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Søren Vrønning Hoffmann

Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms

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  • Malgorzata A. Smialek, Open Univ, Open University - UK, Dept Phys Sci
  • ,
  • Sylwia Ptasinska, University of Notre Dame, Danmark
  • Jason Gow, Open Univ, Open University - UK, Dept Phys Sci, Danmark
  • Soren Vronning Hoffmann
  • Nigel J. Mason, Open Univ, Open University - UK, Dept Phys Sci

Irradiations of plasmid DNA by both X-rays and UV light in the presence and absence of compounds containing platinum and bromine atoms were performed in order to asses the sensitization potential of these compounds. Plasmid DNA pBR322 was incubated with platinum (II) bromide, hydrogen hexabromoplatinate (IV), hydrogen hexahydroxyplatinate (IV) and sodium hexahydroxyplatinate (IV). Incubation was followed by X-ray or UV irradiations. It was found that amongst the sensitizers tested, during irradiations carried out in the presence of platinum (II) bromide, the highest levels of double strand breaks formation upon X-ray treatment were recorded. In contrast much less damage was induced by UV light. Data presented here suggests that this compound may be a promising radiosensitizer for cancer treatment.

OriginalsprogEngelsk
Artikelnummer121
TidsskriftThe European Physical Journal D: Atomic, Molecular, Optical and Plasma Physics
Vol/bind69
Nummer5
Antal sider6
ISSN1434-6060
DOI
StatusUdgivet - 5 maj 2015

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