Torben Sigsgaard

A nationwide follow-up study of occupational organic dust exposure and risk of chronic obstructive pulmonary disease (COPD)

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A nationwide follow-up study of occupational organic dust exposure and risk of chronic obstructive pulmonary disease (COPD). / Vested, Anne; Basinas, Ioannis; Burdorf, Alex; Elholm, Grethe; Heederik, Dick J J; Jacobsen, Gitte H; Kolstad, Henrik A; Kromhout, Hans; Omland, Øyvind; Sigsgaard, Torben; Thulstrup, Ane M; Toft, Gunnar; Vestergaard, Jesper M; Wouters, Inge M; Schlünssen, Vivi.

I: Occupational and Environmental Medicine, Bind 76, Nr. 2, 15.01.2019, s. 105-113.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Vested A, Basinas I, Burdorf A, Elholm G, Heederik DJJ, Jacobsen GH o.a. A nationwide follow-up study of occupational organic dust exposure and risk of chronic obstructive pulmonary disease (COPD). Occupational and Environmental Medicine. 2019 jan 15;76(2):105-113. https://doi.org/10.1136/oemed-2018-105323

Author

Vested, Anne ; Basinas, Ioannis ; Burdorf, Alex ; Elholm, Grethe ; Heederik, Dick J J ; Jacobsen, Gitte H ; Kolstad, Henrik A ; Kromhout, Hans ; Omland, Øyvind ; Sigsgaard, Torben ; Thulstrup, Ane M ; Toft, Gunnar ; Vestergaard, Jesper M ; Wouters, Inge M ; Schlünssen, Vivi. / A nationwide follow-up study of occupational organic dust exposure and risk of chronic obstructive pulmonary disease (COPD). I: Occupational and Environmental Medicine. 2019 ; Bind 76, Nr. 2. s. 105-113.

Bibtex

@article{b36f7972ed54446fb1849b40dc0afcb7,
title = "A nationwide follow-up study of occupational organic dust exposure and risk of chronic obstructive pulmonary disease (COPD)",
abstract = "OBJECTIVES: To study exposure-response relations between cumulative organic dust exposure and incident chronic obstructive pulmonary disease (COPD) among subjects employed in the Danish farming and wood industry.METHODS: We studied exposure-response relations between cumulative organic dust exposure and incident COPD (1997-2013) among individuals born during 1950-1977 in Denmark ever employed in the farming or wood industry (n=1 75 409). Industry-specific employment history (1964-2007), combined with time-dependent farming and wood industry-specific exposure matrices defined cumulative exposure. We used logistic regression analysis with discrete survival function adjusting for age, sex and calendar year. Adjustment for smoking status was explored in a subgroup of 4023 with smoking information available.RESULTS: Cumulative organic dust exposure was inversely associated with COPD (adjusted rate ratios (RRadj (95{\%} CIs) of 0.90 (0.82 to 0.99), 0.76 (0.69 to 0.84) and 0.52 (0.47 to 0.58) for intermediate-low, intermediate-high and high exposure quartiles, respectively, compared with the lowest exposure quartile). Lagging exposure 10 years was not consistently suggestive of an association between cumulative exposure and COPD; RRadj (95{\%} CI): 1.05 (0.94 to 1.16), 0.92 (0.83 to 1.02) and 0.63 (0.56 to 0.70). Additional stratification by duration of employment showed no clear association between organic dust exposure and COPD except for the longer exposed (15-40 years) where an inverse association was indicated. Subgroup analyses showed that smoking had no impact on exposure-response estimates.CONCLUSIONS: Our findings show no increased risk of COPD with increasing occupational exposure to organic dust in the farming or wood industry.Potential residual confounding by smoking can, however, not be ruled out.",
keywords = "chronic obstructive pulmonary disease (copd), epidemiology, occupational exposure, organic dusts",
author = "Anne Vested and Ioannis Basinas and Alex Burdorf and Grethe Elholm and Heederik, {Dick J J} and Jacobsen, {Gitte H} and Kolstad, {Henrik A} and Hans Kromhout and {\O}yvind Omland and Torben Sigsgaard and Thulstrup, {Ane M} and Gunnar Toft and Vestergaard, {Jesper M} and Wouters, {Inge M} and Vivi Schl{\"u}nssen",
note = "{\circledC} Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2019",
month = "1",
day = "15",
doi = "10.1136/oemed-2018-105323",
language = "English",
volume = "76",
pages = "105--113",
journal = "Occupational and Environmental Medicine",
issn = "1351-0711",
publisher = "B M J Group",
number = "2",

