Sisse Helle Njor

The optimal cut-off value in fit-based colorectal cancer screening: An observational study

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Standard

The optimal cut-off value in fit-based colorectal cancer screening : An observational study. / Njor, Sisse Helle; Andersen, Berit; Friis-Hansen, Lennart; Haas, Niels Daniel Hansen de; Linnemann, Dorte; Nørgaard, Henrik; Roikjær, Ole; Søndergaard, Bo; Rasmussen, Morten.

I: Cancer Medicine, Bind 10, Nr. 5, 03.2021, s. 1872-1879.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Njor, SH, Andersen, B, Friis-Hansen, L, Haas, NDHD, Linnemann, D, Nørgaard, H, Roikjær, O, Søndergaard, B & Rasmussen, M 2021, 'The optimal cut-off value in fit-based colorectal cancer screening: An observational study', Cancer Medicine, bind 10, nr. 5, s. 1872-1879. https://doi.org/10.1002/cam4.3761

APA

Njor, S. H., Andersen, B., Friis-Hansen, L., Haas, N. D. H. D., Linnemann, D., Nørgaard, H., Roikjær, O., Søndergaard, B., & Rasmussen, M. (2021). The optimal cut-off value in fit-based colorectal cancer screening: An observational study. Cancer Medicine, 10(5), 1872-1879. https://doi.org/10.1002/cam4.3761

CBE

Njor SH, Andersen B, Friis-Hansen L, Haas NDHD, Linnemann D, Nørgaard H, Roikjær O, Søndergaard B, Rasmussen M. 2021. The optimal cut-off value in fit-based colorectal cancer screening: An observational study. Cancer Medicine. 10(5):1872-1879. https://doi.org/10.1002/cam4.3761

MLA

Vancouver

Njor SH, Andersen B, Friis-Hansen L, Haas NDHD, Linnemann D, Nørgaard H o.a. The optimal cut-off value in fit-based colorectal cancer screening: An observational study. Cancer Medicine. 2021 mar;10(5):1872-1879. https://doi.org/10.1002/cam4.3761

Author

Njor, Sisse Helle ; Andersen, Berit ; Friis-Hansen, Lennart ; Haas, Niels Daniel Hansen de ; Linnemann, Dorte ; Nørgaard, Henrik ; Roikjær, Ole ; Søndergaard, Bo ; Rasmussen, Morten. / The optimal cut-off value in fit-based colorectal cancer screening : An observational study. I: Cancer Medicine. 2021 ; Bind 10, Nr. 5. s. 1872-1879.

Bibtex

@article{c7f379dcdeb54121ae117be4f1eb474f,
title = "The optimal cut-off value in fit-based colorectal cancer screening: An observational study",
abstract = "Background:Colorectal cancer (CRC) screening programs using fecal immunochemical test (FIT) have to choose a cut-off value to decide which citizens to recallfor colonoscopy. The evidence on the optimal cut-off value is sparse and based on studies with a low number of cancer cases.Methods: This observational study used data from the Danish Colorectal CancerScreening Database. Sensitivity and specificity were estimated for various cut-offvalues based on a large number of cancers. Traditionally optimal cut-off values are found by weighting sensitivity and specificity equally. As this might result in too many unnecessary colonoscopies we also provide optimal cut-off values for different weighting of sensitivity and specificity/number of needed colonoscopies to detect one cancer.Results:Weighting sensitivity and specificity equally gives an optimal cut-off value of 45 ng Hb/ml. This, however, means making 24 colonoscopies to detect one cancer. Weighting sensitivity lower and for example, aiming at making about 16 colonoscopies to detect one cancer, gives an optimal cut-off value of 125 ng Hb/ml.Conclusions: The optimal cut-off value in an FIT population-based screening program is 45 ng Hb/ml, when as traditionally sensitivity and specificity are weighted equally. If, however, 24 colonoscopies needed to detect one cancer is too huge a burden on the health care system and the participants, 80, 125, 175, and 350 ng Hb/ml are optimal cut-off values when only 19/16/14/10 colonoscopies are accepted to find one cancer.",
keywords = "capacity building, colorectal neoplasms, mass screening, sensitivity, specificity",
author = "Njor, {Sisse Helle} and Berit Andersen and Lennart Friis-Hansen and Haas, {Niels Daniel Hansen de} and Dorte Linnemann and Henrik N{\o}rgaard and Ole Roikj{\ae}r and Bo S{\o}ndergaard and Morten Rasmussen",
year = "2021",
month = mar,
doi = "10.1002/cam4.3761",
language = "English",
volume = "10",
pages = "1872--1879",
journal = "Cancer Medicine",
issn = "2045-7634",
publisher = "JohnWiley & Sons Ltd.",
number = "5",

