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Steen Bønløkke Pedersen

More pronounced effect of acute exercise-induced increase in circulating inflammatory markers in obese compared to lean subjects.

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Objective: Exercise modulates the immune system and in young males acute exercise has been found associated with increased systemic level of infam-matory markers such as IL-6 and IL-8. In this study we investigated the impact of obesity on the exercise induced release of infammatory markers in circulation, and on gene expression on these infammatory marker in skeletal muscle (SM) and adipose tissue (AT) biopsies. Material and Methods: 15 lean males and females (BMI 22.4±2 kg/m2) and 16 obese males and females (BMI 31.6±3 kg/m2) exercised for 120 minutes by ergometer bicycling at moderate intensity (55-60% of maximal heart rate). Blood samples were obtained at baseline (T0), after 60 minutes of bicycling (T=60), after 120 minutes of bicycling (T=120), whereas biopsies from AT and SM were obtained at T0 and T120. Results: Divided into weight-status, plasma levels of IL-8 and TNFα were at T=120 significantly increased in the obese group (p<0.01) and not in the lean group. Moreover, at T=120 the increase in IL-6 was significantly higher in the obese as compared to the lean (all p<0.01). In SM, a significant increase in mRNA expression of IL-6, TNFα and IL-10 was observed (p<0.05-p<0.01). In AT, only the expression of IL-6 was increased significantly (p<0.01). Conclusion: These fndings show that acute exercise is associated with an increase in circulating level of infammatory markers. Moreover, the fndings suggest that the systemic infammatory response to acute exercise is different in lean and obese subjects
Sider (fra-til)106
StatusUdgivet - 2010

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