Torben Sigsgaard

Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment: DiMoPEx-project is designed to determine the impacts of environmental exposure on human health

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

DOI

  • Lygia Therese Budnik, 1Division of Translational Toxicology and Immunology, Institute for Occupational and Maritime Medicine (ZfAM), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
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  • Balazs Adam, 2Faculty of Public Health, Department of Preventive Medicine, University of Debrecen, Debrecen, Hungary.
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  • Maria Albin, 4Karolinska Institutet, Institute of Environmental Medicine (IMM), Stockholm, Sweden.
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  • Barbara Banelli, 5Tumor Epigenetics Unit, Ospedale Policlinico San Martino, National Cancer Institute, IRCCS and University of Genoa, DISSAL, Genoa, Italy.
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  • Xaver Baur, European Society for Environmental and Occupational Medicine, Berlin, Germany.
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  • Fiorella Belpoggi, Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bentivoglio, Bologna, Italy.
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  • Claudia Bolognesi, 8San Martino-IST Environmental Carcinogenesis Unit, IRCCS, Ospedale Policlinico San Martino, National Cancer Institute, Genoa, Italy.
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  • Karin Broberg, 4Karolinska Institutet, Institute of Environmental Medicine (IMM), Stockholm, Sweden.
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  • Per Gustavsson, 4Karolinska Institutet, Institute of Environmental Medicine (IMM), Stockholm, Sweden.
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  • Thomas Göen, 9Social and Environmental Medicine, Institute and Outpatient Clinic of Occupational, Friedrich-Alexander-University Erlangen-Nurnberg, Erlangen, Germany.
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  • Axel Fischer, 10Institute of Occupational Medicine, Charité Universitäts Medizin, Berlin, Germany.
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  • Dorota Jarosinska, WHO European Centre for Environment and Health, Bonn, Germany,
  • Fabiana Manservisi, Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bentivoglio, Bologna, Italy.
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  • Richard O'Kennedy, 12Biomedical Diagnostics Institute, Dublin City University, Dublin, Ireland.
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  • Johan Øvrevik, 13Norwegian Institute of Public Health, Oslo, Norway.
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  • Elizabet Paunovic, WHO European Centre for Environment and Health, Bonn, Germany,
  • Beate Ritz, 14Center for Occupational and Environmental Health, Fielding School of Public Health (FSPH), University of California Los Angeles (UCLA), Los Angeles, USA.
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  • Paul T J Scheepers, 15Radboud Institute for Health Sciences, Radboudumc (Radboud university medical center), Nijmegen, the Netherlands.
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  • Vivi Schlünssen
  • Heidi Schwarzenbach, 18Department of Tumor Biology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
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  • Per E Schwarze, 13Norwegian Institute of Public Health, Oslo, Norway.
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  • Orla Sheils, Department of Histopathology, Central Pathology Laboratory, St James's Hospital, Trinity translational Medicine Institute, Dublin, Ireland.
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  • Torben Sigsgaard
  • Karel Van Damme, 20Center for Human Genetics, University of Leuven, Leuven, Belgium.
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  • Ludwine Casteleyn, 20Center for Human Genetics, University of Leuven, Leuven, Belgium.

The WHO has ranked environmental hazardous exposures in the living and working environment among the top risk factors for chronic disease mortality. Worldwide, about 40 million people die each year from noncommunicable diseases (NCDs) including cancer, diabetes, and chronic cardiovascular, neurological and lung diseases. The exposure to ambient pollution in the living and working environment is exacerbated by individual susceptibilities and lifestyle-driven factors to produce complex and complicated NCD etiologies. Research addressing the links between environmental exposure and disease prevalence is key for prevention of the pandemic increase in NCD morbidity and mortality. However, the long latency, the chronic course of some diseases and the necessity to address cumulative exposures over very long periods does mean that it is often difficult to identify causal environmental exposures. EU-funded COST Action DiMoPEx is developing new concepts for a better understanding of health-environment (including gene-environment) interactions in the etiology of NCDs. The overarching idea is to teach and train scientists and physicians to learn how to include efficient and valid exposure assessments in their research and in their clinical practice in current and future cooperative projects. DiMoPEx partners have identified some of the emerging research needs, which include the lack of evidence-based exposure data and the need for human-equivalent animal models mirroring human lifespan and low-dose cumulative exposures. Utilizing an interdisciplinary approach incorporating seven working groups, DiMoPEx will focus on aspects of air pollution with particulate matter including dust and fibers and on exposure to low doses of solvents and sensitizing agents. Biomarkers of early exposure and their associated effects as indicators of disease-derived information will be tested and standardized within individual projects. Risks arising from some NCDs, like pneumoconioses, cancers and allergies, are predictable and preventable. Consequently, preventative action could lead to decreasing disease morbidity and mortality for many of the NCDs that are of major public concern. DiMoPEx plans to catalyze and stimulate interaction of scientists with policy-makers in attacking these exposure-related diseases.

OriginalsprogEngelsk
TidsskriftJournal of Occupational Medicine and Toxicology (London)
Vol/bind13
Nummer6
Antal sider22
ISSN1745-6673
DOI
StatusUdgivet - 2018

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