Tine Brink Henriksen

Parental subfertility and hypospadias and cryptorchidism in boys: results from two Danish birth cohorts

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

OBJECTIVE: To study if parental subfertility is related to the occurrence of the male genital anomalies, cryptorchidism and hypospadias.

DESIGN: Population-based cohort study.

SETTING: Not applicable.

PATIENT(S): A total of 80,220 singleton boys and their mothers from the Danish National Birth Cohort and the Aarhus Birth Cohort.


MAIN OUTCOME MEASURE(S): The two congenital anomalies; cryptorchidism and hypospadias, registered within the Danish National Patient Register up until December 31, 2012.

RESULT(S): By means of Cox regression analyses, we found no associations between waiting time-to-pregnancy (TTP) and cryptorchidism or hypospadias among those who conceived spontaneously. The highest hazard ratio for cryptorchidism was seen among boys of couples with a TTP>12 months who conceived after fertility treatment (adjusted hazard ratio [aHR] 1.19, 95% confidence interval 0.92-1.55). For hypospadias, we found that boys of couples with a TTP>12 months who conceived after fertility treatment, had a 71% higher risk of hypospadias (aHR 1.71, [95% confidence interval 1.24-3.36]) as compared with boys of couples with a TTP<5 months.

CONCLUSION(S): The findings from this study showed that boys of couples with TTP>12 months who conceived after fertility treatment, had a higher occurrence of hypospadias than boys conceived spontaneously of couples with a short TTP. Among those who conceived spontaneously, TTP was not associated with hypospadias or cryptorchidism. These findings indicate that fertility treatment or severity of subfertility is related to hypospadias.

TidsskriftFertility and Sterility
Sider (fra-til)826-832
Antal sider7
StatusUdgivet - okt. 2018

Bibliografisk note

Copyright © 2018 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Se relationer på Aarhus Universitet Citationsformater

ID: 135451945