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Sergey Fedosov

Access to organometallic arylcobaltcorrins through radical synthesis: 4-Ethylphenylcobalamin, a potential "antivitamin B"

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • M. Ruetz, University of Innsbruck
  • ,
  • B. Kräutler, University of Innsbruck
  • ,
  • S. Fedosov
  • K. Gruber, University of Graz
  • ,
  • C. Gherasim, University of Michigan
  • ,
  • R. Banerjee, University of Michigan, USA
Locked B: 4-Ethylphenylcobalamin, a novel organometallic arylcobalamin, has been synthesized in a radical reaction. This vitamin B antimetabolite features a strong Co-C bond, and represents a "locked" form of vitamin B (see picture). It may be used in animal studies to induce functional vitamin B deficiency artificially to help clarify still controversial issues related to the pathophysiology of vitamin B deficiency.
OriginalsprogEngelsk
TidsskriftAngewandte Chemie International Edition
Vol/bind52
Nummer9
Sider (fra-til)2606-2610
Antal sider5
ISSN1433-7851
DOI
StatusUdgivet - 25 feb. 2013

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