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Roy E. Weber

Professor emeritus

Curriculum Vitae

PERSONAL & COORDINATES

- Born in Berea, Cape Province, South Africa; Danish Citizen. Two children: Natalie E. and Oliver J.

- Address: Zoophysiology, Department of Bioscience, Building 131, Aarhus University, 8000 Aarhus C.

- Phone: +45 8942 2599; Cellular Ph.: +45 2815 4833; Fax: +45 89 422586.

 

ACADEMIC AND HONORARY DEGREES, AWARDS

- B.Sc. & B.Sc.(Hons), Zoology/Biological Chemistry, University of Cape Town, South Africa (1958 & '60)

- ‘Doctorandus' & Dr. Phil., Animal Physiology, Leiden University, The Netherlands (1964 & '65)

- Ridder af Dannebrogordenen ('Knight of the Danish Flag'), bestowed by Queen Margrethe (1987)

- Honorary Doctorate (Dr. Phil. Honoris causa) Johannesburg Rand Afrikaans University (1999)

- ‘August Krogh' Distinquished Lecturer of American and Scandinavian Physiological Societies, at XXXV International Congress of Physiological Sciences, San Diego (2005).

- Paul Harris Fellow (bestowed by Rotay Foundation of Rotary International) for Furtherance of Better Understanding among Peoples of the World (2018).

MAJOR INSTITUTIONAL POSITIONS

- Research Assistant, Council for Scient. & Industr. Research, Cape Town (1960)

- Research Associate, Animal Physiology, Leiden Univ., The Netherlands (1960-65)

- Faculty Appointment, Netherlands Institute for Sea Research, Texel, Netherlands (1965-72)

- Sabbatical Year, Duke Univ. Marine Lab., Beaufort, North Carolina, USA (1973-74)

- Faculty Appointment, Institute of Zoology and Zoophysiology, Aarhus University (1972-1978)

- Professor of Ecophysiology, Odense Univ., Denmark (1978-88)

- Sabbatical Year, Physiology Research Lab., Scripps Institution of Oceanography, San Diego, Cal­ifornia (1984-85)

- Director of SNF-funded Danish Centre Respiratory Physiological Adaptation (1995-01)

- Professor of Zoophysiology, Aarhus Univ., Denmark (1988-2008)

- Professor Emeritus, Zoophysiology, Institute of Biological Sciences, Aarhus Univ., (2009- )

 

OTHER ACADEMIC & COUNCIL MEMBERSHIPS;  EXPEDITIONS

- Secretary, Marine Biology Committee, Royal Netherlands Academy of Sciences (1968-72)

- Alpha Helix expedition to the Amazon (National Science Foundation, USA) (1976)

- Board Member, European Society for Comparative Physiology and Biochemistry (1981-94)

- Member, Danish Natural Science Research Council ‘SNF' (1983-87)

- Member, Marine Science and Tech­nology Committee, Danish Ministry of Education (1984-87)

- Member, Danish Natural Science Academy (1985-)

- Member, "Hav-90", Marine Research Advisory Council, Danish Environmental Ministry (1987-93)

- Coordinator, EC (EU) Research Programme 'Phys­iolo­gical and Bio­che­mical Ap­proach­es to Assessment of Pollution in Estuarine and Coastal Ecosystems: Oxygen Depletion' (1988-92)

- Leader, Danish Environmental Ministry ("Hav-90") Research Programme on "Interactive effects of oxygen depletion and heavy metals in marine benthic organisms" (1989-92)

- Evaluator, Core Programme, South African Foundation for Research Development (1991-95)

- Member, Danish National Committee for Physiology (Internat. Union of Physiol. Sciences) (1992- )

- Elected Member, Academia Europaea (1993 -)

- Advisory Board, Norwegian Natural Science and Technology Research Council 1994-1997

- President of European Society for Comparative Physiology and Biochemistry (ESCPB) (1994-98)

