Aarhus University Seal / Aarhus Universitets segl

Rune Dietz

Multiple Cytokine and Acute Phase Protein Gene Transcription in West Greenland Sledge Dogs (Canis familiaris) Dietary Exposed to Organic Environmental Pollutants

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Multiple Cytokine and Acute Phase Protein Gene Transcription in West Greenland Sledge Dogs (Canis familiaris) Dietary Exposed to Organic Environmental Pollutants. / Sonne, C.; Fonfara, S.; Dietz, R.; Kirkegaard, M.; Letcher, R. J.; Shahmiri, S.; Andersen, S.; Møller, P.

I: Archives of Environmental Contamination and Toxicology, Bind 53, Nr. 1, 2007, s. 110-118.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Sonne, C, Fonfara, S, Dietz, R, Kirkegaard, M, Letcher, RJ, Shahmiri, S, Andersen, S & Møller, P 2007, 'Multiple Cytokine and Acute Phase Protein Gene Transcription in West Greenland Sledge Dogs (Canis familiaris) Dietary Exposed to Organic Environmental Pollutants', Archives of Environmental Contamination and Toxicology, bind 53, nr. 1, s. 110-118. <http://www.springerlink.com/content/g402l33734273438/fulltext.pdf>

APA

Sonne, C., Fonfara, S., Dietz, R., Kirkegaard, M., Letcher, R. J., Shahmiri, S., Andersen, S., & Møller, P. (2007). Multiple Cytokine and Acute Phase Protein Gene Transcription in West Greenland Sledge Dogs (Canis familiaris) Dietary Exposed to Organic Environmental Pollutants. Archives of Environmental Contamination and Toxicology, 53(1), 110-118. http://www.springerlink.com/content/g402l33734273438/fulltext.pdf

CBE

Sonne C, Fonfara S, Dietz R, Kirkegaard M, Letcher RJ, Shahmiri S, Andersen S, Møller P. 2007. Multiple Cytokine and Acute Phase Protein Gene Transcription in West Greenland Sledge Dogs (Canis familiaris) Dietary Exposed to Organic Environmental Pollutants. Archives of Environmental Contamination and Toxicology. 53(1):110-118.

MLA

Vancouver

Sonne C, Fonfara S, Dietz R, Kirkegaard M, Letcher RJ, Shahmiri S o.a. Multiple Cytokine and Acute Phase Protein Gene Transcription in West Greenland Sledge Dogs (Canis familiaris) Dietary Exposed to Organic Environmental Pollutants. Archives of Environmental Contamination and Toxicology. 2007;53(1):110-118.

Author

Sonne, C. ; Fonfara, S. ; Dietz, R. ; Kirkegaard, M. ; Letcher, R. J. ; Shahmiri, S. ; Andersen, S. ; Møller, P. / Multiple Cytokine and Acute Phase Protein Gene Transcription in West Greenland Sledge Dogs (Canis familiaris) Dietary Exposed to Organic Environmental Pollutants. I: Archives of Environmental Contamination and Toxicology. 2007 ; Bind 53, Nr. 1. s. 110-118.

Bibtex

@article{89eac5607e9e11dda5a8000ea68e967b,
title = "Multiple Cytokine and Acute Phase Protein Gene Transcription in West Greenland Sledge Dogs (Canis familiaris) Dietary Exposed to Organic Environmental Pollutants",
abstract = "Exposure levels of persistent organic pollutants - such as PCBs and DDTs - are high in Arctic apex predators and Inuit peoples, and are suspected to have negative impacts on their immune system. We conducted a controlled generational study on liver tissue and EDTA blood cytokine and acute phase protein (APP) mRNA expressions (RT-PCR) in West Greenland sledge dogs (Canis familiaris) using contaminated minke whale (Balaenoptera acutorostrata) blubber as a dietary pollutant source. Two of seven blood cytokine (IL-6, IL-12) and three of five APP (HP, HSP, FABP) expressions were lowest in the exposed group while the remaining five blood cytokine (IL-2, IL-10, IFN-{\~a}, TNF-{\'a}, TGF-{\^a}) and two APP (MT1 and MT2) expressions were highest in the exposed group. In liver tissue, three cytokine (IL-10, IFN-{\~a}, TNF-{\'a}) and two APP (MT1 and MT2) expressions were highest in the exposed group and the remaining cytokine and APP expressions lowest in the exposed group. Of these, the liver tissue expression of haptoglobin (HP) and fatty acid binding protein (FABP) was significantly lowest in the exposed group (both: p<0.05). As a consequence of our findings, we suggest that a daily intake of 50-200 g of polluted whale blubber is associated with a genotoxic decrease in HP and FABP gene expression in the liver of sledge dogs, and possibly of other top mammalian marine predators/consumers in the Arctic, indicating a restricted acute phase reaction and insufficient immune response. Finally, HP and FABP liver expression appear to be new and sensitive biomarkers of OHC exposure.",
keywords = "Acute phase proteins, Cytokines, Immune toxicity, Organohalogen pollutants, Sledge dog, West Greenland.",
author = "C. Sonne and S. Fonfara and R. Dietz and M. Kirkegaard and Letcher, {R. J.} and S. Shahmiri and S. Andersen and P. M{\o}ller",
year = "2007",
language = "English",
volume = "53",
pages = "110--118",
journal = "Archives of Environmental Contamination and Toxicology",
issn = "0090-4341",
publisher = "Springer New York LLC",
number = "1",

