Torben Sigsgaard

Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Theodore Lytras, Departament de Ciències Experimentals i de la Salut (UPF), Universitat Pompeu Fabra, Barcelona, Spain., Spanien
  • Manolis Kogevinas, Health Services Research Unit, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain., Spanien
  • Hans Kromhout, Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands., Holland
  • Anne-Elie Carsin, Departament de Ciències Experimentals i de la Salut (UPF), Universitat Pompeu Fabra, Barcelona, Spain., Spanien
  • Josep M Antó, Health Services Research Unit, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain., Spanien
  • Hayat Bentouhami, Department of Epidemiology and Social Medicine (ESOC), Faculty of Medicine and Health Sciences, StatUA Statistics Centre, University of Antwerp, Antwerp, Belgium., Belgien
  • Joost Weyler, Department of Epidemiology and Social Medicine (ESOC), Faculty of Medicine and Health Sciences, StatUA Statistics Centre, University of Antwerp, Antwerp, Belgium., Belgien
  • Joachim Heinrich, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Ludwig Maximilians University, Comprehensive Pneumology Centre Munich, German Centre for Lung Research, Munich, Germany., Tyskland
  • Dennis Nowak, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Ludwig Maximilians University, Comprehensive Pneumology Centre Munich, German Centre for Lung Research, Munich, Germany., Tyskland
  • Isabel Urrutia, Pulmonology Department, Galdakao Hospital, Bizkaia, Spain., Spanien
  • Jesús Martinez-Moratalla, Facultad de Medicina Albacete, Universidad de Castilla-La Mancha, Ciudad Real, Spain., Spanien
  • José Antonio Gullón, Respiratory Department, Hospital Universitario San Agustín, Aviles, Spain., Spanien
  • Antonio Pereira-Vega, Respiratory and Allergy Clinical Unit, Universitary Hospitalary Complex, Huelva, Spain., Spanien
  • Chantal Raherison-Semjen, Université de Bordeaux, Inserm, Bordeaux Population Health Research Center, team EPICENE, UMR 1219, Bordeaux, France., Frankrig
  • Isabelle Pin, Universite Grenoble Alpes, France., Frankrig
  • Pascal Demoly, Sorbonne Universités, UPMC Univ Paris 06, UMR 7095, Institut d’Astrophysique de Paris, 98 bis boulevard Arago, F-75014, Paris, France, Frankrig
  • Bénédicte Leynaert, Inserm UMR 1152-Equipe Epidémiologie, Université Paris Diderot, Paris, France., Frankrig
  • Simona Villani, Department of Health Sciences, Experimental and Forensic Medicine - Unit of Biostatistics and Clinical Epidemiology, University of Pavia, Pavia, Italy., Italien
  • Thorarinn Gislason, Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Island
  • Cecilie Svanes, Centre for International Health, University of Bergen, Norway, Centre for International Health, University of Bergen, Norway., Norge
  • Mathias Holm, Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; Section of Occupational and Environmental Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Sverige
  • Bertil Forsberg, Department of Public Health and Clinical Medicine/Occupational & Environmental Medicine, Umeå University, Umeå, Sweden., Sverige
  • Dan Norbäck, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden; Section of Clinical Chemistry, Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Sverige
  • Amar J Mehta, Research and Evaluation Office, Boston Public Health Commission, Boston, Massachusetts, USA., USA
  • Nicole Probst-Hensch, University of Basel, Basel, Switzerland, Schweiz
  • Geza Benke, Monash Centre for Occupation and Environmental Health, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia., Australien
  • Rain Jogi, Lung Clinic, Tartu University Hospital, Tartu, Estonia., Estland
  • Kjell Torén, Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; Section of Occupational and Environmental Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Sverige
  • Torben Sigsgaard
  • Vivi Schlünssen
  • Mario Olivieri, Unit of Occupational Medicine, University Hospital of Verona, Verona, Italy., Italien
  • Paul D Blanc, University of California San Francisco, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA., USA
  • Roel Vermeulen, Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands., Holland
  • Judith Garcia-Aymerich, Health Services Research Unit, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain., Spanien
  • Deborah Jarvis, MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom., Storbritannien
  • Jan-Paul Zock, CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain., Spanien

BACKGROUND: Occupational exposures have been associated with an increased risk of COPD. However, few studies have related objectively assessed occupational exposures to prospectively assessed incidence of COPD, using postbronchodilator lung function tests. Our objective was to examine the effect of occupational exposures on COPD incidence in the European Community Respiratory Health Survey.

METHODS: General population samples aged 20-44 were randomly selected in 1991-1993 and followed up 20 years later (2010-2012). Spirometry was performed at baseline and at follow-up, with incident COPD defined using a lower limit of normal criterion for postbronchodilator FEV1/FVC. Only participants without COPD and without current asthma at baseline were included. Coded job histories during follow-up were linked to a Job-Exposure Matrix, generating occupational exposure estimates to 12 categories of agents. Their association with COPD incidence was examined in log-binomial models fitted in a Bayesian framework.

FINDINGS: 3343 participants fulfilled the inclusion criteria; 89 of them had COPD at follow-up (1.4 cases/1000 person-years). Participants exposed to biological dust had a higher incidence of COPD compared with those unexposed (relative risk (RR) 1.6, 95% CI 1.1 to 2.3), as did those exposed to gases and fumes (RR 1.5, 95% CI 1.0 to 2.2) and pesticides (RR 2.2, 95% CI 1.1 to 3.8). The combined population attributable fraction for these exposures was 21.0%.

INTERPRETATION: These results substantially strengthen the evidence base for occupational exposures as an important risk factor for COPD.

OriginalsprogEngelsk
TidsskriftThorax
Vol/bind73
Nummer11
Sider (fra-til)1008-1015
Antal sider8
ISSN0040-6376
DOI
StatusUdgivet - 1 nov. 2018

Bibliografisk note

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