- Andes Mountains High Altitude Studies, Clinicum Laboratorio Automatizado, Iquique, Chile and Lab.Transporte de Oxígeno, Universidad Cayetano Heredia, Lima, Peru (1998, 1999 )

- Member, User Selection Panel ASTRID of ISA (Institute for Storage Ring Facilities at Aarhus) (2002-2008)

- Contractor EU shared-cost RTD action "Neuroglobin and the survival of the neuron" (2001-07)

- Member, 'Det Lærde Selskab' (The Learned Society) (2010 - ) 

 

EDITOR/EDITORIAL BOARD MEMBERSHIP

Netherlands Journal of Sea Research (editor 1970-85; editorial board member 1985-98), Hemoglobin (1977-85), Marine Biology Letters (1979-84), Molecular Physiology (1980-86), Journal of Experimental Marine Biology and Ecology (1984-), Advances in Comparative and Environmental Physiology (1985-94), Journal of Comparative Physiology B (1986-91), Physiological Reviews (1987-93), Physiological Zoology (1988-96), News in Physiological Sciences (NIPS) (1995-2003), Progress in Fish Research (1998-2001), Life-X-Y Online Edition (2000-2003), International Archives of Bioscience (2003-), Ecological and Environmental Physiology Series (Oxford Book Series) (2003-).

 

PUBLICATIONS

Approx. 270 original articles and chapters in international journals and books; (Co-)editor of 3 books.

Recent Publications (2010 - present, excluding Abstracts) 

270. Signore, AV., Paijmans, J.L.A., Hofreiter, M., Fago, A., Weber, R.E., Springer, M.S., Campbell, K.L. (2019). Emergence of a chimeric globin pseudogene and increased hemoglobin oxygen affinity underlie the evolution of aquatic specializations in Sirenia. Mol. Biol. Evol. 36 (6), 1134-1147.

269. Jendroszek, A., Malte, H., Overgaard, C.B., Beedholm, K., Natarajan, C., Weber, R.E., Storz, J.F. and Fago, A. (2018). Allosteric mechanisms underlying the adaptive increase in hemoglobin-oxygen affinity of the bar-headed goose. J. Exp. Biol. 221(Pt 18). pii: jeb185470. doi: 10.1242/jeb.185470.

268. Van den Thillart, G., I. Wilms, M. Nieveen, E. Burgerhout, R.E. Weber and F. Witte (2018). Hypoxia-induced changes in hemoglobins of Lake Victoria cichlids. J. Exp. Biol. 221 jeb177832. doi:10.1242/jeb.177832

267. Campbell, K.L., M.J. Gaudry, K. He, H. Suzuki, Y. Zhang, X.-L.Jiang and R.E. Weber (2018). Altered hemoglobin co-factor sensitivity does not underlie the evolution of fossorial specializations in the family Talpidae. Comp. Physiol. Biochem. B. 224, 150-155.

266. Natarajan, C., A. Jendroszek, A. Kumar, R.E. Weber, J.R.H. Tame, A. Fago and J.F. Storz (2018). Molecular basis of hemoglobin adaptation in the high-flying bar-headed goose. PLoS Genetics 14, 4, 19p.

265. Weber, R.E., J.U.M. Jarvis, A. Fago and N.C. Bennett (2017). O2 binding and CO2 sensitivity in hemoglobin from subterranean African mole rats. J. Exp. Biol. 220 (21), 3939-3948.

264. Kumar, A., C. Natarajan, H.  Moriyama, C.C. Witt, R.E. Weber, A. Fago and J.F. Storz (2017). Stability-mediated epistasis restricts accessible mutational pathways in the functional evolution of avian hemoglobin. Mol. Biol. Evol. 34 (5), 1240-1251.

263. Natarajan, C.J., F.C. Hoffmann, R.E. Weber, A. Fago, C.C. Witt and J.F. Storz (2016). Predictable convergence in hemoglobin function has unpredictable molecular underpinnings. Science 354 (6310), 336-339.

