Institut for Biomedicin

Thomas Vorup-Jensen

Decreased plasma levels of soluble CD18 link leukocyte infiltration with disease activity in spondyloarthritis

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Spondyloarthritis (SpA) comprises a group of diseases often associated with HLA-B27 and characterized by inflammation of the entheses and joints of the axial skeleton. The inflammatory process in SpA is presumably driven by innate immune cells but still poorly understood. Thus, new tools for monitoring and treating inflammation are needed. The family of CD18 integrins is pivotal in guiding leukocytes to sites of inflammation and CD18 hypomorphic mice develop a disease resembling SpA. Previously, we demonstrated altered soluble CD18 (sCD18) complexes in the blood and synovial fluid of arthritis patients to have anti-inflammatory functions. Here, we study the mechanisms for these alterations and their association with SpA disease activity.
TidsskriftArthritis research & therapy
Sider (fra-til)R42
StatusUdgivet - 4 feb. 2014

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