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Suresh Rattan

Lektor

Profile photoSuresh Rattan, Ph.D., Dr.scient.
Lektor
Laboratoriet for Cellulær Aldring (LCA)
Institut for Molekylærbiologi og Genetik
Postaddresse:
Gustav Wieds Vej 10
Bygn. 3135, Vær: 207
8000 Aarhus C
Danmark

E-mail: rattan@mbg.au.dk
Mobil: 28992496
Telefon: +4587155436

Personal information

• Name: SURESH I. S. RATTAN
• Birth data: 1955; Amritsar, India
• Contact information: Laboratory of Cellular Ageing (LCA),
Department of Molecular Biology and Genetics, Aarhus University,
Gustav Wieds Vej 10C, 8000 Aarhus – C; Building 3135; Room 207;
Phones: landline: +45 8715 5436; mobile: +45 2899 2496;
Emails: rattan@mbg.au.dk; sureshrattan@gmail.com

Position

• from Feb. 2011; Associate Professor
• Sept. 2009- Jan. 2011; Associate Professor
• 2004 – 2009; Research Professor
• 1995 – 2004; Research Associate Professor
• 1984 – 1995; Post-doc; Research Assistant Professor

Education

• Dr. scient. (D.Sc.) 1995, Aarhus University, Denmark.
• Ph.D. 1982, National Institute for Medical Research, Mill Hill, London, UK.
• M.Phil. 1979, Jawaharlal Nehru University, New Delhi, India.
• M.Sc. 1977; Guru Nanak Dev University, Amritsar, India.

Scientific summary

• Area of research: Ageing and health of normal human cells in culture, using a variety of normal human cells including skin fibroblasts, keratinocytes, endothelial cells, osteoblasts, bone marrow stem cells, and telomerase immortalised mesenchymal stem cells. Development of the concept of ageing genes, gerontogenes. Discovering the ageing-modulatory effects of cytokinins kinetin and zeatin. Testing and application of the concept of mild stress-induced hormesis and hormetins in ageing research and interventions, and development of novel natural and sythetic nutrional hormetins.

Bibliometric summary (as per December 2016)

•Citation indices (from Google Scholar)
•Total citations: 8254
•h-index: 49
•i10-index 139

•Research papers, review articles, book chapters published : 235
•Abstracts in international meetings: more than 100

Most cited papers (with at least 175 or more citations; as per 01 April 2016)

•Simonsen, J.L., Rosada, C., Serak, N., Justesen, J., Stenderup, K., Rattan, S.I.S., Jensen, T.G. and Kassem, M. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nature Biotechnology, 20, 592-596, 2002. Number of times cited: more than 650 times
•Calabrese, E.J, + 50 other authors, including Rattan, S.I.S. Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework. Toxicology and Applied Pharmacology, 22: 122-128, 2007. Number of times cited: more than 350 tiems
•Riis, B., Rattan, S.I.S., Clark, B.F.C. and Merrick, W.C. Eukaryotic protein elongation factors. Trends in Biochemical Sciences (TIBS), 15, 420-424, 1990. Number of times cited: more than 300 times
•Rattan, S.I.S. Hormesis in aging. Ageing Research Reviews, 7, 62-78, 2008. Number of times cited: 257
•Rattan, S.I.S. Theories of biological aging: genes, proteins and free radicals. Free Radical Research, 40: 1230-1238, 2006; Number of times cited: 256
•Stenderup, K., Justesen, J., Eriksen, E.F., Rattan, S.I.S. and Kassem, M. Number and proliferative capacity of osteogenic stem cells are maintained during aging and in patients with osteoporosis. Journal of Bone and Mineral Research, 16, 1120-1129, 2001. Number of times cited: 228
•Rattan, S.I.S. Synthesis, modifications and turnover of proteins during cellular aging. Experimental Gerontology, 31, 33-47, 1996. Number of times cited: 198
•Verbeke, P., Fonager, J., Clark, B.F.C. and Rattan, S.I.S. Heat shock response and ageing: mechanisms and applications. Cell Biology International, 25, 845-857, 2001. Number of times cited: 184
•Rattan, S.I.S. and Clark, B.F.C. Kinetin delays the onset of ageing characteristics in human fibroblasts. Biochemical and Biophysical Research Communications, 201, 665-672, 1994. Number of times cited: 177
•Hercus, M., Loeschcke, V. and Rattan, S.I.S. Extension of longevity of Drosophila by repeated mild heat stress exposures. Biogerontology, 4, 149-156, 2003. Number of times cited: 175

