Institut for Biomedicin

Tove Christensen

Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active Multiple Sclerosis

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Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active Multiple Sclerosis. / Laska, Magdalena Janina; Brudek, Tomasz; Nissen, Kari Konstantin; Christensen, Tove; Møller-Larsen, Anné; Petersen, Thor; Nexø, Bjørn Andersen.

I: Journal of Virology, Bind 86, 2012, s. 3713-22.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{89012aca92c74d419249113cae344309,
title = "Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active Multiple Sclerosis",
abstract = "Multiple Sclerosis (MS) is considered to be an autoimmune disease with unknown cause and with immune system dysregulation. Among environmental factors, viruses are most often connected with the etiology of MS.Human Endogenous Retroviruses (HERVs) constitute 5-8% of human genomic DNA and have been detected as transcripts and proteins in the central nervous system (CNS) and peripheral blood, frequently in the context of neuroinflammation. The HERV-Fc1, which belongs to the HERV-H/F family, has received our attention largely because of the genetic association with MS.The authors studied the expression of a capsid (Gag) protein of HERV-H/F origin by flow cytometry in PBMCs from healthy controls and from MS patients with non-active or active disease. There was a significant increase in HERV-H/F Gag expression in CD4+ (P",
author = "Laska, {Magdalena Janina} and Tomasz Brudek and Nissen, {Kari Konstantin} and Tove Christensen and Ann{\'e} M{\o}ller-Larsen and Thor Petersen and Nex{\o}, {Bj{\o}rn Andersen}",
year = "2012",
doi = "10.1128/JVI.06723-11",
language = "English",
volume = "86",
pages = "3713--22",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",

}

RIS

TY - JOUR

T1 - Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active Multiple Sclerosis

AU - Laska, Magdalena Janina

AU - Brudek, Tomasz

AU - Nissen, Kari Konstantin

AU - Christensen, Tove

AU - Møller-Larsen, Anné

AU - Petersen, Thor

AU - Nexø, Bjørn Andersen

PY - 2012

Y1 - 2012

N2 - Multiple Sclerosis (MS) is considered to be an autoimmune disease with unknown cause and with immune system dysregulation. Among environmental factors, viruses are most often connected with the etiology of MS.Human Endogenous Retroviruses (HERVs) constitute 5-8% of human genomic DNA and have been detected as transcripts and proteins in the central nervous system (CNS) and peripheral blood, frequently in the context of neuroinflammation. The HERV-Fc1, which belongs to the HERV-H/F family, has received our attention largely because of the genetic association with MS.The authors studied the expression of a capsid (Gag) protein of HERV-H/F origin by flow cytometry in PBMCs from healthy controls and from MS patients with non-active or active disease. There was a significant increase in HERV-H/F Gag expression in CD4+ (P

AB - Multiple Sclerosis (MS) is considered to be an autoimmune disease with unknown cause and with immune system dysregulation. Among environmental factors, viruses are most often connected with the etiology of MS.Human Endogenous Retroviruses (HERVs) constitute 5-8% of human genomic DNA and have been detected as transcripts and proteins in the central nervous system (CNS) and peripheral blood, frequently in the context of neuroinflammation. The HERV-Fc1, which belongs to the HERV-H/F family, has received our attention largely because of the genetic association with MS.The authors studied the expression of a capsid (Gag) protein of HERV-H/F origin by flow cytometry in PBMCs from healthy controls and from MS patients with non-active or active disease. There was a significant increase in HERV-H/F Gag expression in CD4+ (P

U2 - 10.1128/JVI.06723-11

DO - 10.1128/JVI.06723-11

M3 - Journal article

C2 - 22278236

VL - 86

SP - 3713

EP - 3722

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

ER -