Torben Sigsgaard

Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role?

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Lidwien A M Smit
  • ,
  • David P Strachan
  • ,
  • Roel Vermeulen
  • ,
  • Paul I W de Bakker
  • ,
  • Florence Demenais
  • ,
  • Orianne Dumas, Ukendt
  • Anne-Elie Carsin
  • ,
  • Paul Cullinan, Ukendt
  • Ivan Curjuric
  • ,
  • Rebecca E Ghosh, Ukendt
  • Dick Heederik
  • ,
  • Medea Imboden
  • ,
  • Deborah Jarvis
  • ,
  • Mark Lathrop
  • ,
  • Nicole Le Moual
  • ,
  • Amar Mehta
  • ,
  • David Miedinger, Ukendt
  • Torben Sigsgaard
  • Valérie Siroux
  • ,
  • David Vernez, Ukendt
  • Jan Paul Zock
  • ,
  • Francine Kauffmann, Ukendt
  • Nicole Probst-Hensch
  • ,
  • Manolis Kogevinas
  • ,
  • Emmanuelle Bouzigon

Recently, a locus centred on rs9273349 in the HLA-DQ region emerged from genome-wide association studies of adult-onset asthma. We aimed to further investigate the role of human leukocyte antigen (HLA) class II in adult-onset asthma and a possible interaction with occupational exposures. We imputed classical HLA-II alleles from 7579 single-nucleotide polymorphisms in 6025 subjects (1202 with adult-onset asthma) from European cohorts: ECRHS, SAPALDIA, EGEA and B58C, and from surveys of bakers and agricultural workers. Based on an asthma-specific job-exposure matrix, 2629 subjects had ever been exposed to high molecular weight (HMW) allergens. We explored associations between 23 common HLA-II alleles and adult-onset asthma, and tested for gene-environment interaction with occupational exposure to HMW allergens. Interaction was also tested for rs9273349. Marginal associations of classical HLA-II alleles and adult-onset asthma were not statistically significant. Interaction was detected between the DPB1*03:01 allele and exposure to HMW allergens (p = 0.009), in particular to latex (p = 0.01). In the unexposed group, the DPB1*03:01 allele was associated with adult-onset asthma (OR 0.67, 95%CI 0.53-0.86). HMW allergen exposures did not modify the association of rs9273349 with adult-onset asthma. Common classical HLA-II alleles were not marginally associated with adult-onset asthma. The association of latex exposure and adult-onset asthma may be modified by DPB1*03:01.

OriginalsprogEngelsk
TidsskriftEuropean Respiratory Journal
Vol/bind44
Nummer5
Sider (fra-til)1234-42
Antal sider9
ISSN0903-1936
DOI
StatusUdgivet - nov. 2014

Se relationer på Aarhus Universitet Citationsformater

ID: 84326547