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Rune Hartmann

Professor

Personal details

3 children, born 2008, 2010 and 2012
Paternity leave : 2009, 2010, and 2013 (8 weeks each time)
ORCID: 0000-0003-1159-066X

Educations

2001-09-05: PhD in Molecular Biology, The Faculty of Natural Science, Aarhus University.
1997: MSc in Biology, The Faculty of Natural Sciences, Aarhus University.

Appointments

2018-present: Professor, Department of Molecular Biology and Genetics, Aarhus University.
2004-2018:    Associate professor, Department of Molecular Biology and Genetics, Aarhus University (tenured 2010).
2003-2004:    Post-doctoral research fellow at Case Western Reserve University, Cleveland, USA (laboratory of Vivien Yee).
2001-2003:    Post-doctoral research fellow at the Cleveland Clinic Foundation, Cleveland, USA (joint project of the laboratories of Ganes Sen and Vivien Yee).

Fellowships

2004-2009: Hallas Møller Fellowship from the Novo Nordisk Foundation (Career development grant).
2002-2004: Post-doctoral research fellowship from Alfred Benzon Foundation.
2001-2002: Post-doctoral research fellowship from the Danish Natural Science Research Council.
1997-2000: PhD fellowship from the BIOTEK III program
1994-1994: ERASMUS fellowship to study one semester in Vienna

Awards

• ”2001 Milstein Young Investigator Award” awarded by The International Society for Interferon and Cytokine Research.

Committees and evaluation

• Founding chairman of the international seminar series (now the Kjeldgaard lectures) at the Department of Molecular Biology and Genetics, Aarhus University.
• Member of the Nomenclature Committee of the International Cytokine and Interferon Society.
• Co-organizer and chair of the “2010 Interferon Lambda focus workshop” organized as part of the Cytokines 2010 meeting in Chicago, USA.
• Member of the Scientific Advisory Board for the Cytokines 2015 meeting in Bamberg Germany.
• Main organizer of the 34th conference of the European Macrophage and Dendritic cell Society (EMDS) in Aarhus, Denmark, 2020.
• Member of the scientific evaluation committee, Leo Foundation (2019-present).
• Member of the Research Committee of the Department of Molecular Biology and Genetics. Responsibilities of this committee include research strategy, hiring and promotion of scientific staff and fundraising.

Editorial appointments and review

2010-2012: Member of the Editorial Board for Interferon and Cytokine Research.
2013- : Member of the Editorial Board for Genes and Immunity.


Supervision, past and current

Master students: 12 completed, 1 current.
PhD students: 7 completed, 2 current.
Post docs: 8 completed, 2 current.

Key collaborators

Prof. Jean Luc Imler
University of Strasbourg                     Antiviral immunity in insects
Prof. Søren R Paludan
Aarhus University                               Recognition of viral infection
Prof. Takashi Fujita
University of Kyoto                             OASL and RIG-I signaling
Prof. Markus Heim
Basel University Hospital                    How IFN-λ4 influences treatment and clearance of HCV
Prof. Thomas Pietschmann
TWINCORE                                         IFN-λ and HCV infections
Prof. Volker Thiel
University of Bern                              Effect of IFN-λ on coronavirus and the therapeutic application of IFN-λ against coronaviruses.
Dr. Andreas Wack
The Francis Crick Institute                 Therapeutic potential of IFN-λ in respiratory infections

Scientific interests

Recognition of viral infection and the subsequent establishment of an antiviral state in cells. In particular how viruses are recognized at a molecular level and how this recognition leads to signaling within the infected cell. This interest started with the OAS-RNase L pathway but more recently I have moved into the cGAS-STING pathway.
The biology of type III IFNs and how genetic variation in the type III IFN gene loci influences the ability of humans to clear viral infections.

Recent lectures (invited or at conferences)

•University of Strasbourg, Strasbourg, France, 2016. “The dual role of type III IFN in antiviral defense and control of pathogenic inflammation.”
•University Hospital Basel, Basel, Switzerland,2017. “The dual role of type III IFN inantiviral defense and control of pathogenic inflammation.
•University of Freiburg, Freiburg, Germany, 2017,  “The dual role of type III IFN inantiviral defense and control of pathogenic inflammation.
•Cytokines 2017, Kanazawa, Japan, 2017.“R285Q selectively impairs activation ofIRF3”.
•National Cancer Institute of Science, Bethesda, USA, 2018.“How Does IFN-λ Impair HCV Clearance?”
•Weizman Institute of Science, Rehovot, Israel, 2018. "IFR3 activation - Why Phosphorylation of S386 is crtitical"
•University of Glasgow, Glasgow, UK, 2019. "The dual role of type III IFN in antiviral defense and control of pathogenic inflammation"