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Stig Purup

Seniorforsker

Profile photoStig Purup
Seniorforsker
Institut for Husdyrvidenskab - Molekylær ernæring og forplantning
Blichers Allé 20
P25, 3364
8830 Tjele
Danmark
E-mail: stig.purup@anis.au.dk
Mobil: +4529345955
Telefon: +4587157808
Web: http://pure.au.dk/portal/da/stig.purup@anis.au.dk
ORCHID: 0000-0003-0653-4751
Personlig information
Føde 6. december 1958 i Silkeborg

Profil

Mine hovedinteresser er cellebiologi og bioaktive komponenter.

Forskningen omfatter undersøgelser af indholdet af bioaktive komponenter i fodermidler og fødevarer og deres betydning for den ernærings- og sundhedsmæssige kvalitet. Der fokuseres på både naturligt forekommende stoffer, udefra kommende stoffer, og stoffer der er tilsat eller dannet i forbindelse med dyrkning, produktion, forarbejdning eller opbevaring. Betydningen af tilstedeværelsen og den fysiologiske virkning af de bioaktive komponenter for konsumenter og dyr klarlægges ved anvendelse af såvel in vitro celle-baserede modeller som dyremodeller.

Et særligt indsatsområde er bioaktive komponenter i naturlige biologiske væsker som f.eks. mælk, blod og plante- og vævsekstrakter. Aktuelle bioaktive komponenter af interesse er vækstfaktorer, hormoner, fedtsyrer, vitaminer, selenoproteiner, fytoøstrogener, mykotoxiner og polyacetylener.

Forskningen omfatter endvidere de fysiologiske forhold omkring dannelse af bioaktive komponenter i mælkekirtlen og deres udskillelse til mælken.

Den opnåede viden om bioaktive komponenter kan anvendes til udvikling af bedre metoder til forebyggelse og behandling af sygdomme hos mennesker og dyr, samt øget kvalitet og sikkerhed i fødevareproduktionen.

Education

1995: PhD, The Faculty of Health Science, University of Aarhus, Denmark

1988: Diploma in education in biology and mathematics, Aarhus Katedralskole, Denmark

1987: MSc. in biology and mathematics, University of Aarhus, Denmark

Further education

2010: PhD supervision course, Aarhus University

1993: Methods and Techniques in Lactation Physiology, National Institute of Animal Science

1991: Statistical analyses of animal experiments course, National Institute of Animal Science


Employment

2011-: Senior scientist MSK, Dept. of Animal Science, Aarhus University

2009-2011: Senior scientist MSK, Dept. of Animal Health and Bioscience, Aarhus University

1997-2009: Senior scientist, Danish Institute of Agricultural Sciences (DIAS), Research Centre Foulum

1992-1995: Scientist, DIAS, Research Centre Foulum

1988-1992: Scientist, The Royal Veterinary and Agricultural University, Copenhagen, Denmark

1987-1988: Teacher, Aarhus Kathedralskole, Denmark

1985: Scientific employee, Dept. Zoology and Zoophysiology, Aarhus University

Research

Focus on cell biology, endocrinology, physiology, gastroenterology and nutrition in animals and humans during health and disease. Experimental cell-based models and animal models for inflammatory diseases in weaned pigs. Special focus areas are: i) Cell-based screening for novel bioactive components in complex natural mixtures. ii) Effects of bioactive or nutritional components by use of cell-based models from human or animal tissues. Portfolio includes > 30 primary cells or cell lines of normal or transformed cells. iii) Impact of gut bacteria on human metabolism by in vitro screening technologies. iv) Impact of nutritional components on intestinal epithelial integrity, adipogenesis, insulin sensitivity and intracellular signaling proteins. iv) Wound healing in the GI-tract in relation to inflammatory diseases like IBD by use of animal models and cell-based assays. v) Bioengineered bacteria for targeted drug delivery to the GI-tract. vi) Somatic cells for production of transgenic farm animals.Author/co-author of 269 publications of which 106 are peer-reviewed scientific papers (25 since 2014). Web of Science 2639 citations, H-index 31. Google Scholar 3879 citations, H-index 35. m-index =1.3.

Research residences

2002-2003: Sabbatical at the biotechnology company TGR BioSciences Pty Ltd, Adelaide, Australia.

2001: Cornell University, Ithaca, New York, USA.

1998: Sabbatical at Dept. Animal Science, University of Vermont, Burlington, USA.

1993: Virginia Polytechnic Institute and State University, Depr. Animal Science, Virginia, USA.


Education and teaching

Education of PhD and MSc students. Teacher at Aarhus University (Nutritional Physiology, 2012-2016), University of Southern Denmark (Advanced Natural Product Chemistry XC-BIO3), and high school talents (AU (2005-) and ATU (2016-)). Member of AU Science and Technology recruitment committee, and AU Dept. Animal Science education committee. Member of the PhD committee at the Dept. Animal Science (2008-). Chair of 14 PhD assessment committees. Supervisor for PhD students (currently 2), post docs and MSc students. Examiner of MSc and official opponent at PhD defences.

Leadership, administration and research collaboration

Scientific and project managing experience, and experience in company-university interaction from working in a biotech company in Australia for 1 year, and from continued collaboration with companies nationally and internationally (see relations). Experience in fund raising, research management and coordination after receipt of more than 67 mio. DKK from Danish Research Councils, Innovation Fund Denmark, EU, and Directorate for Food, Fisheries and Agri Business as project leader or responsible for project WPs.
Collaborates with institutes, hospitals and companies national (AU; KU; SDU; DTU; AAU; AU-Hospital; Herlev Hospital; Hospital of Southern Jutland; DuPont Nutrition Biosciences; ARLA Foods Ingredients; Upfront Chromatography; Randers Regnskov; Green Gourmet A/S) and international (Mead Johnson Nutrition, Netherlands; DuPont Nutrition and Health, Finland; Nutreco Trouw Nutrition, Netherlands; TGR BioSciences, Adelaide, Australia; Univ. Reading, UK; Cornell Univ., USA; Michigan Univ., USA; Univ. Milan, Italy; Norwegian Inst. Bioeconomy Research, Norway; SLU, Sweden; Bejing Univ., China).
Reviewer for journals, among these British J Nutrition, American Journal of Physiololy, Journal of Dairy Research, Italian Journal of Animal Science, Journal of Dairy Science, Livestock Production Science, Domestic Animal Endocrinology, International Dairy Journal, Journal of Animal Science, Journal of Functional Foods, Journal of Agricultural Food Chemistry, and International Journal of Food Science and Technology.