Institut for Biomedicin

Steen Bønløkke Pedersen

Estradiol acutely inhibits whole body lipid oxidation and attenuates lipolysis in subcutaneous adipose tissue: A randomized, placebo controlled study in post-menopausal women

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

CONTEXT: Estradiol promotes and maintains the female phenotype characterized by subcutaneous (sc) fat accumulation. There is evidence to suggest that this effect is due to increased anti-lipolytic α2A-adrenergic receptors, but whether this requires long-term exposure to estradiol or is an immediate effect is not clear. Objective: To study acute effects of a single dose (4 mg) of 17β-estradiol on regional and systemic lipolysis. Methods: 16 post-menopausal women (age 59 ± 5 years, weight 67 ± 10 kg, BMI 24.8 ± 2.9)) were studied in a cross-over design: 1) placebo, and 2) 4 mg estradiol. Basal and adrenaline stimulated regional lipolysis was assessed by microdialysis and substrate oxidation rates by indirect calorimetry. Tissue biopsies were obtained to assess LPL activity and mRNA expression of adrenergic, estrogen, cytokine and vascular reactivity receptors. Results: Acute estradiol stimulation significantly attenuated catecholamine stimulated lipolysis in femoral sc adipose tissue [interstitial glycerol concentration (µmol/l) ANOVA time vs. treatment interaction, p=0.01] and lipolysis in general in abdominal adipose tissue (ANOVA treatment alone, p
OriginalsprogEngelsk
TidsskriftEuropean Journal of Endocrinology
DOI
StatusE-pub ahead of print - 2012

Se relationer på Aarhus Universitet Citationsformater

ID: 48049790