Torben Sigsgaard

A clear urban-rural gradient of allergic rhinitis in a population-based study in Northern Europe

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

A clear urban-rural gradient of allergic rhinitis in a population-based study in Northern Europe. / Christensen, Stine Holmegaard; Timm, Signe; Janson, Christer; Benediktsdóttir, Bryndis; Forsberg, Bertil; Holm, Mathias; Jogi, Rain; Johannessen, Ane; Omenaas, Ernst; Sigsgaard, Torben; Svanes, Cecilie; Schlünssen, Vivi.

I: The Clinical Respiratory Journal, Bind 3, Nr. 33463, 2016, s. 33463.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Christensen, SH, Timm, S, Janson, C, Benediktsdóttir, B, Forsberg, B, Holm, M, Jogi, R, Johannessen, A, Omenaas, E, Sigsgaard, T, Svanes, C & Schlünssen, V 2016, 'A clear urban-rural gradient of allergic rhinitis in a population-based study in Northern Europe', The Clinical Respiratory Journal, bind 3, nr. 33463, s. 33463.

APA

Christensen, S. H., Timm, S., Janson, C., Benediktsdóttir, B., Forsberg, B., Holm, M., ... Schlünssen, V. (2016). A clear urban-rural gradient of allergic rhinitis in a population-based study in Northern Europe. The Clinical Respiratory Journal, 3(33463), 33463.

CBE

Christensen SH, Timm S, Janson C, Benediktsdóttir B, Forsberg B, Holm M, Jogi R, Johannessen A, Omenaas E, Sigsgaard T, Svanes C, Schlünssen V. 2016. A clear urban-rural gradient of allergic rhinitis in a population-based study in Northern Europe. The Clinical Respiratory Journal. 3(33463):33463.

MLA

Vancouver

Christensen SH, Timm S, Janson C, Benediktsdóttir B, Forsberg B, Holm M o.a. A clear urban-rural gradient of allergic rhinitis in a population-based study in Northern Europe. The Clinical Respiratory Journal. 2016;3(33463):33463.

Author

Christensen, Stine Holmegaard ; Timm, Signe ; Janson, Christer ; Benediktsdóttir, Bryndis ; Forsberg, Bertil ; Holm, Mathias ; Jogi, Rain ; Johannessen, Ane ; Omenaas, Ernst ; Sigsgaard, Torben ; Svanes, Cecilie ; Schlünssen, Vivi. / A clear urban-rural gradient of allergic rhinitis in a population-based study in Northern Europe. I: The Clinical Respiratory Journal. 2016 ; Bind 3, Nr. 33463. s. 33463.

Bibtex

@article{4550c36d2ece48d2a61179fd7e54a5d1,
title = "A clear urban-rural gradient of allergic rhinitis in a population-based study in Northern Europe",
abstract = "BACKGROUND: The protective effect of farm upbringing on allergic rhinitis is well known, but how upbringing in other environments influences the development of allergic rhinitis is scarcely investigated. The aim of this study was to investigate the association between place of upbringing and pet keeping in childhood and allergic rhinitis and nasal symptoms in adulthood.METHODS: The population-based Respiratory Health in Northern Europe study includes subjects from Denmark, Norway, Sweden, Iceland, and Estonia born in 1945-1973. This paper analyses 13,376 participants of the third study wave. Six categories of place of upbringing were defined: farm with livestock, farm without livestock, village in rural area, small town, city suburb, and inner city. Pets in the home at birth and during childhood were recorded. Data were analysed using adjusted logistic regression models.RESULTS: Livestock farm upbringing predicted less adult allergic rhinitis [odds ratio (OR) 0.68, 0.54-0.85] and nasal symptoms (OR 0.82, 0.68-0.99) than city upbringing, and an urban-rural gradient with decreasing risk per level of urbanisation was observed (OR 0.92, 0.88-0.94). Pets in the home at birth (OR 0.78, 0.68-0.88) and during childhood (OR 0.83, 0.74-0.93) were associated with less subsequent allergic rhinitis. Pet keeping did not explain the protective effect of place of upbringing.CONCLUSION: Risk of allergic rhinitis and nasal symptoms in adulthood was inversely associated with the level of urbanisation during upbringing. Pets at birth decreased the risk further, but did not explain the urban-rural gradient. Persistent beneficial effects of microbial diversity in early life might be an explanation for the findings.",
author = "Christensen, {Stine Holmegaard} and Signe Timm and Christer Janson and Bryndis Benediktsd{\'o}ttir and Bertil Forsberg and Mathias Holm and Rain Jogi and Ane Johannessen and Ernst Omenaas and Torben Sigsgaard and Cecilie Svanes and Vivi Schl{\"u}nssen",
year = "2016",
language = "English",
volume = "3",
pages = "33463",
journal = "Clinical Respiratory Journal",
issn = "1752-6981",
publisher = "Wiley-Blackwell Publishing, Inc",
number = "33463",