Patents

Suresh I.S. Rattan. Method and composition for ameliorating the adverse effects of aging.
• United States, Patent, No., 5,371,089; Granted: December 6, 1994
• United States, Patent, No., 5,602,139; Granted: March 25, 1997
• United States, Patent, No., 5,614,407; Granted February 11, 1997
• Argentina, Patent No. 250273; Granted: January 28, 1997
• Australia, Patent No. 666836; Granted October 21, 1997
• Canada, Patent No. 1,339,503; Granted: October 21, 1997
• Israel, Patent No. 98204; Granted February 12, 1995
• India, Patent No. 172210; Granted May 29, 1991
• Japan, decided to grant: September 22, 2000
• Korea, Patent No.; Granted: February 22, 1999
• Mexico, Patent No. 178834; Granted: July 21, 1995
• New Zealand, Patent No. 238210; Granted: March 4, 1996
• New Zealand, Patent No. 247836; Granted: August 8, 1997
• Taiwan, Patent No. 076376; Granted: May 23, 1996

Books

•Cellular Ageing and Rreplicative Senescence, editors: Editors: Suresh I.S. Rattan and Leonard Hayflick, Springer Publishers (2016).

•Hormesis in Health and Disease, Editors: Suresh IS Rattan and Eric Le Bourg, CRC Press, Boca Raton, Florida, USA (2014) ISBN: 978-148-2205459

•Brain Aging and Therapeutic Interventions. Editors: Mahendra K. Thakur and Suresh I.S. Rattan; Springer Publ., (2012). ISBN: 978-94-007-5236-8; ISBN (eBook): 978-94-007-5237-5

•Calorie Restriction, Aging and Longevity Editors: A. Everitt, S.I.S. Rattan, D. Le Couteur and R. de Cabo; Springer, Dordrecht, The Netherlands; 2010; ISBN 978-90-481-8555-9 e-ISBN 978-90-481-8556-6

•“DOSE RESPONSE”(volume 8, issue 1, 2010; special issue), Guest editors: Eric Le Bourg and Suresh I.S. Rattan

•Mild Stress and Healthy Aging: Applying Hormesis in Aging Research and Intervention; Editors: Eric le Bourg and Suresh I.S. Rattan; Springer Publishers, Dordrecht, The Netherlands ISBN: 978-1-4020-6868-3 (2008).

•Healthy Aging and Longevity; Editors: Noah J. Weller and Suresh I.S. Rattan; Annals of the New York Academy of Sciences, volume 1114; New York, USA (2007).

•Biogerontology: Mechanisms and Interventions; Editors: Suresh I.S. Rattan and Serif Akman; Annals of the New York Academy of Sciences, volume 1100; New York, USA (2007).

•Understanding and Modulating Aging; Editors: Suresh I.S. Rattan, Peter Kristensen and Brian Clark; Annals of the New York Academy of Sciences, volume 1067; New York, USA (2006).

•Prevention and Treatment of Age-related Diseases; Editors: Suresh I.S. Rattan and Moustapha Kassem Springer Publishers, Dordrecht, The Netherlands ISBN: 10-1-4020-4884-X (2006).

•Aging Interventions and Therapies; Editor: Suresh I.S. Rattan; World Scientific Books, Singapore; 2005; ISBN:981-256-084-X

•Modulating aging and longevity; Editor: Suresh I.S. Rattan; Kluwer Academic Publishers, 2003, Dordrecht/Boston/London ISBN: 1-4020-1369-8 2.

