Torben Sigsgaard

Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review


  • R J Bertelsen, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway., Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Institute of Clinical Medicine, University of Bergen, Bergen, Norway., Norge
  • M Rava, Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, CNIO (Spanish National Cancer Research Center), Madrid, Spain., Spanien
  • A E Carsin, Navarre Public Health Institute (ISPN), Pamplona, Spain CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain., Spanien
  • S Accordini, Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy., Italien
  • B Benediktsdóttir, Department of Allergy, Respiratory Medicine and Sleep, Landspitali University Hospital, Reykjavik, Iceland, University of Iceland, Medical Faculty., Island
  • J Dratva, Centre for International Health, University of Bergen, Norway, Department of Epidemiology and Public Health, Gender & Health, Swiss Tropical and Public Health Institute, Basel University, Switzerland., Schweiz
  • K A Franklin, Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden., Sverige
  • J Heinrich, Institute and Outpatient Clinic for Occupational, Social, and Environmental Medicine, Ludwig Maximilians University Munich, Munchen, Germany., Tyskland
  • M Holm, Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden; Section of Occupational and Environmental Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Sverige
  • C Janson, Department of Medical Sciences, Uppsala University, Sweden., Sverige
  • A Johannessen, Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway., Norge
  • D L Jarvis, Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, UK., Storbritannien
  • R Jogi, Lung Clinic, Tartu University Hospital, Tartu, Estonia., Estland
  • B Leynaert, UMR 1152, University Paris Diderot Paris 7, Paris, France., Frankrig
  • D Norback, Department of Medical Sciences, Uppsala University, Sweden., Sverige
  • E R Omenaas, Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway., Norge
  • C Raherison, INSERM U897 Bordeaux University, Bordeaux Cedex, France., Frankrig
  • J L Sánchez-Ramos, Department of Nursing, University of Huelva, Huelva, Spain., Spanien
  • V Schlünssen
  • T Sigsgaard
  • S C Dharmage, Allergy and Lung Health Unit, Melbourne School of Population Health, The University of Melbourne, Melbourne, Vic., Australia., Australien
  • C Svanes, Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. Electronic address:, Norge

BACKGROUND: Mice models suggest epigenetic inheritance induced by parental allergic disease activity. However, we know little of how parental disease activity before conception influences offspring's asthma and allergy in humans.

OBJECTIVE: We aimed to assess the associations of parental asthma severity, bronchial hyperresponsiveness (BHR), and total and specific IgEs, measured before conception vs. after birth, with offspring asthma and hayfever.

METHODS: The study included 4293 participants (mean age 34, 47% men) from the European Community Respiratory Health Survey (ECRHS) with information on asthma symptom severity, BHR, total and specific IgEs from 1991 to 1993, and data on 9100 offspring born 1972-2012. Adjusted relative risk ratios (aRRR) for associations of parental clinical outcome with offspring allergic disease were estimated with multinomial logistic regressions.

RESULTS: Offspring asthma with hayfever was more strongly associated with parental BHR and specific IgE measured before conception than after birth [BHR: aRRR = 2.96 (95% CI: 1.92, 4.57) and 1.40 (1.03, 1.91), respectively; specific IgEs: 3.08 (2.13, 4.45) and 1.83 (1.45, 2.31), respectively]. This was confirmed in a sensitivity analysis of a subgroup of offspring aged 11-22 years with information on parental disease activity both before and after birth.

CONCLUSION & CLINICAL RELEVANCE: Parental BHR and specific IgE were associated with offspring asthma and hayfever, with the strongest associations observed with clinical assessment before conception as compared to after birth of the child. If the hypothesis is confirmed in other studies, parental disease activity assessed before conception may prove useful for identifying children at risk for developing asthma with hayfever.

TidsskriftClinical and Experimental Allergy
Sider (fra-til)627-638
Antal sider12
StatusUdgivet - maj 2017

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