Thomas Vorup-Jensen

Interleukin 20 protein locates to distinct mononuclear cells in psoriatic skin

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  • Rikke Bech, Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
  • ,
  • Kristian Otkjaer, Danmark
  • Svend Birkelund, Danmark
  • Thomas Vorup-Jensen
  • Ralf Agger, Danmark
  • Claus Johansen
  • Lars Iversen
  • Knud Kragballe, Danmark
  • John Rømer
We previously demonstrated that mRNA for the pro-inflammatory cytokine interleukin 20 (IL-20) is expressed in suprapapillary keratinocytes of lesional psoriatic skin. Here, we describe the distribution of IL-20 protein and the identity of the IL-20-positive cells in lesional psoriatic skin. We found that the main part of IL-20 immunoreactivity is present in mononuclear cells of the dermal papillae, and that the IL-20 positive cells located n the papillae were Langerin+, CD1a+, CD4+, and CD303+. These cells might be immature DC. In situ hybridization for IL-20 mRNA on non-lesional psoriatic skin, ex vivo stimulated with IL-1β revealed a co-localization between IL-20 mRNA and the keratinocyte marker CK14. No IL-20 mRNA was detected in the dermal mononuclear cells. Our results suggest that IL-20 is produced by keratinocytes, released into the epidermis, and then possibly taken up by papillary mononuclear cells. Our study supports that IL-20 is involved in the pathogenesis of psoriasis. This article is protected by copyright. All rights reserved.
OriginalsprogEngelsk
TidsskriftExperimental Dermatology Online
ISSN1600-0625
DOI
StatusUdgivet - 13 mar. 2014

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