}

RIS

TY - JOUR

T1 - The optimal cut-off value in fit-based colorectal cancer screening

T2 - An observational study

AU - Njor, Sisse Helle

AU - Andersen, Berit

AU - Friis-Hansen, Lennart

AU - Haas, Niels Daniel Hansen de

AU - Linnemann, Dorte

AU - Nørgaard, Henrik

AU - Roikjær, Ole

AU - Søndergaard, Bo

AU - Rasmussen, Morten

PY - 2021/3

Y1 - 2021/3

N2 - Background:Colorectal cancer (CRC) screening programs using fecal immunochemical test (FIT) have to choose a cut-off value to decide which citizens to recallfor colonoscopy. The evidence on the optimal cut-off value is sparse and based on studies with a low number of cancer cases.Methods: This observational study used data from the Danish Colorectal CancerScreening Database. Sensitivity and specificity were estimated for various cut-offvalues based on a large number of cancers. Traditionally optimal cut-off values are found by weighting sensitivity and specificity equally. As this might result in too many unnecessary colonoscopies we also provide optimal cut-off values for different weighting of sensitivity and specificity/number of needed colonoscopies to detect one cancer.Results:Weighting sensitivity and specificity equally gives an optimal cut-off value of 45 ng Hb/ml. This, however, means making 24 colonoscopies to detect one cancer. Weighting sensitivity lower and for example, aiming at making about 16 colonoscopies to detect one cancer, gives an optimal cut-off value of 125 ng Hb/ml.Conclusions: The optimal cut-off value in an FIT population-based screening program is 45 ng Hb/ml, when as traditionally sensitivity and specificity are weighted equally. If, however, 24 colonoscopies needed to detect one cancer is too huge a burden on the health care system and the participants, 80, 125, 175, and 350 ng Hb/ml are optimal cut-off values when only 19/16/14/10 colonoscopies are accepted to find one cancer.

AB - Background:Colorectal cancer (CRC) screening programs using fecal immunochemical test (FIT) have to choose a cut-off value to decide which citizens to recallfor colonoscopy. The evidence on the optimal cut-off value is sparse and based on studies with a low number of cancer cases.Methods: This observational study used data from the Danish Colorectal CancerScreening Database. Sensitivity and specificity were estimated for various cut-offvalues based on a large number of cancers. Traditionally optimal cut-off values are found by weighting sensitivity and specificity equally. As this might result in too many unnecessary colonoscopies we also provide optimal cut-off values for different weighting of sensitivity and specificity/number of needed colonoscopies to detect one cancer.Results:Weighting sensitivity and specificity equally gives an optimal cut-off value of 45 ng Hb/ml. This, however, means making 24 colonoscopies to detect one cancer. Weighting sensitivity lower and for example, aiming at making about 16 colonoscopies to detect one cancer, gives an optimal cut-off value of 125 ng Hb/ml.Conclusions: The optimal cut-off value in an FIT population-based screening program is 45 ng Hb/ml, when as traditionally sensitivity and specificity are weighted equally. If, however, 24 colonoscopies needed to detect one cancer is too huge a burden on the health care system and the participants, 80, 125, 175, and 350 ng Hb/ml are optimal cut-off values when only 19/16/14/10 colonoscopies are accepted to find one cancer.

KW - capacity building

KW - colorectal neoplasms

KW - mass screening

KW - sensitivity

KW - specificity

UR - http://www.scopus.com/inward/record.url?scp=85100330431&partnerID=8YFLogxK

U2 - 10.1002/cam4.3761

DO - 10.1002/cam4.3761

M3 - Journal article

C2 - 33534955

VL - 10

SP - 1872

EP - 1879

JO - Cancer Medicine

JF - Cancer Medicine

SN - 2045-7634

IS - 5

ER -