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Theis Muncholm Thillemann
Microdialysis for the Assessment of Intervertebral Disc and Vertebral Cancellous Bone Metabolism in a Large Porcine Model
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157874/pdf/in_vivo-34-527.pdf
Forlagets udgivne version
DOI
- https://doi.org/10.21873/invivo.11804
Forlagets udgivne version
- Mats Bue
- Pelle Hanberg
- Maja B Thomassen
- Mikkel Tøttrup, Aalborg Universitet ,
- Theis M Thillemann
- Kjeld Søballe ,
- Hanne Birke-Sørensen
BACKGROUND/AIM: It remains challenging to evaluate the in vivo pathophysiological biochemical characteristics in spine tissue, due to lack of an applicable model and feasible methods. The aim of this study was to apply microdialysis for the assessment of basic metabolites from the C3-C4 intervertebral disc, C3 vertebral cancellous bone and subcutaneous adipose tissue in a large porcine model.
MATERIALS AND METHODS: In 7 pigs, glucose, pyruvate, lactate and glycerol concentrations were evaluated in an 8-hour sampling period.
RESULTS: The mean lactate/pyruvate (L/P) ratios for the intervertebral disc and vertebral cancellous bone were comparable and exceeded the ischemic cut-off value of 25 for the entire sampling interval. For subcutaneous adipose tissue, the L/P ratio was below the ischemic cut-off.
CONCLUSION: This exploratory study confirms previous findings of ischemia in bone and the intervertebral disc. This encourages new microdialysis study designs in spine tissue employing large porcine models to create new knowledge and a greater understanding of the metabolism and pathogenesis in spine tissue.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | In Vivo |
| Vol/bind | 34 |
| Nummer | 2 |
| Sider (fra-til) | 527-532 |
| Antal sider | 6 |
| ISSN | 0258-851X |
| DOI | |
| Status | Udgivet - 2020 |
Bibliografisk note
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
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