Institut for Biologi

Aarhus Universitets segl

Rasmus David Buchanan

Pharmacodynamics of propofol and alfaxalone in rattlesnakes (Crotalus durissus)

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisLetterpeer review



  • Mads F. Bertelsen, København Zoo, Universidade Estadual Paulista Julio de Mesquita Filho
  • ,
  • Rasmus Buchanan
  • Heidi M. Jensen
  • Cleo A.C. Leite, Universidade Federal de Sao Carlos, Universidade Estadual Paulista Julio de Mesquita Filho
  • ,
  • Augusto S. Abe, København Zoo
  • ,
  • Tobias Wang

To characterise the effect of two common induction agents, propofol and alfaxalone, on mean arterial blood pressure (MAP) and heart rate (HR), we equipped 19 adult South American rattlesnakes (Crotalus durissus) with an indwelling arterial catheter approximately 24 h prior to recording of baseline resting values. Then, seven snakes received alfaxalone (15 mg kg−1) intravascularly (IV) through the catheter, while groups two and three (both n = 6) received propofol (15 mg kg−1 IV). The first two groups were not handled, while the group 3 was manually restrained for 2 min for a mock injection of 0.2 ml saline into the ventral tail vein. Baseline HR was similar in all groups and handling caused a significant tachycardia (p = 0.031) in group three. When given IV to undisturbed animals, both propofol and alfaxalone induced a significant increase in HR (p = 0.0022 and p = 0.0045, respectively) lasting approximately 30 min, but with values only significantly exceeding baseline for the first 5 min for propofol and the first 10 min with alfaxalone. Handling caused a significant increase in MAP (p = 0.0313). Propofol did not affect MAP (p = 0.1064), while alfaxalone caused a marked hypertension (although only significant at 2 min; p = 0.031). Manual restraint significantly increases both HR and MAP, which may lead to a masking of true cardiovascular effects of anaesthetic agents.

TidsskriftComparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
Antal sider4
StatusUdgivet - jun. 2021

Bibliografisk note

Funding Information:
This study was funded by the Novo Nordisk Foundation Danish Natural Science Research Council (Natur og Univers, Det Frie Forskningsråd) , and FAPESP .

Publisher Copyright:
© 2021 The Authors

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