Tine Brink Henriksen

Fertility treatment and childhood type 1 diabetes mellitus: a nationwide cohort study of 565,116 live births

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

OBJECTIVE: To investigate the association between specific types of fertility treatment and childhood type 1 diabetes mellitus.

DESIGN: Nationwide birth cohort study.

SETTING: Not applicable.

PATIENT(S): All pregnancies resulting in a live-born singleton child in Denmark from 1995 to 2003.

INTERVENTION(S): Not applicable.

MAIN OUTCOME MEASURE(S): Childhood type 1 diabetes mellitus identified from redeemed prescriptions for insulin until 2013.

RESULT(S): The study included 565,116 singleton pregnancies. A total of 14,985 children were conceived by ovulation induction or intrauterine insemination, and 8,490 children were conceived by in vitro fertilization or intracytoplasmic sperm injection. During the follow-up period, 2,011 (0.4%) children developed type 1 diabetes mellitus. The primary analyses showed no association between fertility treatment and childhood type 1 diabetes mellitus. In secondary analyses, ovulation induction or intrauterine insemination with follicle-stimulating hormone was associated with an increased risk of type 1 diabetes mellitus (hazard ratio 3.22; 95% confidence interval 1.20 to 8.64). No clear associations were seen with other types of fertility treatment or with specific treatment indications.

CONCLUSION(S): No association between fertility treatment and childhood type 1 diabetes mellitus was found. Ovulation induction or intrauterine insemination with follicle-stimulating hormone may be associated with an increased risk of childhood type 1 diabetes mellitus. However, this finding may be due to chance or to confounding by indication and thus requires further investigation.

OriginalsprogEngelsk
TidsskriftFertility and Sterility
Vol/bind106
Nummer7
Sider (fra-til)1751-1756
Antal sider6
ISSN0015-0282
DOI
StatusUdgivet - dec. 2016

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