Torben Sigsgaard

Occupational exposures and incidence of chronic bronchitis and related symptoms over two decades: the European Community Respiratory Health Survey

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Theodore Lytras, ISGlobal, ISGlobal, Universitat Pompeu Fabra, Barcelona
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  • Manolis Kogevinas, ISGlobal, ISGlobal, Universitat Pompeu Fabra, CIBER Epidemiología y Salud Pública (CIBERESP), Spain., Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Catalonia, Spain.
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  • Hans Kromhout, University of Utrecht
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  • Anne-Elie Carsin, ISGlobal, ISGlobal, Universitat Pompeu Fabra, CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
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  • Josep Maria Antó, ISGlobal, ISGlobal, Universitat Pompeu Fabra, CIBER Epidemiología y Salud Pública (CIBERESP), Spain., Hospital del Mar Institute of Medical Research (IMIM), Barcelona, Catalonia, Spain.
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  • Hayat Bentouhami, University of Antwerp, Antwerp
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  • Joost Weyler, University of Antwerp, Antwerp
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  • Joachim Heinrich, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Ludwig Maximilians University, Comprehensive Pneumology Centre Munich, German Centre for Lung Research, Munich, Germany.
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  • Dennis Nowak, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Ludwig Maximilians University, Comprehensive Pneumology Centre Munich, German Centre for Lung Research, Munich, Germany.
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  • Isabel Urrutia, Pulmonology Department, Galdakao-Usansolo Hospital, Biscay, Spain.
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  • Jesús Martínez-Moratalla, 13 Servicio de Numología, Complejo Hospitalario Universitario de Albacete, Albacete, Spain., University of Castilla-La Mancha
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  • José Antonio Gullón, Respiratory Department, Hospital Universitario San Agustín, Aviles, Spain.
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  • Antonio Pereira Vega, Pulmonology and Allergy Clinical Unit, University Hospital Juan Ramón Jiménez, Huelva, Spain.
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  • Chantal Raherison Semjen, Université de Bordeaux, Inserm, Bordeaux Population Health Research Center, team EPICENE, UMR 1219, Bordeaux, France.
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  • Isabelle Pin, Universite Grenoble Alpes, France., Department of Pédiatrie, CHU de Grenoble Alpes, Grenoble, France., INSERM
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  • Pascal Demoly, Sorbonne Universités, UPMC Univ Paris 06, UMR 7095, Institut d’Astrophysique de Paris, 98 bis boulevard Arago, F-75014, Paris, France, Department of Pneumology, University Hospital of Montpellier, Montpellier, France.
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  • Bénédicte Leynaert, Inserm UMR 1152-Equipe Epidémiologie, Université Paris Diderot, Paris, France.
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  • Simona Villani, Section of Epidemiology and Medical Statistics, Department of Health Sciences, University of Pavia, Pavia, Italy.
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  • Thorarinn Gíslason, The Icelandic Cancer Registry, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
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  • Øistein Svanes, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway., University of Bergen
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  • Mathias Holm, Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; Section of Occupational and Environmental Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
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  • Bertil Forsberg, Department of Public Health and Clinical Medicine/Occupational & Environmental Medicine, Umeå University, Umeå, Sweden.
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  • Dan Norbäck, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden; Section of Clinical Chemistry, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
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  • Amar J Mehta, Research and Evaluation Office, Boston Public Health Commission, Boston, Massachusetts, USA.
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  • Nicole Probst-Hensch, Centre for International Health, University of Bergen, Norway, Department of Epidemiology and Public Health, Gender & Health, Swiss Tropical and Public Health Institute, Basel University, Switzerland.
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  • Geza Benke, Monash Centre for Occupation and Environmental Health, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
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  • Rain Jogi, Tartu University Hospital, Lung Clinic, Estonia, Europe.
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  • Kjell Torén, Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; Section of Occupational and Environmental Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • ,
  • Torben Sigsgaard
  • Vivi Schlünssen
  • Mario Olivieri, Unit of Occupational Medicine, University Hospital of Verona, Verona, Italy.
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  • Paul D Blanc, University of California San Francisco, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.
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  • John Watkins, Public Health Wales, Cardiff, Wales, UK., Cardiff University
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  • Roberto Bono, Department of Public Health and Pediatrics, University of Turin, Torino, Italy.
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  • A Sonia Buist, Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA.
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  • Roel Vermeulen, Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.
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  • Deborah Jarvis, MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom., Cardiff University, Public Health Wales, Cardiff, Wales, UK., University of Turin
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  • Jan-Paul Zock, CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., ISGlobal, ISGlobal, Universitat Pompeu Fabra

OBJECTIVES: Chronic bronchitis (CB) is an important chronic obstructive pulmonary disease (COPD)-related phenotype, with distinct clinical features and prognostic implications. Occupational exposures have been previously associated with increased risk of CB but few studies have examined this association prospectively using objective exposure assessment. We examined the effect of occupational exposures on CB incidence in the European Community Respiratory Health Survey.

METHODS: Population samples aged 20-44 were randomly selected in 1991-1993, and followed up twice over 20 years. Participants without chronic cough or phlegm at baseline were analysed. Coded job histories during follow-up were linked to the ALOHA Job Exposure Matrix, generating occupational exposure estimates to 12 categories of chemical agents. Their association with CB incidence over both follow-ups was examined with Poisson models using generalised estimating equations.

RESULTS: 8794 participants fulfilled the inclusion criteria, contributing 13 185 observations. Only participants exposed to metals had a higher incidence of CB (relative risk (RR) 1.70, 95% CI 1.16 to 2.50) compared with non-exposed to metals. Mineral dust exposure increased the incidence of chronic phlegm (RR 1.72, 95% CI 1.43 to 2.06). Incidence of chronic phlegm was increased in men exposed to gases/fumes and to solvents and in women exposed to pesticides.

CONCLUSIONS: Occupational exposures are associated with chronic phlegm and CB, and the evidence is strongest for metals and mineral dust exposure. The observed differences between men and women warrant further investigation.

OriginalsprogEngelsk
TidsskriftOccupational and Environmental Medicine
Vol/bind76
Nummer4
Sider (fra-til)222-229
Antal sider8
ISSN1351-0711
DOI
StatusUdgivet - apr. 2019

Bibliografisk note

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

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