Tommy Kjærgaard Nielsen

Safety of percutaneous renal cryoablation: an international multicentre experience from the EuRECA retrospective percutaneous database

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • J Garnon, Department of Interventional Radiology, Nouvel Hôpital Civil, 1, place de l'hôpital, 67096, Strasbourg Cedex, France. juliengarnon@gmail.com.
  • ,
  • M J Van Strijen, Department of Radiology, St. Antonius Hospital, Niewegein, the Netherlands.
  • ,
  • Tommy Kjærgaard Nielsen
  • A J King, Department of Radiology, University Hospital Southampton NHS Trust, Tremona Road, Southampton, SO16 6YD, UK.
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  • A D Montauban Van Swijndregt, Department of Urology, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091 AC, Amsterdam, Netherlands.
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  • R L Cazzato, Department of Interventional Radiology, Nouvel Hôpital Civil, 1, place de l'hôpital, 67096, Strasbourg Cedex, France.
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  • P Auloge, Department of Interventional Radiology, Nouvel Hôpital Civil, 1, place de l'hôpital, 67096, Strasbourg Cedex, France.
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  • C Rousseau, Clinical Investigation Center INSERM 1414, University Hospital of Rennes and University of Rennes, Rennes, France.
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  • D Dalili, Department of Radiology, Guy's and St. Thomas' Hospitals NHS Foundation Trust, London, UK.
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  • F X Keeley, Department of Urology, Bristol Urological Institute, Bristol, UK.
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  • B W Lagerveld, Department of Urology, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1091 AC, Amsterdam, Netherlands.
  • ,
  • D J Breen, Department of Radiology, University Hospital Southampton NHS Trust, Tremona Road, Southampton, SO16 6YD, UK.

OBJECTIVE: To investigate the safety profile of percutaneous cryoablation of renal tumours < 7 cm, utilising data extracted from an international multicentre registry.

MATERIALS AND METHODS: A retrospective review of all immediate and delayed complications from a multicentre database was performed and was categorised according to the Clavien-Dindo classification. Statistical analysis was performed for both overall complications (all Clavien-Dindo) and major complications (Clavien-Dindo 3 to 5). The following criteria were identified as potential predictive factors for complications: centre number, modality of image guidance, tumour size (≤ 4 cm vs. > 4 cm), number of tumours treated in the same session (1 vs. > 1) and tumour histology.

RESULTS: A total of 713 renal tumours underwent ablation in 647 individual sessions. In 596 of the cases, one tumour was treated; in the remaining 51 cases, several tumours were treated per session. Mean lesion size was 2.8 cm. Fifty-four complications (Clavien-Dindo 1 to 5) occurred as a result of the 647 procedures, corresponding to an overall complication rate of 8.3%. The most frequent complication was bleeding (3.2%), with 9 cases (1.4%) requiring subsequent treatment. The rate of major complication was 3.4%. The only statistically significant prognostic factor for a major complication was a tumour size > 4 cm.

CONCLUSION: Percutaneous renal cryoablation is associated with a low rate of complications. Tumours measuring more than 4 cm are associated with a higher risk of major complications.

KEY POINTS: • Percutaneous kidney cryoablation has a low rate of complications. • Bleeding is the most frequent complication. • A tumour size superior to 4 cm is a predictive factor of major complication.

OriginalsprogEngelsk
TidsskriftEuropean Radiology
Vol/bind29
Nummer11
Sider (fra-til)6293-6299
Antal sider7
ISSN0938-7994
DOI
StatusUdgivet - nov. 2019

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