Sisse Helle Njor

Potential for prevention: A cohort study of colonoscopies and removal of adenomas in a FIT-based colorectal cancer screening programme

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Potential for prevention : A cohort study of colonoscopies and removal of adenomas in a FIT-based colorectal cancer screening programme. / Larsen, Mette Bach; Njor, Sisse Helle; Jensen, Thomas Møller; Ingeholm, Peter; Andersen, Berit.

I: Scandinavian Journal of Gastroenterology, Bind 54, Nr. 8, 08.2019, s. 1008-1014.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Larsen, Mette Bach ; Njor, Sisse Helle ; Jensen, Thomas Møller ; Ingeholm, Peter ; Andersen, Berit. / Potential for prevention : A cohort study of colonoscopies and removal of adenomas in a FIT-based colorectal cancer screening programme. I: Scandinavian Journal of Gastroenterology. 2019 ; Bind 54, Nr. 8. s. 1008-1014.

Bibtex

@article{80d85b0ca33c4ee69f5e3b074ad95f5b,
title = "Potential for prevention: A cohort study of colonoscopies and removal of adenomas in a FIT-based colorectal cancer screening programme",
abstract = "Introduction: Evidence suggests that colorectal cancer (CRC) screening using guaiac faecal occult blood tests (gFOBT) reduces the CRC burden by facilitating timely removal of adenomas. Yet, the faecal immunochemical test (FIT) is being implemented in many countries. The aim of this study was to analyse the risk of having adenomas detected when invited for FIT-based screening as compared to those not yet invited. Material and Methods: The study was designed as a register-based retrospective cohort study. The potential for prevention was estimated as number of individuals who had no adenomas, non-advanced adenomas, and advanced adenomas detected per 1000 invited/not yet invited individuals and the relative risk (RR) of each of the three outcomes. Results: A total of 1,359,340 individuals were included, 29.6% of whom had been invited and 70.4% had not yet been invited to participate in CRC screening. Compared with the not yet invited population, the invited group had a RR of no adenomas of 2.28 (2.22–2.34) and a RR of advanced adenomas of 7.41 (6.93–7.91). The RR of colonoscopy was 2.93 (2.87–2.99) for the invited population compared with the not yet invited population. Conclusion: The RR of having a colonoscopy was three times higher among those invited compared to those not yet invited for CRC screening and twice as often those who had been invited compared to those not yet invited had no adenomas detected. Still, the risk of advanced adenomas was more than seven times higher among the invited population, indicating that the screening programme holds great potential for reducing the CRC burden. Abbreviations: CI: Confidence interval; CRC: Colorectal cancer; FIT: Faecal immunochemical test; ICD: International Classification of Disease; RR: Relative risk.",
keywords = "adenoma, colorectal neoplasms, faeces, mass screening, Primary prevention, OCCULT BLOOD-TESTS, HEMOGLOBIN, DIAGNOSTIC COLONOSCOPY, PERFORMANCE, RISK, TRENDS, ETHICAL-ISSUES, FECAL IMMUNOCHEMICAL TESTS, COMPLICATIONS, PARTICIPANTS",
author = "Larsen, {Mette Bach} and Njor, {Sisse Helle} and Jensen, {Thomas M{\o}ller} and Peter Ingeholm and Berit Andersen",
year = "2019",
month = aug,
doi = "10.1080/00365521.2019.1647282",
language = "English",
volume = "54",
pages = "1008--1014",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Taylor & Francis ",
number = "8",

}

RIS

TY - JOUR

T1 - Potential for prevention

T2 - A cohort study of colonoscopies and removal of adenomas in a FIT-based colorectal cancer screening programme