}

RIS

TY - JOUR

T1 - A clear urban-rural gradient of allergic rhinitis in a population-based study in Northern Europe

AU - Christensen, Stine Holmegaard

AU - Timm, Signe

AU - Janson, Christer

AU - Benediktsdóttir, Bryndis

AU - Forsberg, Bertil

AU - Holm, Mathias

AU - Jogi, Rain

AU - Johannessen, Ane

AU - Omenaas, Ernst

AU - Sigsgaard, Torben

AU - Svanes, Cecilie

AU - Schlünssen, Vivi

PY - 2016

Y1 - 2016

N2 - BACKGROUND: The protective effect of farm upbringing on allergic rhinitis is well known, but how upbringing in other environments influences the development of allergic rhinitis is scarcely investigated. The aim of this study was to investigate the association between place of upbringing and pet keeping in childhood and allergic rhinitis and nasal symptoms in adulthood.METHODS: The population-based Respiratory Health in Northern Europe study includes subjects from Denmark, Norway, Sweden, Iceland, and Estonia born in 1945-1973. This paper analyses 13,376 participants of the third study wave. Six categories of place of upbringing were defined: farm with livestock, farm without livestock, village in rural area, small town, city suburb, and inner city. Pets in the home at birth and during childhood were recorded. Data were analysed using adjusted logistic regression models.RESULTS: Livestock farm upbringing predicted less adult allergic rhinitis [odds ratio (OR) 0.68, 0.54-0.85] and nasal symptoms (OR 0.82, 0.68-0.99) than city upbringing, and an urban-rural gradient with decreasing risk per level of urbanisation was observed (OR 0.92, 0.88-0.94). Pets in the home at birth (OR 0.78, 0.68-0.88) and during childhood (OR 0.83, 0.74-0.93) were associated with less subsequent allergic rhinitis. Pet keeping did not explain the protective effect of place of upbringing.CONCLUSION: Risk of allergic rhinitis and nasal symptoms in adulthood was inversely associated with the level of urbanisation during upbringing. Pets at birth decreased the risk further, but did not explain the urban-rural gradient. Persistent beneficial effects of microbial diversity in early life might be an explanation for the findings.

AB - BACKGROUND: The protective effect of farm upbringing on allergic rhinitis is well known, but how upbringing in other environments influences the development of allergic rhinitis is scarcely investigated. The aim of this study was to investigate the association between place of upbringing and pet keeping in childhood and allergic rhinitis and nasal symptoms in adulthood.METHODS: The population-based Respiratory Health in Northern Europe study includes subjects from Denmark, Norway, Sweden, Iceland, and Estonia born in 1945-1973. This paper analyses 13,376 participants of the third study wave. Six categories of place of upbringing were defined: farm with livestock, farm without livestock, village in rural area, small town, city suburb, and inner city. Pets in the home at birth and during childhood were recorded. Data were analysed using adjusted logistic regression models.RESULTS: Livestock farm upbringing predicted less adult allergic rhinitis [odds ratio (OR) 0.68, 0.54-0.85] and nasal symptoms (OR 0.82, 0.68-0.99) than city upbringing, and an urban-rural gradient with decreasing risk per level of urbanisation was observed (OR 0.92, 0.88-0.94). Pets in the home at birth (OR 0.78, 0.68-0.88) and during childhood (OR 0.83, 0.74-0.93) were associated with less subsequent allergic rhinitis. Pet keeping did not explain the protective effect of place of upbringing.CONCLUSION: Risk of allergic rhinitis and nasal symptoms in adulthood was inversely associated with the level of urbanisation during upbringing. Pets at birth decreased the risk further, but did not explain the urban-rural gradient. Persistent beneficial effects of microbial diversity in early life might be an explanation for the findings.

M3 - Journal article

VL - 3

SP - 33463

JO - Clinical Respiratory Journal

JF - Clinical Respiratory Journal

SN - 1752-6981

IS - 33463

ER -