Torben Sigsgaard

Specific inhalation challenge in the diagnosis of occupational asthma: consensus statement

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Olivier Vandenplas
  • ,
  • Hille Suojalehto, Ukendt
  • Tor B Aasen
  • ,
  • Xaver Baur
  • ,
  • P Sherwood Burge
  • ,
  • Frederic de Blay, Ukendt
  • David Fishwick, Ukendt
  • Jennifer Hoyle, Ukendt
  • Piero Maestrelli
  • ,
  • Xavier Muñoz
  • ,
  • Gianna Moscato, Ukendt
  • Joaquin Sastre, Ukendt
  • Torben Sigsgaard
  • Katri Suuronen, Ukendt
  • Jolanta Walusiak-Skorupa, Ukendt
  • Paul Cullinan
  • ,
  • ERS Task Force on Specific Inhalation Challenges with Occupational Agents

This consensus statement provides practical recommendations for specific inhalation challenge (SIC) in the diagnosis of occupational asthma. They are derived from a systematic literature search, a census of active European centres, a Delphi conference and expert consensus. This article details each step of a SIC, including safety requirements, techniques for delivering agents, and methods for assessing and interpreting bronchial responses. The limitations of the procedure are also discussed. Testing should only be carried out in hospitals where physicians and healthcare professionals have appropriate expertise. Tests should always include a control challenge, a gradual increase of exposure to the suspected agent, and close monitoring of the patient during the challenge and for at least 6 h afterwards. In expert centres, excessive reactions provoked by SIC are rare. A positive response is defined by a fall in forced expiratory volume in 1 s ≥ 15% from baseline. Equivocal reactions can sometimes be clarified by finding changes in nonspecific bronchial responsiveness, sputum eosinophils or exhaled nitric oxide. The sensitivity and specificity of SIC are high but not easily quantified, as the method is usually used as the reference standard for the diagnosis of occupational asthma.

TidsskriftEuropean Respiratory Journal
Sider (fra-til)1573-87
Antal sider15
StatusUdgivet - jun. 2014

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