Tine Brink Henriksen

Birth by cesarean section in relation to adult offspring overweight and biomarkers of cardiometabolic risk

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • S Hansen, Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Research Centre for Prevention and Health, The Capital Region of Denmark, Copenhagen, Denmark., Danmark
  • T I Halldorsson, Unit for Nutrition Research, Landspitali - The National University Hospital of Iceland and Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland., Centre for Fetal Programming, Statens Serum Institut, Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Island
  • S F Olsen, Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. katharina.nimptsch@mdc-berlin.de.
  • ,
  • D Rytter
  • B H Bech
  • C Granström, Centre for Fetal Programming, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Danmark
  • T B Henriksen
  • J E Chavarro, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA., USA

BACKGROUND: Birth by Cesarean section (C-section) may increase the risk for non-communicable diseases. We aimed to examine the relation of birth by C-section with offspring overweight and markers of cardiometabolic risk in a prospective observational cohort with 20 years of follow-up.

METHODS: The Danish Fetal Origins Cohort enrolled 965 pregnant women in 1988-1989. In 2008, a follow-up study of the offspring was completed. The offspring were invited to participate in a clinical examination with measurements of anthropometry and a fasting blood sample (n=443). In addition, 252 offspring completed a self-administered questionnaire with questions on height and weight, leaving us with a study sample of 695 offspring. Offspring overweight at 20 years was defined as body mass index (BMI)⩾25 kg m-2. We also analyzed blood pressure and fasting blood samples for cardiometabolic risk factors including insulin, leptin and adiponectin, and lipid concentrations.

RESULTS: In the cohort, 7% were born by C-section, and at age 20 years, 18% of the offspring had a BMI ⩾25 kg m-2. Birth by C-section was associated with increased odds of overweight or obesity at 20 years (Odds ratio=2.17 (95% confidence interval (CI): 1.10, 4.27)) after adjustment for potential confounders. Birth by C-section was also associated with higher serum concentrations of total cholesterol (8.5%, 95% CI: 1.1-16.5), low-density lipoprotein cholesterol (12.6%, 95% CI: 1.0, 25.5), leptin (73.1%, 95% CI: 5.9, 183.1) and Apolipoprotein B (0.08 g l-1, 95% CI: 0.04, 0.15). In contrast, birth by C-section was not related to blood pressure or serum concentrations of insulin, adiponectin, triglycerides, high-density lipoprotein or Apolipoprotein A.

CONCLUSION: Birth by C-section was associated with higher frequency of dysmetabolic traits in offspring independently of shared risk factors. Further research aimed at replicating these findings and elucidating the underlying biological mechanisms of this relation is needed.International Journal of Obesity advance online publication, 22 August 2017; doi:10.1038/ijo.2017.175.

OriginalsprogEngelsk
TidsskriftInternational journal of obesity (2005)
Vol/bind42
Nummer1
Sider (fra-til)15-19
Antal sider5
ISSN0307-0565
DOI
StatusUdgivet - jan. 2018

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