•Molecular Gerontology: Research Status and Strategies; Editors: Suresh I.S. Rattan and Olivier Toussaint; Plenum Press, London, 1996. ISBN: 0-306-45491-2

Popular science and general educational books for children

• E=GMC2 formlen for evig ungdom (E =GMC2, the formula for eternal youth – a popular science book in Danish for school and college students, with accompanying CD ROM; Malling Beck Publishers, Copenhagen); awarded the Education Prize 2003, from the Danish Education Ministry.

• “Where’s Baba Gone?” a story-based book on the science and philosophy of life, ageing and death, in Punjabi and English; Published in India; 1997, 2002, 2009; in English 1999, 2002, 2011; in Hindi (2012); in Polish 2009 (Dokad Odchodzisz? translated by Monika Kowaleczko-Szumowska) as an EU-supported project on Science and Humanities, (ACUME2); in Romanian (UNDE SA-DUS BABA; 2012).


Membership of societies, selected academic distinctions & other merits

•Outstanding Career Achievement Award, International Dose Response Society, UMass, Amherst, USA (2017).
- Honorary Professor, Faculty of Science, Palacky University, Olomouc, Czech Republic (2012-2016)
•Lord Cohen Medal in Gerontology (2011), from the British Society for Research on Ageing (BSRA).
•Honorary Doctorate from the Russian Academy of Medical Sciences (St. Petersburg branch), 2010.
•Founder and Editor-in-Chief, Biogerontology (from 2000, an international peer-reviewed journal, Springer Publishers).
•President, Biological Section, International Association of Gerontology and Geriatrics (IAGG)-European Region (2011-2015; and 2015-2019)
•Member, International Dose Response Society, USA (from 2006)
•Member, Danish Natural Science Academy (DNA; from 2004).
•Life Member, the Cell Stress Society, USA (from 1999).
•Life Member, Association of Gerontology, India (from 1983).
•PhD/DSc examiner for universities in Denmark, Sweden, Italy, UK, India.
•Member of various grant evaluation committees in UK, USA, Germany, The Netherlands, Switzerland, Austria, Ireland, Singapore, Russia, Georgia, Estonia, Turkey, and the European Research Council (ERC).

Current research funding

• EU’s Horizon-2020 funded research and innovation action “Ageing with elegans” (grant agreement No 633589); from May 2015 to April 2020; our share: 100,000-Euros per year; my time contribution ca. 10%

Teaching and supervision

PhDs
1. Anastassia Derventzi (Greece); Ageing: the failure of homeostasis. (July 1992; co-supervision with Brian Clark).
2. Marie Kveiborg (Denmark); Cellular and molecular mechanisms of bone loss in aging. (May 2000; co-supervision with Moustapha Kassem).
3. Karin Stendrup (Denmark); Effect of age on human bone marrow stromal cells and their potential use in gene and cell therapy. (January 2002; co-supervision with Moustapha Kassem).
4. Jeannette Justesen (Denmark); Investigations of the relationship between adipocyte and osteoblast differentiation. (May 2002; co-supervision with Moustapha Kassem).
5. Ripudaman Singh (India); Association of heat shock protein 70 genes with human aging, longevity, survival and stress response. (March 2006; co-supervision with Steen Kølvraa).
6. Dino Demirovic (Denmark); Establishing stress response profiles in ageing human cells as markers of health. (August 2015).

