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Steen Bønløkke Pedersen

Acute exercise increases circulating inflammatory markers in overweight and obese compared with lean subjects

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The primary aim of the present study was to investigate if overweight and obese compared to lean individuals displayed differences in levels of inflammatory markers in circulation, skeletal muscle (SM) and adipose tissue (AT) after acute exercise. Fifteen lean (BMI: 22.4 ± 2 kg/m(2)) and 16 overweight or obese (BMI 31.8 ± 3 kg/m(2)) individuals were included in the study. They completed 120 min of ergometer bicycling at 55-60 % of maximal heart rate. Blood samples were obtained at baseline (T = 0), after 60 (T = 60) and 120 min of exercise (T = 120), and analyzed using an ELISA method. SM and AT biopsies were obtained at T0 and T120, and mRNA expression was investigated using a Real-time RT-PCR method. Circulating IL-6, TNF-α, IL-8, and IL-15 all increased at T = 120 min (p 
OriginalsprogEngelsk
TidsskriftEuropean Journal of Applied Physiology
Vol/bind113
Nummer6
Sider (fra-til)1635-42
Antal sider8
ISSN1439-6319
DOI
StatusUdgivet - 2013

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