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Steen Bønløkke Pedersen

Effect of industrially produced trans fat on markers of endothelial dysfunction and systemic inflammation: evidence from a randomized trial in overweight women

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Nathalie T Bendsen
  • ,
  • Steen Stender
  • ,
  • Pal B Szecsi
  • ,
  • Steen B Pedersen
  • Samar Basu
  • ,
  • Lars Hellgren
  • ,
  • John W Newman
  • ,
  • Thomas M Larsen, Danmark
  • Steen Bendix Haugaard
  • ,
  • Arne Astrup
  • Medicinsk Endokrinologisk Afd., MEA, THG
Consumption of industrially produced trans fatty acids (IP-TFA) has been positively associated to systemic markers of low-grade inflammation and endothelial dysfunction in cross-sectional studies, but results from intervention studies are inconclusive. Therefore, we conducted a 16-week double-blind parallel intervention study with the objective to examine the effect of IP-TFA intake on biomarkers of inflammation, oxidative stress and endothelial dysfunction. Fifty-two healthy overweight postmenopausal women (49 completers) were randomized to receive either partially hydrogenated soybean oil (15.7 g/day IP-TFA) or control oil without IP-TFA. After 16 weeks, IP-TFA intake increased baseline-adjusted serum tumor necrosis factor (TNF)α by 12% (95% confidence interval (CI): 5-20; P=0.002) more in the IP-TFA group compared to controls. Plasma soluble TNF receptors 1 and 2 were also increased by IP-TFA [155 pg/ml (CI: 63-247); P
OriginalsprogEngelsk
TidsskriftJournal of Lipid Research
ISSN0022-2275
DOI
StatusUdgivet - 27 jul. 2011

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