MSc/Cand.scient.
1. Jens Cavallius (Denmark); Activity estimation and properties of mammalian elongation factor 1a. (March 1986).
2. Bent Riis (Denmark); Studies on elongation factor 2 in eukaryotic protein synthesis. (August 1990).
3. Lise Svendsen (Denmark); Garlic and ageing: cellular and molecular studies on the effects of garlic on human skin fibroblasts during ageing. (April 1992).
4. Marianne Glenting (Denmark): Ageing of Human Epidermal Keratinocytes: a study of cellular growth, longevity and macromolecular characteristics (Jan. 1993)
5. Lisbeth Ankersen (Denmark); Ageing of human trabecular osteoblasts. (June 1994).
6. Lars H. Østergaard (Denmark); Applications of new two-dimensional electrophoresis: use of immobilized pH gradients as a tool for characterisation of proteins. (June 1994).
7. Hanne Norsgaard (Denmark); Ageing and differentiation in human keratinocytes. (May 1997).
8. Anders Olsen (Denmark); A study of the antioxidant properties of kinetin in vitro and in vivo. (March 1999).
9. Susanne Mogensen (Denmark); The protein universe of human skin keratinocytes undergoing differentiation and ageing in vitro. (August 2000).
10. Lakshman Sodagam (India); Gerontomodulatory effects of zeatin on human skin fibroblasts undergoing ageing in vitro. (August 2004).
11. Regina Gonzalez Dosal (Spain); Analysis of glycation on the proteasome during ageing using phage displayed antibodies. (January 2005).
12. David C. Kraft (Denmark); Regulation of proteasome activity by heat shock, proteasomal inhibition and oxidative stress in human cells. (June 2005).
13. Elise R. Nielsen (Denmark); Heat shock-induced alterations in MAP kinases during cellular aging in vitro. (August 2005).
14. Rehab E. Ali (Egypt); Hormetic modulation of age-related changes in human keratincytes: effects of heat shcok and curcumin. (September 2006).
15. Ulrich Berge (Germany); Modulation of differentiation of normal human keratinocytes undergoing replicative senescence in vitro. (November 2006).
16. Mari Sild (Estonia); Individual variations in the expression of Werner gene in normal individuals. (September 2007; co-supervision with Bjørn Nexø).
17. Henrik Sejersen (Denmark); Dicarbonyl-induced accelerated aging in human fibroblasts. (September 2007).
18. Tina Hansen (Denmark); Age-related changes in the proteasomal activities in C. elgans, and its modulation by heat shock. (December 2007; co-supervision with Anders Olsen, Buck Institute, USA).
19. Rune Nørggard (Denmark); Improved differentiation of telomerase-immortalised human bone marrow stem cells by mild heat stress (March 2008).
20. Iben Lundgaard (Denmark); Mutation of putative phosphorylation sites of ALG-2. (May 2008; co-supervision with Martin Berchtold, University of Copenhagen).
21. Simon Larsen (Denmark); Glyoxal-induced acclerated ageing in telomerase-immortalised human bone marrow stem cells. (June 2009).
22. Dino Demirovic (Denmark); Wound healing during cellular ageing and its hormetic modulation with curcumin. (October 2009).
23. Peter Jørgensen (Denmark): Testing the rejuvenating potential of young ECM on human skin fibroblasts (November 2013).
24. Evelyn Samuel (Denmark): Identifying partners of neuroglobulins in psychiatric disorders. (Supervision together with: Heidi Kaastrup Müller, Department of Clinical Medicine, AU Hospital); started February 2016)

Bachelor projects
1. Dino Demirovic (Denmark); Molecular basis of hormesis in ageing. (theoretical project; April 2007).
2. Renuka Jeyaras (Denmark); Nucleic acids and the damages during ageing. (theoretical project; Feb 2009).
3. Ea Vinten (Denmark); Protein modification and during ageing. (theoretical project; was due sometime in 2009; but finally finished in March 2011).
4. Ole Jørgensen (Denmark); Modulation of wound healing during ageing. (research project; started in late 2008, finished January 2011).
5. Aske Rask (Denmark); Flavanoids and polyphenols – do they have anti-ageing effects? (theoretical project; June 2010).
6. Sara Elisabeth Eriksen (Denmark); Aldring af huden: molekylær basis og mekanismer (theoretical project; August 2010).
7. Elisabeth Kristoffersen (Denmark); Hypoxia-induced hormetic modulation of angiogenesis in human endothelial cells. (research project; August 2010).
8. Majda Ashraf (Denmark); Mitochondria in ageing (theoretical project, September 2010).
9. Peter Jørgensen (Denmark): Modulating cellular mobility in human stem cells (research project; June 2011).
10. Hoger Amin (Denmark): Determining the dose response of facial skin fibroblasts to glyoxal treatment as an inducer of premature senescence (research project, August 2012).
11. Henriette Jørgensen (Denmark): Donor age effects of serum on the wound healing ability of mesenchymal stem cells (research project; started: August 2012; completed: August 2013)).
12. Amalie Engstrom (Denmark): Effects of milk protein(s) on human facial skin fibroblasts (research project, started: September 2013; completed: May 2014)
13. Maja Fuhlendorff Jensen (Denmark): Testing the limits of nutritional stress tolerance of telomerase-immortalised human mesenchymal stem cells (research project, April-June 2015).
14. Piravina Sivanandam (Denmark): Testing the short term effects of stress hormone hydrocortisol on human skin fibroblasts (research project, April-June 2016).

