Institut for Biomedicin

Rune Nguyen Rasmussen

Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice

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Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice. / Rasmussen, Rune; Nicholas, Eric; Petersen, Nicolas Caesar; Dietz, Andrea Grostøl; Xu, Qiwu; Sun, Qian; Nedergaard, Maiken.

I: Cell Reports, Bind 28, Nr. 5, 30.07.2019, s. 1182-1194.e4.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Rasmussen, R, Nicholas, E, Petersen, NC, Dietz, AG, Xu, Q, Sun, Q & Nedergaard, M 2019, 'Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice', Cell Reports, bind 28, nr. 5, s. 1182-1194.e4. https://doi.org/10.1016/j.celrep.2019.06.082

APA

Rasmussen, R., Nicholas, E., Petersen, N. C., Dietz, A. G., Xu, Q., Sun, Q., & Nedergaard, M. (2019). Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice. Cell Reports, 28(5), 1182-1194.e4. https://doi.org/10.1016/j.celrep.2019.06.082

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Author

Rasmussen, Rune ; Nicholas, Eric ; Petersen, Nicolas Caesar ; Dietz, Andrea Grostøl ; Xu, Qiwu ; Sun, Qian ; Nedergaard, Maiken. / Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice. I: Cell Reports. 2019 ; Bind 28, Nr. 5. s. 1182-1194.e4.

Bibtex

@article{fa3cb067971e4f17af29f1b7d316cb54,
title = "Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice",
abstract = "Brain state fluctuations modulate sensory processing, but the factors governing state-dependent neural activity remain unclear. Here, we tracked the dynamics of cortical extracellular K+ concentrations ([K+]o) during awake state transitions and manipulated [K+]o in slices, during visual processing, and during skilled motor execution. When mice transitioned from quiescence to locomotion, [K+]o increased by 0.6-1.0 mM in all cortical areas analyzed, and this preceded locomotion by 1 s. Emulating the state-dependent [K+]o increase in cortical slices caused neuronal depolarization and enhanced input-output transformation. In vivo, locomotion increased the gain of visually evoked responses in layer 2/3 of visual cortex; this effect was recreated by imposing a [K+]o increase. Elevating [K+]o in the motor cortex increased movement-induced neuronal spiking in layer 5 and improved motor performance. Thus, [K+]o increases in a cortex-wide state-dependent manner, and this [K+]o increase affects both sensory and motor processing through the dynamic modulation of neural activity.",
author = "Rune Rasmussen and Eric Nicholas and Petersen, {Nicolas Caesar} and Dietz, {Andrea Grost{\o}l} and Qiwu Xu and Qian Sun and Maiken Nedergaard",
note = "Copyright {\textcopyright} 2019 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = jul,
day = "30",
doi = "10.1016/j.celrep.2019.06.082",
language = "English",
volume = "28",
pages = "1182--1194.e4",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "5",

}

RIS

TY - JOUR

T1 - Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice

AU - Rasmussen, Rune

AU - Nicholas, Eric

AU - Petersen, Nicolas Caesar

AU - Dietz, Andrea Grostøl

AU - Xu, Qiwu

AU - Sun, Qian

AU - Nedergaard, Maiken

N1 - Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2019/7/30

Y1 - 2019/7/30

N2 - Brain state fluctuations modulate sensory processing, but the factors governing state-dependent neural activity remain unclear. Here, we tracked the dynamics of cortical extracellular K+ concentrations ([K+]o) during awake state transitions and manipulated [K+]o in slices, during visual processing, and during skilled motor execution. When mice transitioned from quiescence to locomotion, [K+]o increased by 0.6-1.0 mM in all cortical areas analyzed, and this preceded locomotion by 1 s. Emulating the state-dependent [K+]o increase in cortical slices caused neuronal depolarization and enhanced input-output transformation. In vivo, locomotion increased the gain of visually evoked responses in layer 2/3 of visual cortex; this effect was recreated by imposing a [K+]o increase. Elevating [K+]o in the motor cortex increased movement-induced neuronal spiking in layer 5 and improved motor performance. Thus, [K+]o increases in a cortex-wide state-dependent manner, and this [K+]o increase affects both sensory and motor processing through the dynamic modulation of neural activity.

AB - Brain state fluctuations modulate sensory processing, but the factors governing state-dependent neural activity remain unclear. Here, we tracked the dynamics of cortical extracellular K+ concentrations ([K+]o) during awake state transitions and manipulated [K+]o in slices, during visual processing, and during skilled motor execution. When mice transitioned from quiescence to locomotion, [K+]o increased by 0.6-1.0 mM in all cortical areas analyzed, and this preceded locomotion by 1 s. Emulating the state-dependent [K+]o increase in cortical slices caused neuronal depolarization and enhanced input-output transformation. In vivo, locomotion increased the gain of visually evoked responses in layer 2/3 of visual cortex; this effect was recreated by imposing a [K+]o increase. Elevating [K+]o in the motor cortex increased movement-induced neuronal spiking in layer 5 and improved motor performance. Thus, [K+]o increases in a cortex-wide state-dependent manner, and this [K+]o increase affects both sensory and motor processing through the dynamic modulation of neural activity.

U2 - 10.1016/j.celrep.2019.06.082

DO - 10.1016/j.celrep.2019.06.082

M3 - Journal article

C2 - 31365863

VL - 28

SP - 1182-1194.e4

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 5

ER -