Signe Hjuler Boudigaard

A follow-up study of occupational styrene exposure and risk of autoimmune rheumatic diseases

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A follow-up study of occupational styrene exposure and risk of autoimmune rheumatic diseases. / Hjuler Boudigaard, Signe; Stokholm, Zara Ann; Vestergaard, Jesper Medom; Mohr, Mette Skovgaard; Søndergaard, Klaus; Torén, Kjell; Schlünssen, Vivi; Kolstad, Henrik A.

I: Occupational and Environmental Medicine, Bind 77, Nr. 2, 106018, 02.2020, s. 64-69.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{7bd987937f6441d68c7f510a8efd71ef,
title = "A follow-up study of occupational styrene exposure and risk of autoimmune rheumatic diseases",
abstract = "OBJECTIVES: Increased risk has been suggested for autoimmune rheumatic diseases following solvent exposure. The evidence for specific solvents is limited, and little is known about exposure-response relations. Styrene is an aromatic, organic solvent and the objective of this study was to analyse the association between occupational styrene exposure and autoimmune rheumatic diseases in men and women.METHODS: We followed 72 212 styrene-exposed workers of the Danish reinforced plastics industry from 1979 to 2012. We modelled full work history of styrene exposure from employment history, survey data and historical styrene exposure measurements. We identified cases in the national patient registry and investigated gender-specific exposure-response relations by cumulative styrene exposure for different exposure time windows adjusting for age, calendar year and educational level.RESULTS: During 1 515 126 person-years of follow-up, we identified 718 cases of an autoimmune rheumatic disease, of which 73% were rheumatoid arthritis. When adjusting for potential confounders and comparing the highest with the lowest styrene exposure tertile, we observed a statistically non-significantly increased risk of systemic sclerosis among women (incidence rate ratio (IRR)=2.50; 95% CI 0.50 to 12.50) and men (IRR=1.86; 95 % CI 0.50 to 7.00), based on 9 and 22 cases, respectively. Results were inconsistent for the other autoimmune rheumatic diseases examined.CONCLUSION: This study suggests an association between occupational styrene exposure and systemic sclerosis in men as well as in women but based on few cases. This is a new finding and has to be replicated before conclusions can be drawn.",
keywords = "autoimmune diseases, connective tissue diseases, occupational exposure, solvents, systemic scleroderma",
author = "{Hjuler Boudigaard}, Signe and Stokholm, {Zara Ann} and Vestergaard, {Jesper Medom} and Mohr, {Mette Skovgaard} and Klaus S{\o}ndergaard and Kjell Tor{\'e}n and Vivi Schl{\"u}nssen and Kolstad, {Henrik A}",
note = "{\textcopyright} Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2020",
month = feb,
doi = "10.1136/oemed-2019-106018",
language = "English",
volume = "77",
pages = "64--69",
journal = "Occupational and Environmental Medicine",
issn = "1351-0711",
publisher = "B M J Group",
number = "2",

}

RIS

TY - JOUR

T1 - A follow-up study of occupational styrene exposure and risk of autoimmune rheumatic diseases

AU - Hjuler Boudigaard, Signe

AU - Stokholm, Zara Ann

AU - Vestergaard, Jesper Medom

AU - Mohr, Mette Skovgaard

AU - Søndergaard, Klaus

AU - Torén, Kjell

AU - Schlünssen, Vivi

AU - Kolstad, Henrik A

N1 - © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2020/2

Y1 - 2020/2

N2 - OBJECTIVES: Increased risk has been suggested for autoimmune rheumatic diseases following solvent exposure. The evidence for specific solvents is limited, and little is known about exposure-response relations. Styrene is an aromatic, organic solvent and the objective of this study was to analyse the association between occupational styrene exposure and autoimmune rheumatic diseases in men and women.METHODS: We followed 72 212 styrene-exposed workers of the Danish reinforced plastics industry from 1979 to 2012. We modelled full work history of styrene exposure from employment history, survey data and historical styrene exposure measurements. We identified cases in the national patient registry and investigated gender-specific exposure-response relations by cumulative styrene exposure for different exposure time windows adjusting for age, calendar year and educational level.RESULTS: During 1 515 126 person-years of follow-up, we identified 718 cases of an autoimmune rheumatic disease, of which 73% were rheumatoid arthritis. When adjusting for potential confounders and comparing the highest with the lowest styrene exposure tertile, we observed a statistically non-significantly increased risk of systemic sclerosis among women (incidence rate ratio (IRR)=2.50; 95% CI 0.50 to 12.50) and men (IRR=1.86; 95 % CI 0.50 to 7.00), based on 9 and 22 cases, respectively. Results were inconsistent for the other autoimmune rheumatic diseases examined.CONCLUSION: This study suggests an association between occupational styrene exposure and systemic sclerosis in men as well as in women but based on few cases. This is a new finding and has to be replicated before conclusions can be drawn.

AB - OBJECTIVES: Increased risk has been suggested for autoimmune rheumatic diseases following solvent exposure. The evidence for specific solvents is limited, and little is known about exposure-response relations. Styrene is an aromatic, organic solvent and the objective of this study was to analyse the association between occupational styrene exposure and autoimmune rheumatic diseases in men and women.METHODS: We followed 72 212 styrene-exposed workers of the Danish reinforced plastics industry from 1979 to 2012. We modelled full work history of styrene exposure from employment history, survey data and historical styrene exposure measurements. We identified cases in the national patient registry and investigated gender-specific exposure-response relations by cumulative styrene exposure for different exposure time windows adjusting for age, calendar year and educational level.RESULTS: During 1 515 126 person-years of follow-up, we identified 718 cases of an autoimmune rheumatic disease, of which 73% were rheumatoid arthritis. When adjusting for potential confounders and comparing the highest with the lowest styrene exposure tertile, we observed a statistically non-significantly increased risk of systemic sclerosis among women (incidence rate ratio (IRR)=2.50; 95% CI 0.50 to 12.50) and men (IRR=1.86; 95 % CI 0.50 to 7.00), based on 9 and 22 cases, respectively. Results were inconsistent for the other autoimmune rheumatic diseases examined.CONCLUSION: This study suggests an association between occupational styrene exposure and systemic sclerosis in men as well as in women but based on few cases. This is a new finding and has to be replicated before conclusions can be drawn.

KW - autoimmune diseases

KW - connective tissue diseases

KW - occupational exposure

KW - solvents

KW - systemic scleroderma

U2 - 10.1136/oemed-2019-106018

DO - 10.1136/oemed-2019-106018

M3 - Journal article

C2 - 31848232

VL - 77

SP - 64

EP - 69

JO - Occupational and Environmental Medicine

JF - Occupational and Environmental Medicine

SN - 1351-0711

IS - 2

M1 - 106018

ER -