Steen Bønløkke Pedersen

Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro

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Leptin is synthesized in adipocytes and acts primarily through central pathways suppressing appetite and increasing the metabolic rate in rodents as well as in humans. Recently leptin has also been suggested to have peripheral effects and be involved in insulin action. Since cytokines and chemokines may have effects on appetite regulation as well as on some of the obesity-related complications e.g. insulin resistance and cardiovascular disease, we investigated the effects of various cytokines and chemokines on leptin production in human adipose tissue fragments in vitro. Abdominal subcutaneous adipose tissue from healthy normal to overweight females was incubated for up to 48 h with the cytokines: tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) and the chemokine: interleukin-8 (IL-8). IL-1beta (50 ng/ml) and TNF-alpha (10 ng/ml) decreased leptin production by 30-50% (P
OriginalsprogEngelsk
TidsskriftMolecular and Cellular Endocrinology
Vol/bind190
Nummer1-2
Sider (fra-til)91-9
Antal sider9
ISSN0303-7207
StatusUdgivet - 2002

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