Erasmus/Socrates and other international exchange student projects and visiting post-docs
1. Jean-Pierre Sibeijn (Belgium); Keratinocyte differentiation during ageing: a search for possible markers of keratinocyte ageing. (August 1992).
2. Diogo Sampaio e Castro (Spain); Attempts at optimising the culture medium for growth of human osteoblasts. (August 1994).
3. Isabel dos Santos Cardoso (Spain); Attempts to quantify EF-1a in cell cultures. (August 1995).
4. Regina Gonzalez Dosal (Spain); Effects of fish-, grape seed- and tomato extracts on cell proliferation and formation of 8-oxo-2´-deoxyguanosine in DNA in vitro. (June 2001).
5. Mari Sild (Estonia); Association of successful ageing with genomic maintenance and stress response: studies on WRN and HSP70 genes. (May 2005).
6. Ulrich Berge (Germany); Kinetin-indcued differentation of normal human keratinocytes undergoing ageing in vitro. (July 2005).
7. Juliane Behrens (Germany); Modulating differentiation and growth of immortalized keratinocytes by calcium, kinetin, curcumin, heat shock and sugars. (July 2006).
8. Joana M.T. Magalhaes (Portugal); Glucose-mediated modulation of ageing and differentiation of human bone marrow stem cells. (September 2006).
9. Malgorzata Wierzbicka (Poland); Glyoxal-induced accelerated ageing in hTERT-immobilized mesenchymal stem cells (March 2007).
10. Weiwei Luo (Singapore); Heat shock-mediated modulation of angiogenesis in human umbilical cord vascular and microvascular endothelial cells. (July 2007).
11. Ricardo Fernandes (Portugal); Modulation of wound healing by ageing human fibroblasts by heat shock and glyoxal. (August 2007).
12. Barbara Dymek (Poland); Testing the hormetic effects of curcumin on human fibroblasts (July 2008).
13. Clémentine Martres (France); Cellular stress responses with emphasis on autophagy (February 2011).
14. Marissa Priyanka Chatterjee (India-Sweden); Heat shock response of telomerase-immortalized human mesenchymal stem cells (May 2011).
15. Irene Martinex de Toda (Spain); Immediate stress responses in terms of transcriptional factor translocation in human cells (2012-2013).
16. Barbara Nardelli (Czech Republic); Testing the effects of natural and synthetic cytokinins on human facial skin fibroblasts (Sept-Nov 2013)
17. Ceren Gezer (Cyprus); PhD-student; Testing artichoke-component cynarin on oxidative stress response pathways in human cells (October 2013-April 2014)
18. Jennifer Mytych (Poland); MSc student; Testing the effects of silve- and gold-nano particles on human skin cells (September-December 2014)
19. Joana Alexandre Teixeira Lima (Portugal); BSc project; Induction of autophagy by fasting in human cells (Feb.-June 2015)
20. Indra Kumar, Gopi (India); M.Tech. student; Testing the effects of cortisol on immortalised bone marrow stem cells (March-June 2016).
21. Christine Reck (Germany): Testing the effects of Rosmarinic Acid on telomerase immortalised human bone marrow stem cells. (Sept 2016 to January 2017).

Post-docs
1. Dr. Phillipe Verbeke (France) Testing the anti-ageing effects of kinetin, and hormesis (1998-2000)
2. Dr. Yvonne Eskildsen-Helmond (Netherlands/Denmark): Stress kinases and hormesis (2000-2002)
3. Dr. Cristovao Lima (Portugal) – visiting post-doc (2008) testing the hormetic effects of curcumin, rosmarinic acid and other potential hormetin.