 - The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1

AU - Nexø, Bjørn Andersen

AU - Christensen, Tove

AU - Frederiksen, Jette

AU - Møller-Larsen, Anné

AU - Oturai, Annette Bang

AU - Villesen, Palle

AU - Hansen, Bettina

AU - Nissen, Kari K

AU - Laska, Magdalena J

AU - Petersen, Trine Skov

AU - Bonnesen, Sandra

AU - Hedemand, Anne

AU - Wu, Tingting

AU - Wang, Xinjie

AU - Zhang, Xiuqing

AU - Brudek, Tomasz

AU - Maric, Romana

AU - Søndergaard, Helle

AU - Sellebjerg, Finn Thorup

AU - Brusgaard, Klaus

AU - Kjeldbjerg, Anders L

AU - Rasmussen, Henrik B

AU - Nielsen, Anders L

AU - Nyegaard, Mette

AU - Petersen, Thor

AU - Børglum, Anders D

AU - Pedersen, Finn S

PY - 2011/1/1

Y1 - 2011/1/1

N2 - We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

AB - We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

U2 - 10.1371/journal.pone.0016652

DO - 10.1371/journal.pone.0016652

M3 - Journal article

C2 - 21311761

VL - 6

SP - e16652

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 2

ER -