Tine Brink Henriksen

Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Katrine Strandberg-Larsen, Section for Social Medicine, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, Postbox 2099, 1014, Copenhagen K, Denmark. ksla@sund.ku.dk.
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  • Gry Poulsen, Section for Social Medicine, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, Postbox 2099, 1014, Copenhagen K, Denmark.
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  • Bodil Hammer Bech
  • Leda Chatzi, Department of Social Medicine, Faculty of Medicine, University of Crete, Rethimno, Greece.
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  • Sylvaine Cordier, National Institute of Health and Medical Research (INSERM), U1085-IRSET, University of Rennes, Rennes, France.
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  • Maria Teresa Grønning Dale, Department of Psychology, University of Oslo, Oslo, Norway.
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  • Marieta Fernandez, The Spanish Biomedical Research Centre in Epidemology and Public Health (CIBERESP), Health Institute Carlos III, Madrid, Spain; Andalusian School of Public Health. Biomedical Research Institute of Granada; University Hospital of Granada/Granada University, Granada, Spain;
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  • Tine Brink Henriksen
  • Vincent Wv Jaddoe, Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
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  • Manolis Kogevinas, ISGlobal, Centre for Research in Environmental Epidemiology (CREAL) , Barcelona, Catalonia, Spain.
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  • Claudia J Kruithof, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
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  • Morten Søndergaard Lindhard
  • Per Magnus, Norwegian Institute of Public Health, Oslo, Norway.
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  • Ellen Aagaard Nohr, Research Unit for Gynaecology and Obstetrics, Institute of Clinical Research, University of Southern Denmark, 5000 Odense C, Denmark
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  • Lorenzo Richiardi, Unit of Cancer Epidemiology, AO Citta' della Salute e della Scienza, Department of Medical Sciences, University of Turin and Center for Cancer Prevention (CPO-Piemonte), 10126 Turin, Italy.
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  • Clara L Rodriguez-Bernal, Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Tenerife, Spain.
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  • Florence Rouget, National Institute of Health and Medical Research (INSERM), U1085-IRSET, University of Rennes, Rennes, France.
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  • Franca Rusconi, Unit of Epidemiology, Meyer Children's University Hospital, Florence, Italy.
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  • Martine Vrijheid, CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
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  • Anne-Marie Nybo Andersen, Section for Social Medicine, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, Postbox 2099, 1014, Copenhagen K, Denmark.

Women who drink light-to-moderately during pregnancy have been observed to have lower risk of unfavourable pregnancy outcomes than abstainers. This has been suggested to be a result of bias. In a pooled sample, including 193 747 live-born singletons from nine European cohorts, we examined the associations between light-to-moderate drinking and preterm birth, birth weight, and small-for-gestational age in term born children (term SGA). To address potential sources of bias, we compared the associations from the total sample with a sub-sample restricted to first-time pregnant women who conceived within six months of trying, and examined whether the associations varied across calendar time. In the total sample, drinking up to around six drinks per week as compared to abstaining was associated with lower risk of preterm birth, whereas no significant associations were found for birth weight or term SGA. Drinking six or more drinks per week was associated with lower birth weight and higher risk of term SGA, but no increased risk of preterm birth. The analyses restricted to women without reproductive experience revealed similar results. Before 2000 approximately half of pregnant women drank alcohol. This decreased to 39% in 2000-2004, and 14% in 2005-2011. Before 2000, every additional drink was associated with reduced mean birth weight, whereas in 2005-2011, the mean birth weight increased with increasing intake. The period-specific associations between low-to-moderate drinking and birth weight, which also were observed for term SGA, are indicative of bias. It is impossible to distinguish if the bias is attributable to unmeasured confounding, which change over time or cohort heterogeneity.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Epidemiology
Vol/bind32
Nummer9
Sider (fra-til)751–764
ISSN0393-2990
DOI
StatusUdgivet - sep. 2017

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