}

RIS

TY - JOUR

T1 - Multiple Cytokine and Acute Phase Protein Gene Transcription in West Greenland Sledge Dogs (Canis familiaris) Dietary Exposed to Organic Environmental Pollutants

AU - Sonne, C.

AU - Fonfara, S.

AU - Dietz, R.

AU - Kirkegaard, M.

AU - Letcher, R. J.

AU - Shahmiri, S.

AU - Andersen, S.

AU - Møller, P.

PY - 2007

Y1 - 2007

N2 - Exposure levels of persistent organic pollutants - such as PCBs and DDTs - are high in Arctic apex predators and Inuit peoples, and are suspected to have negative impacts on their immune system. We conducted a controlled generational study on liver tissue and EDTA blood cytokine and acute phase protein (APP) mRNA expressions (RT-PCR) in West Greenland sledge dogs (Canis familiaris) using contaminated minke whale (Balaenoptera acutorostrata) blubber as a dietary pollutant source. Two of seven blood cytokine (IL-6, IL-12) and three of five APP (HP, HSP, FABP) expressions were lowest in the exposed group while the remaining five blood cytokine (IL-2, IL-10, IFN-ã, TNF-á, TGF-â) and two APP (MT1 and MT2) expressions were highest in the exposed group. In liver tissue, three cytokine (IL-10, IFN-ã, TNF-á) and two APP (MT1 and MT2) expressions were highest in the exposed group and the remaining cytokine and APP expressions lowest in the exposed group. Of these, the liver tissue expression of haptoglobin (HP) and fatty acid binding protein (FABP) was significantly lowest in the exposed group (both: p<0.05). As a consequence of our findings, we suggest that a daily intake of 50-200 g of polluted whale blubber is associated with a genotoxic decrease in HP and FABP gene expression in the liver of sledge dogs, and possibly of other top mammalian marine predators/consumers in the Arctic, indicating a restricted acute phase reaction and insufficient immune response. Finally, HP and FABP liver expression appear to be new and sensitive biomarkers of OHC exposure.

AB - Exposure levels of persistent organic pollutants - such as PCBs and DDTs - are high in Arctic apex predators and Inuit peoples, and are suspected to have negative impacts on their immune system. We conducted a controlled generational study on liver tissue and EDTA blood cytokine and acute phase protein (APP) mRNA expressions (RT-PCR) in West Greenland sledge dogs (Canis familiaris) using contaminated minke whale (Balaenoptera acutorostrata) blubber as a dietary pollutant source. Two of seven blood cytokine (IL-6, IL-12) and three of five APP (HP, HSP, FABP) expressions were lowest in the exposed group while the remaining five blood cytokine (IL-2, IL-10, IFN-ã, TNF-á, TGF-â) and two APP (MT1 and MT2) expressions were highest in the exposed group. In liver tissue, three cytokine (IL-10, IFN-ã, TNF-á) and two APP (MT1 and MT2) expressions were highest in the exposed group and the remaining cytokine and APP expressions lowest in the exposed group. Of these, the liver tissue expression of haptoglobin (HP) and fatty acid binding protein (FABP) was significantly lowest in the exposed group (both: p<0.05). As a consequence of our findings, we suggest that a daily intake of 50-200 g of polluted whale blubber is associated with a genotoxic decrease in HP and FABP gene expression in the liver of sledge dogs, and possibly of other top mammalian marine predators/consumers in the Arctic, indicating a restricted acute phase reaction and insufficient immune response. Finally, HP and FABP liver expression appear to be new and sensitive biomarkers of OHC exposure.

KW - Acute phase proteins

KW - Cytokines

KW - Immune toxicity

KW - Organohalogen pollutants

KW - Sledge dog

KW - West Greenland.

M3 - Journal article

VL - 53

SP - 110

EP - 118

JO - Archives of Environmental Contamination and Toxicology

JF - Archives of Environmental Contamination and Toxicology

SN - 0090-4341

IS - 1

ER -