Torben Sigsgaard

Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III

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DOI

  • Elisabet Nerpin, Uppsala universitet, Dalarna University
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  • Mario Olivieri, University of Verona
  • ,
  • Thorainn Gislason, Landspitali University Hospital, Reykjavik, University of Iceland
  • ,
  • Anna C. Olin, Göteborgs Universitet
  • ,
  • Rune Nielsen, Department of Clinical Science, Universitetet i Bergen, Department of Occupational Medicine, Haukeland University Hospital, NO-5021 Bergen, Norway. tor.aasen@helse-bergen.no.
  • ,
  • Ane Johannessen, Universitetet i Bergen, Department of Occupational Medicine, Haukeland University Hospital, NO-5021 Bergen, Norway. tor.aasen@helse-bergen.no.
  • ,
  • Diogenes S. Ferreira, Monash University, Universidade Federal do Paraná
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  • Alessandro Marcon, University of Verona
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  • Lucia Cazzoletti, University of Verona
  • ,
  • Simone Accordini, University of Verona
  • ,
  • Isabelle Pin, University Hospital of Grenoble Alpes (CHU-GA), Inserm, Univ. Grenoble Alpes
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  • Angelo Corsico, IRCCS Policlinico S. Matteo Foundation, Università Degli Studi di Pavia
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  • Pascal Demoly, univ Montpellier, Inserm
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  • Joost Weyler, Dept. of Biology, Universiteit Antwerpen
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  • Dennis Nowak, Klinikum Grosshaden, German Center for Lung Research (DZL)
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  • Rain Jõgi, Tartu University Hospital
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  • Bertil Forsberg, Clinical Sciences, Umea universitet, Klinisk vetenskap.
  • ,
  • Jan P. Zock, Barcelona Institute for Global Health, Universitat Pompeu Fabra, Barcelona, Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública-CIBERESP)
  • ,
  • Torben Sigsgaard
  • Joachim Heinric, Klinikum Grosshaden, Helmholtz Zentrum München - German Research Center for Environmental Health, University Melbourne
  • ,
  • Roberto Bono, Università degli Studi di Torino
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  • Bénédicte Leynaert, Inserm, Université Paris—Denis Diderot
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  • Deborah Jarvis, National Heart and Lung Institute
  • ,
  • Christer Janson, Uppsala universitet
  • ,
  • Anderi Malinovschi, Uppsala universitet
  • ,
  • on behalf of the European Community Respiratory Health Survey (ECRHS) study group

Introduction: The fractional exhaled nitric oxide (FENO) is a marker for type 2 inflammation used in diagnostics and management of asthma. In order to use FENO as a reliable biomarker, it is important to investigate factors that influence FENO in healthy individuals. Men have higher levels of FENO than women, but it is unclear whether determinants of FENO differ by sex. Objective: To identify determinants of FENO in men and women without lung diseases. Method: Fractional exhaled nitric oxide was validly measured in 3881 healthy subjects that had answered the main questionnaire of the European Community Respiratory Health Survey III without airways or lung disease. Results: Exhaled NO levels were 21.3% higher in men compared with women P < 0.001. Being in the upper age quartile (60.3-67.6 years), men had 19.2 ppb (95% CI: 18.3, 20.2) higher FENO than subjects in the lowest age quartile (39.7-48.3 years) P = 0.02. Women in the two highest age quartiles (54.6-60.2 and 60.3-67.6 years) had 15.4 ppb (14.7, 16.2), P = 0.03 and 16.4 ppb (15.6, 17.1), P = <0.001 higher FENO, compared with the lowest age quartile. Height was related to 8% higher FENO level in men (P < 0.001) and 5% higher FENO levels in women (P = 0.008). Men who smoked had 37% lower FENO levels and women had 30% lower levels compared with never-smokers (P < 0.001 for both). Men and women sensitized to both grass and perennial allergens had higher FENO levels compared with non-sensitized subjects 26% and 29%, P < 0.001 for both. Conclusion and Clinical Relevance: Fractional exhaled nitric oxide levels were higher in men than women. Similar effects of current smoking, height, and IgE sensitization were found in both sexes. FENO started increasing at lower age in women than in men, suggesting that interpretation of FENO levels in adults aged over 50 years should take into account age and sex.

OriginalsprogEngelsk
TidsskriftClinical and Experimental Allergy
Vol/bind49
Nummer7
Sider (fra-til)969-979
Antal sider11
ISSN0954-7894
DOI
StatusUdgivet - 2019

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