Tommy Kjærgaard Nielsen

Long-term survival of patients treated with laparoscopic cryoablation for small renal tumours

Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

Introduction
Cryoablation of small renal tumours was initially introduced more than two decades ago and has been practiced at Aarhus University Hospital (AUH) since 2005. The modality aims to offer a minimal invasive approach, while maintaining an oncological outcome comparable to that of partial nephrectomy.
Cryoablation was initially performed as a laparoscopic assisted procedure, but has in recent years evolved into a CT-guided procedure in most cases.
We present a long-term survival analysis of patients that underwent laparoscopic assisted cryoablation (LAC) of biopsy proven small renal tumours.

Methods
A retrospective review of 184 patients who during a 9-year period underwent LAC for a biopsy proven small renal tumour at AUH.

Results
A total of 179 patients were included in the study. The mean image follow-up time was 44 months (IQR 19-62).
A total of 21 patients (12%) were diagnosed with initial unablated tumour, 5 patients (3%) were diagnosed with local recurrence and 5 patients (3%) were diagnosed with metastatic disease. The estimated 3 and 5-year disease-free survival rate was 85% and 79%. The estimated 3 and 5-year overall survival rate was 89% and 82%.

Regarding the cancer-free survival analysis 83% had no event in the follow-up period, 21% had incomplete ablation and both local reccurrence and metastatic disease represented 3%. However, a large proportion of recurrence was within the first year and might represent incomplete ablation.
The overall survival analysis shows 128 (71%) patients still alive at the conclusion of the analysis, 4% (n=6) cancer specific deaths and 25% died of other courses.

Discussion
We present long term survival data of patients treated with laparoscopic cryoablation. The disease free survival is excellent, but the kaplann-meier plot reveals that incomplete ablation warrants close follow-up.
This is the longest survival data that has been presented after laparoscopic cryablation.
OriginalsprogEngelsk
Udgivelsesår2019
StatusUdgivet - 2019
BegivenhedNUF 2019 - , Island
Varighed: 5 jun. 2019 → …

Konference

KonferenceNUF 2019
LandIsland
Periode05/06/2019 → …

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