Torben Sigsgaard

IgE sensitization to bacterial and fungal biopesticides in a cohort of Danish greenhouse workers: the BIOGART study

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IgE sensitization to bacterial and fungal biopesticides in a cohort of Danish greenhouse workers: the BIOGART study. / Doekes, G.; Larsen, Preben; Sigsgaard, Torben; Bælum, Jesper.

I: American Journal of Industrial Medicine, Bind 46, Nr. 4, 10.2004, s. 404-407.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Doekes, G, Larsen, P, Sigsgaard, T & Bælum, J 2004, 'IgE sensitization to bacterial and fungal biopesticides in a cohort of Danish greenhouse workers: the BIOGART study', American Journal of Industrial Medicine, bind 46, nr. 4, s. 404-407. https://doi.org/10.1002/ajim.20086

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Author

Doekes, G. ; Larsen, Preben ; Sigsgaard, Torben ; Bælum, Jesper. / IgE sensitization to bacterial and fungal biopesticides in a cohort of Danish greenhouse workers: the BIOGART study. I: American Journal of Industrial Medicine. 2004 ; Bind 46, Nr. 4. s. 404-407.

Bibtex

@article{eb5bfec0983e11dabee902004c4f4f50,
title = "IgE sensitization to bacterial and fungal biopesticides in a cohort of Danish greenhouse workers:: the BIOGART study",
abstract = "BACKGROUND: The use of biopesticides in agriculture may implicate new risks of work-related allergic reactions. METHODS: Sera were tested from the BIOGART project, a longitudinal respiratory health study among >300 Danish greenhouse workers. IgE was measured by enzyme immunoassay (EIA) with extracts of biopesticide products containing Bacillus thuringiensis (BT) or Verticillium lecanii (Vert). RESULTS: Many sera had detectable IgE to BT (23-29{\%}) or Vert (9-21{\%}). IgE titers from the 2- and 3-year follow-up (n=230) were highly correlated, with discordant results in <15{\%}. IgE titers to different BT, or to different Verticillium products were also significantly correlated (both r >0.70), whereas IgE anti-BT and anti-Verticillium showed no correlation at all. CONCLUSIONS: Exposure to these microbial biopesticides may confer a risk of IgE-mediated sensitization. In future research there is a need to identify allergenic components in the preparations, perform studies on non-exposed controls and analyze the relation between sensitization and health parameters.",
author = "G. Doekes and Preben Larsen and Torben Sigsgaard and Jesper B{\ae}lum",
year = "2004",
month = "10",
doi = "10.1002/ajim.20086",
language = "English",
volume = "46",
pages = "404--407",
journal = "American Journal of Industrial Medicine",
issn = "0271-3586",
publisher = "JohnWiley & Sons, Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - IgE sensitization to bacterial and fungal biopesticides in a cohort of Danish greenhouse workers:

T2 - the BIOGART study

AU - Doekes, G.

AU - Larsen, Preben

AU - Sigsgaard, Torben

AU - Bælum, Jesper

PY - 2004/10

Y1 - 2004/10

N2 - BACKGROUND: The use of biopesticides in agriculture may implicate new risks of work-related allergic reactions. METHODS: Sera were tested from the BIOGART project, a longitudinal respiratory health study among >300 Danish greenhouse workers. IgE was measured by enzyme immunoassay (EIA) with extracts of biopesticide products containing Bacillus thuringiensis (BT) or Verticillium lecanii (Vert). RESULTS: Many sera had detectable IgE to BT (23-29%) or Vert (9-21%). IgE titers from the 2- and 3-year follow-up (n=230) were highly correlated, with discordant results in <15%. IgE titers to different BT, or to different Verticillium products were also significantly correlated (both r >0.70), whereas IgE anti-BT and anti-Verticillium showed no correlation at all. CONCLUSIONS: Exposure to these microbial biopesticides may confer a risk of IgE-mediated sensitization. In future research there is a need to identify allergenic components in the preparations, perform studies on non-exposed controls and analyze the relation between sensitization and health parameters.

AB - BACKGROUND: The use of biopesticides in agriculture may implicate new risks of work-related allergic reactions. METHODS: Sera were tested from the BIOGART project, a longitudinal respiratory health study among >300 Danish greenhouse workers. IgE was measured by enzyme immunoassay (EIA) with extracts of biopesticide products containing Bacillus thuringiensis (BT) or Verticillium lecanii (Vert). RESULTS: Many sera had detectable IgE to BT (23-29%) or Vert (9-21%). IgE titers from the 2- and 3-year follow-up (n=230) were highly correlated, with discordant results in <15%. IgE titers to different BT, or to different Verticillium products were also significantly correlated (both r >0.70), whereas IgE anti-BT and anti-Verticillium showed no correlation at all. CONCLUSIONS: Exposure to these microbial biopesticides may confer a risk of IgE-mediated sensitization. In future research there is a need to identify allergenic components in the preparations, perform studies on non-exposed controls and analyze the relation between sensitization and health parameters.

U2 - 10.1002/ajim.20086

DO - 10.1002/ajim.20086

M3 - Journal article

VL - 46

SP - 404

EP - 407

JO - American Journal of Industrial Medicine

JF - American Journal of Industrial Medicine

SN - 0271-3586

IS - 4

ER -