}

RIS

TY - JOUR

T1 - A nationwide follow-up study of occupational organic dust exposure and risk of chronic obstructive pulmonary disease (COPD)

AU - Vested, Anne

AU - Basinas, Ioannis

AU - Burdorf, Alex

AU - Elholm, Grethe

AU - Heederik, Dick J J

AU - Jacobsen, Gitte H

AU - Kolstad, Henrik A

AU - Kromhout, Hans

AU - Omland, Øyvind

AU - Sigsgaard, Torben

AU - Thulstrup, Ane M

AU - Toft, Gunnar

AU - Vestergaard, Jesper M

AU - Wouters, Inge M

AU - Schlünssen, Vivi

N1 - © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2019/1/15

Y1 - 2019/1/15

N2 - OBJECTIVES: To study exposure-response relations between cumulative organic dust exposure and incident chronic obstructive pulmonary disease (COPD) among subjects employed in the Danish farming and wood industry.METHODS: We studied exposure-response relations between cumulative organic dust exposure and incident COPD (1997-2013) among individuals born during 1950-1977 in Denmark ever employed in the farming or wood industry (n=1 75 409). Industry-specific employment history (1964-2007), combined with time-dependent farming and wood industry-specific exposure matrices defined cumulative exposure. We used logistic regression analysis with discrete survival function adjusting for age, sex and calendar year. Adjustment for smoking status was explored in a subgroup of 4023 with smoking information available.RESULTS: Cumulative organic dust exposure was inversely associated with COPD (adjusted rate ratios (RRadj (95% CIs) of 0.90 (0.82 to 0.99), 0.76 (0.69 to 0.84) and 0.52 (0.47 to 0.58) for intermediate-low, intermediate-high and high exposure quartiles, respectively, compared with the lowest exposure quartile). Lagging exposure 10 years was not consistently suggestive of an association between cumulative exposure and COPD; RRadj (95% CI): 1.05 (0.94 to 1.16), 0.92 (0.83 to 1.02) and 0.63 (0.56 to 0.70). Additional stratification by duration of employment showed no clear association between organic dust exposure and COPD except for the longer exposed (15-40 years) where an inverse association was indicated. Subgroup analyses showed that smoking had no impact on exposure-response estimates.CONCLUSIONS: Our findings show no increased risk of COPD with increasing occupational exposure to organic dust in the farming or wood industry.Potential residual confounding by smoking can, however, not be ruled out.

AB - OBJECTIVES: To study exposure-response relations between cumulative organic dust exposure and incident chronic obstructive pulmonary disease (COPD) among subjects employed in the Danish farming and wood industry.METHODS: We studied exposure-response relations between cumulative organic dust exposure and incident COPD (1997-2013) among individuals born during 1950-1977 in Denmark ever employed in the farming or wood industry (n=1 75 409). Industry-specific employment history (1964-2007), combined with time-dependent farming and wood industry-specific exposure matrices defined cumulative exposure. We used logistic regression analysis with discrete survival function adjusting for age, sex and calendar year. Adjustment for smoking status was explored in a subgroup of 4023 with smoking information available.RESULTS: Cumulative organic dust exposure was inversely associated with COPD (adjusted rate ratios (RRadj (95% CIs) of 0.90 (0.82 to 0.99), 0.76 (0.69 to 0.84) and 0.52 (0.47 to 0.58) for intermediate-low, intermediate-high and high exposure quartiles, respectively, compared with the lowest exposure quartile). Lagging exposure 10 years was not consistently suggestive of an association between cumulative exposure and COPD; RRadj (95% CI): 1.05 (0.94 to 1.16), 0.92 (0.83 to 1.02) and 0.63 (0.56 to 0.70). Additional stratification by duration of employment showed no clear association between organic dust exposure and COPD except for the longer exposed (15-40 years) where an inverse association was indicated. Subgroup analyses showed that smoking had no impact on exposure-response estimates.CONCLUSIONS: Our findings show no increased risk of COPD with increasing occupational exposure to organic dust in the farming or wood industry.Potential residual confounding by smoking can, however, not be ruled out.

KW - chronic obstructive pulmonary disease (copd)

KW - epidemiology

KW - occupational exposure

KW - organic dusts

U2 - 10.1136/oemed-2018-105323

DO - 10.1136/oemed-2018-105323

M3 - Journal article

VL - 76

SP - 105

EP - 113

JO - Occupational and Environmental Medicine

JF - Occupational and Environmental Medicine

SN - 1351-0711

IS - 2

ER -