Rikke Nørregaard

PhD, Dr. Med., Lektor

Curriculum Vitae

EDUCATION:

2020                 Dr. Med. in Medicine, Aarhus University  

2010                 Diploma of Leadership, VIA University College, Aarhus.

2007                 Ph.D. in Medicine, Aarhus University.

2001                 Master of Science in Biomedicine, University of Southern Denmark.

 

CURRENT POSITION:

2012 - :            Associate Professor, Depart. of Clinical Medicine, Aarhus University.

 

PROFESSIONAL EXPERIENCE:

2009 - 2012     Assistant Professor, Depart. of Clinical Medicine, Aarhus University

2007 - 2009     Post Doc., Depart. of Clinical Medicine, Aarhus University.

2004 - 2007     DaCRA scholarship, PhD at Aarhus University.

2003 - 2004     Research assistant, The Water and Salt Center, Aarhus University.

2002                Research assistant, Physiology and Pharmacology, University of Southern Denmark.

 

RESEACH STAYS ABROAD:

2008               Post Doc., Institute for Pediatric Urology, Weill Cornell Medical College, New York, USA.  

2002 - 2003    Research fellow, Institut de Pharmacologie et de Toxicologie, Lausanne University,          Switzerland. 

 

PUBLICATION STATISTICS:

As per April 2020, my publications list contains 94 publications in international peer-reviewed journals including two Book chapters: e.g. Kidney Int. (JiF 8.5); J Am Soc Nephrol (JiF 9.3); Theranotics (JiF 7.8), Scientific Reports (JiF 5.8), Nanomedicine (JiF 6.4), Acta Physiologica (JiF 6.0). Within the subject area “Nephrology and Urology” 90% of my publications have been published in the top 20% journals29 as senior author and 11 as first author. H-index: 23, i10-index: 42, Citations: 1549.

 

RESEARCH AREAS: 

Physiological regulation of kidney function and pathophysiological mechanisms in acute and chronic kidney diseases including integrated physiology, pathophysiology, animal test systems, and in vivo pharmacology. Detailed cell biological, molecular biological, physiological and pathophysiological studies of the regulation of COX-2 and prostaglandins including regulation of water and salt metabolism in complex kidney diseases, including acute and chronic kidney injury as well as renal transplantation. Established human kidney slice models to study regulation of renal injury directly in human tissue. 

 

CURRENT BOARD AND COMMITTEE SERVICE:

2020 -     Member of Steering committee for interdisciplinary network initiative at Health, AU

2020 -     Board member of AU-Health committee for screening for duplicate texting.

2019 -     Member of Initiation and Application committee, The Open Discovery Network (ODIN), AU.

2018 -     Board member, Basic Science Committee, ESOT, EU.

2017-      Mentor at the Business and Innovations Honours Program at Health, AU

2017-      International Ambassador and board member, KCVD Leadership Committee, Council on The    Kidney in Cardiovascular Disease, USA

2015-      Editorial board member: AJP Renal Physiology, USA

2015-2017   Board member, PhD day Organizing Committee, Aarhus University

2014-      Board member, Executive Committee, Institute of Clinical Medicine, Aarhus University

2013 -     Vice-chair, Epithelial Transport Interest Group, American Physiological Society, USA

2013 -     Board member, Organizing Committee for ETG symposiums at Experimental Biology, USA

2014 -     Member, review panel for abstract to American Society of Nephrology, Kidney Week, USA

2012 -     Editorial board member: Frontiers in Renal and Epithelial Physiology

2012 -     Visting professor at Zhongzhou University, China.

2009 - 2011    Expert board member, Astellas Pharma Global Development – EU, The Netherlands

2009 -     Member, American Society of Nephrology and American Physiological Society, USA

2007 -     Member, Danish Nephrology Society (DNS)

 

REVIEW ACTIVITIES:

2015-      PhD Midterm evaluation (n = 3)

2014-      Chairman for PhD assessment committee (n = 7)

2014 -     Official opponent of PhDs in Denmark, Brazil, Sweden and The Netherlands.