AU - Larsen, Mette Bach

AU - Njor, Sisse Helle

AU - Jensen, Thomas Møller

AU - Ingeholm, Peter

AU - Andersen, Berit

PY - 2019/8

Y1 - 2019/8

N2 - Introduction: Evidence suggests that colorectal cancer (CRC) screening using guaiac faecal occult blood tests (gFOBT) reduces the CRC burden by facilitating timely removal of adenomas. Yet, the faecal immunochemical test (FIT) is being implemented in many countries. The aim of this study was to analyse the risk of having adenomas detected when invited for FIT-based screening as compared to those not yet invited. Material and Methods: The study was designed as a register-based retrospective cohort study. The potential for prevention was estimated as number of individuals who had no adenomas, non-advanced adenomas, and advanced adenomas detected per 1000 invited/not yet invited individuals and the relative risk (RR) of each of the three outcomes. Results: A total of 1,359,340 individuals were included, 29.6% of whom had been invited and 70.4% had not yet been invited to participate in CRC screening. Compared with the not yet invited population, the invited group had a RR of no adenomas of 2.28 (2.22–2.34) and a RR of advanced adenomas of 7.41 (6.93–7.91). The RR of colonoscopy was 2.93 (2.87–2.99) for the invited population compared with the not yet invited population. Conclusion: The RR of having a colonoscopy was three times higher among those invited compared to those not yet invited for CRC screening and twice as often those who had been invited compared to those not yet invited had no adenomas detected. Still, the risk of advanced adenomas was more than seven times higher among the invited population, indicating that the screening programme holds great potential for reducing the CRC burden. Abbreviations: CI: Confidence interval; CRC: Colorectal cancer; FIT: Faecal immunochemical test; ICD: International Classification of Disease; RR: Relative risk.

AB - Introduction: Evidence suggests that colorectal cancer (CRC) screening using guaiac faecal occult blood tests (gFOBT) reduces the CRC burden by facilitating timely removal of adenomas. Yet, the faecal immunochemical test (FIT) is being implemented in many countries. The aim of this study was to analyse the risk of having adenomas detected when invited for FIT-based screening as compared to those not yet invited. Material and Methods: The study was designed as a register-based retrospective cohort study. The potential for prevention was estimated as number of individuals who had no adenomas, non-advanced adenomas, and advanced adenomas detected per 1000 invited/not yet invited individuals and the relative risk (RR) of each of the three outcomes. Results: A total of 1,359,340 individuals were included, 29.6% of whom had been invited and 70.4% had not yet been invited to participate in CRC screening. Compared with the not yet invited population, the invited group had a RR of no adenomas of 2.28 (2.22–2.34) and a RR of advanced adenomas of 7.41 (6.93–7.91). The RR of colonoscopy was 2.93 (2.87–2.99) for the invited population compared with the not yet invited population. Conclusion: The RR of having a colonoscopy was three times higher among those invited compared to those not yet invited for CRC screening and twice as often those who had been invited compared to those not yet invited had no adenomas detected. Still, the risk of advanced adenomas was more than seven times higher among the invited population, indicating that the screening programme holds great potential for reducing the CRC burden. Abbreviations: CI: Confidence interval; CRC: Colorectal cancer; FIT: Faecal immunochemical test; ICD: International Classification of Disease; RR: Relative risk.

KW - adenoma

KW - colorectal neoplasms

KW - faeces

KW - mass screening

KW - Primary prevention

KW - OCCULT BLOOD-TESTS

KW - HEMOGLOBIN

KW - DIAGNOSTIC COLONOSCOPY

KW - PERFORMANCE

KW - RISK

KW - TRENDS

KW - ETHICAL-ISSUES

KW - FECAL IMMUNOCHEMICAL TESTS

KW - COMPLICATIONS

KW - PARTICIPANTS

UR - http://www.scopus.com/inward/record.url?scp=85070791735&partnerID=8YFLogxK

U2 - 10.1080/00365521.2019.1647282

DO - 10.1080/00365521.2019.1647282

M3 - Journal article

C2 - 31397598

AN - SCOPUS:85070791735

VL - 54

SP - 1008

EP - 1014

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 8

ER -