Torben Sigsgaard

Genetiske og miljømæssige faktorers betydning for asthma. Et populations-baseret studium af 11.688 danske tvillingepar

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  • Lars Rauff Skadhauge, Arbejdsmedicinsk Afdeling, Danmark
  • Kaare Christensen, Danmark
  • Kirsten Ohm Kyvik, SUND ph.d. skole, Danmark
  • Torben Sigsgaard
The aim of this study was to estimate the relative influence of genetic and environmental factors on the aetiology of asthma. The classic twin study design was used to analyse data on self-reported asthma obtained by a questionnaire mailed to 34,076 individuals, aged 12-41 yrs and originating from the Danish Twin Register. The cumulative incidence proportion was 6.2% in the pooled sample. No overall sex or zygosity difference was observed. Substantially higher concordance rate, odds ratio and correlation for asthma were estimated in monozygotic than dizygotic twin pairs. Using biometric modelling, a model including additive genetic and non-shared environmental effects provided the best fit to the data. According to this model, 73% of the variation in liability to asthma was explained by genetic effects. The results emphasize a major genetic component in the aetiology of asthma.
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind162
Nummer26
Sider (fra-til)3726-9
Antal sider4
ISSN0041-5782
StatusUdgivet - 2000

    Forskningsområder

  • Adult, Asthma, Child, Cohort Studies, Denmark, Diseases in Twins, Environmental Exposure, Female, Genetic Predisposition to Disease, Humans, Male, Registries, Twins, Dizygotic, Twins, Monozygotic

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