262. Natarajan, C, J. Projecto-Garcia, H. Moriyama, R.E. Weber,  V. Muñoz-Fuentes, A.J. Green, C. Kopuchian, P.L. Tubaro, L. Alza, M. Bulgarella, M.M. Smith, R.E. Wilson, A. Fago, K.G. McCracken, J.F. Storz (2015). Convergent evolution of hemoglobin function in high-altitude Andean waterfowl involves limited parallelism at the molecular sequence level. PLoS Genetics, 2015 Dec 4;11(12):e10055681. doi 10.1371/journal.pgen.1005681.

261.  Storz, J.F., C. Natarajan, H. Moriyama, F.G. Hoffman, T. Wang, A. Fago, H. Malte, J. Overgaard  and R.E. Weber (2015). Oxygenation properties and isoform diversity of snake hemoglobins. Am. J. Physiol., Reg. Integr. Comp. Physiol. 309,R1178-R1191.

260. Galen, S.C., C. Natarajan, H. Moriyama, R.E. Weber, A. Fago, Ph.M. Benham, A.N. Chavez, Z. A. Cheviron, J.F. Storz, C.C. Witt (2015). Contribution of a mutational hotspot to the functional evolution of avian hemoglobin. Proc. Natl. Acad. Sci. U.S.A. (PNAS) 112 (45), 13958-13963.

259. Janecka, J.E., S.S.E. Nielsen, S.D. Andersen, F.G. Hoffmann, R.E. Weber, T. Andersen, J.F. Storz and A. Fago (2015). Genetically-based low oxygen-affinities of felid hemoglobins: lack of biochemical adaptation to high-altitude hypoxia in the snow leopard. J. Exp. Biol. 218, 2402-2409.

258. Tufts, D.M., C. Natarajan, I. G. Revsbech, J. Projecto-Garcia,  F.G. Hoffmann, R.E. Weber, A. Fago, H. Moriyama, and J. Storz (2015) Epistasis constrains mutational pathways of hemoglobin adaptation in high-altitude pikas. Mol. Biol. Evol. 32, 287-298.

257. Natarajan, C.,F.G. Hoffmann, H.C. Lanier, C.C. Wolf, Z.A. Cheviron, M.L. Spangler, R.E. Weber, A. Fago, J.F. Storz (2015) Intraspecific polymorphism, interspecific divergence, and the origins of function-altering mutations in Deer Mouse hemoglobin (2014). Mol. Biol. Evol. 32(4), 978-997.

256. Damsgaard, C., I. Findorf, S. Helbo, Y. Kocagoz, R. Buchanan, Do Thi Thanh Huong, R.E. Weber, A. Fago, M. Bayley and  T. Wang (2014) High blood oxygen affinity in the air-breathing swamp eel Monopterus albus. Comp.  Biochem Physiol., Comp.  Biochem. Physiol., 178A, 102-108.

255. Cheviron, Z.A., Natarajan, C., Projecto-Garcia, J., Eddy, D.K., Jones, J., Carling, M.D., Witt, C.C., Moriyama, H., Weber, R.E., Fago, A. and Storz, J.F. (2014). Integrating evolutionary and functional tests of adaptive hypotheses: A case study of altitudinal differentiation in hemoglobin function in an Andean sparrow, Zonotrichia capensis. Molecular Biology and Evolution. Mol. Biol. Evol. 31, 2948-2962.

254. Weber, R.E., A. Fago, K.C. Campbell (2014).  Enthalpic partitioning of the reduced temperature sensitivity of O2 binding in bovine hemoglobin. Comp. Biochem. Physiol. A. 176, 20-25. 

253. Weber, R.E. (2014). Enthalpic consequences of reduced chloride binding in a high-altitude frog (Telmatobius peruvianus) haemoglobin. J. Comp. Physiol. B, J. Comp. Physiol. B, 184, 613-621.        DOI 10.1007/s00360-014-0823-2.

