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Steen Bønløkke Pedersen

Adipose tissue, estradiol levels, and bone health in obese men with metabolic syndrome

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Marie Juul Ornstrup
  • Thomas Nordstrøm Kjær, T Kjær, Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C, Denmark., Danmark
  • Torben Harsløf
  • Hans Stødkilde-Jørgensen, H Stødkilde-Jørgensen, The MR Research Center, Aarhus University Hospital, Aarhus N, Denmark., Danmark
  • David M Hougaard, D Hougaard, Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark.
  • ,
  • Arieh Cohen, A Cohen, Department of Clinical Biochemistry, Statens Serum Institut, Copenhagen, Denmark.
  • ,
  • Steen Bønløkke Pedersen
  • Bente Lomholt Langdahl

Objective: Visceral adipose tissue (VAT) is associated with increased risk of metabolic syndrome. Recent studies suggest that VAT negatively affects bone. However, metabolic syndrome has also been associated with higher estradiol (E) levels, which is bone protective. We therefore investigated the impact of VAT and E levels on bone density, structural parameters, and strength estimates. Design: A cross-sectional study of 72 obese men with metabolic syndrome. Methods: Bone parameters were assessed by DXA, QCT, and HRpQCT at lumbar spine, proximal femur, radius, and tibia. VAT volume was measured by MRI and sexual hormones were measured in blood samples. Results: Men with high VAT had lower bone density at the hip (p<0.05), lower cortical thickness and higher buckling ratio at femoral neck (p=0.008 and p=0.02), compared to men with low VAT, despite similar body weight and BMI. Generally, E levels were low (median 43 pmol/l), and men with E below median had reduced bone density at lumbar spine (p=0.04), and impaired structural parameters at radius and tibia, compared to men with E above median. At the hip, VAT volume and E levels independently and additively affected bone density, and 50% of men with high VAT and low E levels had osteopenia with significantly lower T-score at femoral neck (p=0.004). Conclusions: High VAT and low E negatively affect bone in obese men with metabolic syndrome. VAT and E independently and additively affect bone density at the hip, revealing an unexpected high prevalence of osteopenia in middle-aged men with metabolic syndrome.

TidsskriftEuropean Journal of Endocrinology
Vol/bind 172
Sider (fra-til)205-216
StatusUdgivet - 1 feb. 2015

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