2014 -     Grant evaluation committee work for: The Research Foundation – Flanders (FWO), The          France Research Foundation, The British Heart Foundation, The British Kidney Foundation.

2014 -     Member, assessment committee for assistant and associate professorships at Aarhus              University and University of Southern Denmark.

Ad hoc referee for more than 15 journals, e.g. JANS, Am J Physiology, Kidney Int, PlosOne, Acta Physiol Scand, Pediatrics, Pflügers Archiv.

 

HONORS AND AWARDS:

2019        Awarded Hallas-Møller Ascending Investigator Grant (10 Mill DKK)

2015        Paper of the Year in AJP Renal

2006        Novo Nordisk PhD Plus Award, Novo Nordisk, Denmark

2005        Best Oral Presentation, PhD day at Aarhus University

2001        Best Poster Presentation, Annual Meeting in German Physiological Society, Berlin, Germany

 

SUPERVISION:

Ongoing as main supervisor: 3 Post Doc, 3 PhD students, 1 research assistant and 2 master students Completed as main supervisor: 2 Post Doc, 5 PhD students, 3 research year students and 5 master students. Ongoing as co supervisor: 3 PhD students and 1 research year student. Completed as co supervisor: 4 PhD students and 6 research year students. 

 

FUNDING ID (major grants as PI over 200,000 kr.):

2007-2010    The significance of cyclooxygenase type 2 (COX-2) mediated prostaglandin synthesis for  the regulation of renal function in obstructive nephropathy; The Danish Council for Independent Research - Medical Sciences (FSS): 2,178,820 kr.  

2009-2012    Identification of signal pathways, which are responsible for the regulation of COX-2 in      complex kidney diseases; Lundbeck Foundation: 895,000 kr.   

2012-2015    Free radicals – Friends or Foes? Molecular mechanisms involved in the regulation of          oxidative stress in complex renal diseases; Lundbeck Foundation: 989,541 kr.

2013-2016    Free radicals – Friends or Foes? Molecular mechanisms involved in the regulation of          oxidative stress in complex renal diseases; Karen Elise Jensens Fond: 1,000,000 kr.

2014-2017    The effect of Metformin on impaired renal function in response to complex kidney            diseases; Danish Diabetes Academy: 550,000 kr. PhD Scholarship

2016-2020    Can we target fibrosis to prevent renal function decline in CKD?; Aarhus University          Research Foundation: 2,160,854 kr.

2016-2019    Prostaglandin E2 receptors as therapeutic targets in CKD; The Danish Council for              Independent Research - Medical Sciences (FSS): 1,961,218 kr.

2017-2020    Karakterisering af nye mekanismer, der beskytter mod udvikling af fibrose i kronisk          Nyresygdomme; Edith Waagens og Frode Waagens Fond: 250,000 kr.

2017-2021    Human precision-cut tissue slices as a tool to study fibrosis progression in children;Hildur  og Dagny Jacobsens Mindefond: 200,000 kr.

2017-2021    Indoleamine 2,3-dioxygenase and cyclooxygenase-2 as therapeutic targets in renal          fibrosis; Lundbeck Foundation: 1,400,000 kr. Post doc grant for Dr. Henricus Mutsaers

2017-2018    Molecular mechanisms responsible for fibrosis development in chronic kidney disease;      Aarhus University Research Foundation: 322,500 kr. Visiting guest researcher grant for Prof. Tae-Hwan Kwon, School of Medicine, Kyungpook National University, Korea

2018-2021    Fibrose hos børn med misdannelser i urinvejene; Karen Elise Jensens Fond: 3,000,000    kr.  

2020-2025    Innovative delivery systems for gene-edited stem cell therapy to target renal fibrosis;      Novo Nordisk Foundation: 10,000,000 kr.