252. Projecto-Garcia, J., C. Natarajan, H. Moriyama, R.E. Weber, A. Fago, Z.A. Cheviron, R. Dudley, J.A. McGuire,  C.C. Witt and J.F. Storz. (2013). Repeated elevational transitions in hemoglobin function during the evolution of Andean hummingbirds. PNAS 110 (51) 20669-20674. http://www.pnas.org/content/early/2013/11/27/1315456110.full.pdf+html .

251. Revsbech, I.G., D.M. Tufts, J. Projecto-Garcia, H. Moriyama, R.E. Weber, A.  Fago and J.F. Storz, J.F. (2013) Hemoglobin function and allosteric regulation in semi-fossorial rodents (family Sciuridae) from different altitudinal ranges. J. Exp. Biol. 216, 4274-4271. (Commentary in JEB ; JEB 'Outstanding paper of 2013)

250. Weber, R.E., A. Fago, H. Malte, J.F. Storz and T.A. Gorr (2013) Lack of conventional oxygen-linked proton and anion binding sites does not impair allosteric regulation of oxygen binding in dwarf caiman hemoglobin. Amer. J. Physiol. 305, R300-R312. (Selecterd by Faculty of 1000)

249. Natarajan, C., N. Inoguchi, R.E. Weber, A. Fago, H. Moriyama, and J.F. Storz (2013). Epistasis among conditionally adaptive mutations in Deer mouse hemoglobin. Science. 340, 1324-1327. (Selected by Faculty of 1000; Commentary in Science and Nature)

248. Inoguchi, Noriko, J.R. Oshlo, C. Natarajan, R.E. Weber, A. Fago, J.F. Storz, and H. Moriyama(2013).  Deer-mouse hemoglobin exhibits a lowered oxygen affinity owing to mobility of the E helix. Acta Crystallographica. Section F, 69, 393-398.  http://dx.doi.org/10.1107/S1744309113005708.

247. Helbo, S., A. Fago and R.E. Weber (2013). Expression patterns and adaptive functional diversity of vertebrate myoglobins. Biochim. Biophys. Acta 9, 1832-1839.

246. Tufts, D.M., I.G. Revsbech, A.C. Zachary, R.E. Weber, A. Fago, J.F. Storz (2013). Phenotypic plasticity in blood-oxygen transport in highland and lowland deer mice. J. Exp. Biol. 216, 1167-1173. doi:10.1242 /jeb.079848. (JEB Cover)

245. Damsgaard, C., A. Fago, H. Malte, T. Burmester and R.E. Weber (2013). Allosteric regulation of O2 binding in hemocyanin of the giant African millipede, Archispirostreptus gigas. J. Exp. Biol. 216, 1616-1623. doi:10.1242/jeb.080861.

244. Grispo, M.T., C. Natarajan, J. ProjectoGarcia, H. Moriyama, R.E. Weber, and J.F. Storz (2012). Gene duplication and the evolution of hemoglobin isoform differentiation in birds. J. Biol. Chem. 287, 37647 - 37658.

243. Mairbäurl, H. and R.E. Weber (2012). Oxygen Transport by Hemoglobin. Comprehensive Physiology (Handbook of Physiology; American Physiological Society. Eds: P. Wagner and M. Hlastala) 2, 1463-1489.

242. Campbell, K.L., A.V. Signore, M. Harada and R.E. Weber (2012). Molecular and physicochemical characterization of hemoglobin from the high-altitude Taiwanese brown-toothed shrew (Episoriculus fumidus)). J. Comp. Physiol. 182, 821-829.

241. Storz, J.F., R.E. Weber and A. Fago (2012) Oxygenation properties and oxidation rates of mouse hemoglobins that differ in reactive cysteine content. Comp. Biochem. Physiol. 161A, 265-270.

