Institut for Biomedicin

Rune Nguyen Rasmussen

Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Rune Rasmussen
  • Eric Nicholas, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, USA.
  • ,
  • Nicolas Caesar Petersen, Københavns Universitet
  • ,
  • Andrea Grostøl Dietz, Københavns Universitet
  • ,
  • Qiwu Xu, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, USA.
  • ,
  • Qian Sun, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, New York 14642, USA.
  • ,
  • Maiken Nedergaard, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA; Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen N, Denmark. Electronic address: maiken_nedergaard@urmc.rochester.edu.

Brain state fluctuations modulate sensory processing, but the factors governing state-dependent neural activity remain unclear. Here, we tracked the dynamics of cortical extracellular K+ concentrations ([K+]o) during awake state transitions and manipulated [K+]o in slices, during visual processing, and during skilled motor execution. When mice transitioned from quiescence to locomotion, [K+]o increased by 0.6-1.0 mM in all cortical areas analyzed, and this preceded locomotion by 1 s. Emulating the state-dependent [K+]o increase in cortical slices caused neuronal depolarization and enhanced input-output transformation. In vivo, locomotion increased the gain of visually evoked responses in layer 2/3 of visual cortex; this effect was recreated by imposing a [K+]o increase. Elevating [K+]o in the motor cortex increased movement-induced neuronal spiking in layer 5 and improved motor performance. Thus, [K+]o increases in a cortex-wide state-dependent manner, and this [K+]o increase affects both sensory and motor processing through the dynamic modulation of neural activity.

OriginalsprogEngelsk
TidsskriftCell Reports
Vol/bind28
Nummer5
Sider (fra-til)1182-1194.e4
ISSN2211-1247
DOI
StatusUdgivet - 30 jul. 2019
Eksternt udgivetJa

Bibliografisk note

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

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