240. Signore, A.V., J. Stetefeld, R.E. Weber and K.L. Campbell (2012). Origin and mechanism of thermal insensitivity in mole hemoglobins: a test of the ‘additional’ chloride binding site hypothesis. J. Exp. Biol. 215(3):518-525. [doi:10.1242/jeb.063669].

239. M. Blank, M., J. Wollberg, F. Gerlach, K. Reimann, A. Roesner, T. Hankeln, A. Fago,  R.E. Weber, and T. Burmester (2011) A membrane-bound vertebrate globin. PLoS One 6, (9) e25292 (9 pages).

238. Weber, R.E. (2011).  ICCPB2011: A new focus on Comparative Physiology and Biochemistry in "The Land of the Rising Sun”. Comp. Physiol. Biochem. (Japan), 28(2), 218-218.

237. Natarajan C, X. Jiang, A. Fago, R.E. Weber, H. Moriyama H and J.F. Storz (2011) Expression and purification of recombinant hemoglobin in Escherichia coli. P L o S ONE 6 (5), p. 1-7, e20176. doi:10.1371/journal.pone. 0020176

236. Weber, R.E. and K.L. Campbell (2910). Temperature  dependence of O2 affinity of vertebrate haemoglobins: Adaptations to heterothermy. Acta Physiologica, 202, 549-562.

235. Van Aardt, W.J. and R.E. Weber (2010). Respiration and hemoglobin function in the giant African bullfrog Pyxicephalus adspersus Tschudi (Anura: Pyxicephalidae) during rest, exercise and dormancy.  African Journal of Herpetology, 59: 2, 173-190.

234. Weber, R.E. and F.B. Jensen. (2010). Respiratory adaptations in lungfish blood and hemoglobin. In: the Biology of Lungfishes. Chapter 11. Eds.: Jørgensen, J.M. and J. Joss. Science Publishers, Inc. Enfield, New Hampshire 03478, USA. Pp. 283-303.

233. Campbell, K.C., J.F. Storz, A.V. Signore, H. Moriyama, K.C. Catania, A.P. Payson, J. Bonaventura, J. Stetefeld, and R.E. Weber.  (2010) Molecular basis of a novel adaptation to hypoxic-hypercapnia in a strictly fossorial mole. BMC Evol. Biol. 10:214 (pages 1-14). ('Highly accessed')

232. Storz, J.F., A.M. Runck, H. Moriyama, R.E. Weber and A. Fago (2010). Genetic differences in hemoglobin function between highland and lowland deer mice. J. Exp. Biol. 213, 2565-2574. (JEB Cover)

231. Runck, A.M., R.E. Weber, A. Fago, J.F. Storz (2010). Evolutionary and functional properties of a two-locus β-globin polymorphism in Indian house mice. Genetics, 184, 1121- 1131.

230. Geuens, E., D. Hoogewijs, M. Nardini, E. Vinck, A. Pesce, L. Kiger, A. Fago,  L. Tilleman, S. De Henau, M. Marden, R.E. Weber, S. van Doorslaer, J. Vanfleteren, L. Moens; M. Bolognesi and S. Dewilde (2010). Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural properties. BMC Biochemistry. 11:17.

229. Campbell, K.L., J.E.E. Roberts,  L.N. Watson, J. Stetefeld, A.M. Sloan, A.V. Signore, J. W. Howatt, J.R.H. Tame, N. Rohland, J.J. Austin, T.-J. Shen, M. Hofreiter, C. Ho, R.E. Weber and A.Cooper (2010). Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance. Nature Genetics. 42, 536-540. (doi:10.1038/ng.574).

228. Weber, R.E. , K.L. Campbell, A. Fago, Malte, H. and F.B. Jensen (2010) ATP-induced temperature independence of hemoglobin-O2 affinity in heterothermic billfish. J. Exp. Biol. 213, 1579-1585.

Curriculum Vitae

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