Preben Bo Mortensen

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

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DOI

  • Melissa A. Munn-Chernoff, University of North Carolina
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  • Emma C. Johnson, Washington University St. Louis
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  • Yi Ling Chou, Washington University St. Louis
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  • Jonathan R.I. Coleman, King's College London
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  • Laura M. Thornton, University of North Carolina
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  • Raymond K. Walters, Harvard University, Massachusetts Institute of Technology
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  • Zeynep Yilmaz, University of North Carolina
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  • Jessica H. Baker, University of North Carolina
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  • Christopher Hübel
  • Scott Gordon, Queensland Institute of Medical Research
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  • Sarah E. Medland, Queensland Institute of Medical Research
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  • Hunna J. Watson, University of North Carolina, Curtin University of Technology, University of Western Australia
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  • Héléna A. Gaspar, King's College London
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  • Julien Bryois, Karolinska Institutet
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  • Anke Hinney, University of Duisburg-Essen
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  • Virpi M. Leppä, Karolinska Institutet
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  • Manuel Mattheisen
  • Stephan Ripke, Harvard University, Massachusetts Institute of Technology, Charité – Universitätsmedizin Berlin
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  • Shuyang Yao, Karolinska Institutet
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  • Paola Giusti-Rodríguez, University of North Carolina
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  • Ken B. Hanscombe, King's College London
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  • Roger A.H. Adan, Utrecht University, Altrecht Mental Health Institute, University of Gothenburg
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  • Lars Alfredsson, Karolinska Institutet
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  • Tetsuya Ando, National Center of Neurology and Psychiatry Kodaira
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  • Ole A. Andreassen, University of Oslo
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  • Wade H. Berrettini, University of Pennsylvania
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  • Ilka Boehm, Technische Universität Dresden
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  • Claudette Boni, Institut National de la Santé et de la Recherche Médicale
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  • Vesna Boraska Perica, Wellcome Sanger Institute, University of Split
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  • Katharina Buehren, RWTH Aachen University
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  • Roland Burghardt, Klinikum Frankfurt/Oder
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  • Matteo Cassina, University of Padova
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  • Sven Cichon, University of Basel, Jülich Research Centre
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  • Maurizio Clementi, University of Padova
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  • Roger D. Cone, University of Michigan, Ann Arbor
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  • Philippe Courtet, Universite de Montpellier
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  • Scott Crow, University of Minnesota
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  • James J. Crowley, University of North Carolina, Karolinska Institutet
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  • Unna N. Danner, Altrecht Mental Health Institute
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  • Oliver S.P. Davis, University of Bristol
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  • Martina de Zwaan, Hannover Medical School
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  • George Dedoussis, Harokopio University
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  • Daniela Degortes, University of Padova
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  • Janiece E. DeSocio, Seattle University
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  • Danielle M. Dick, Virginia Commonwealth University
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  • Dimitris Dikeos, University of Athens
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  • Christian Dina, Universite de Nantes
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  • Monika Dmitrzak-Weglarz, University of Medical Sciences Poznan
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  • Elisa Docampo, The Barcelona Institute of Science and Technology (BIST), Pompeu Fabra University, CIBER - Center for Biomedical Research Network
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  • Laramie E. Duncan, Stanford University
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  • Karin Egberts, University of Würzburg
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  • Stefan Ehrlich, Technische Universität Dresden
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  • Geòrgia Escaramís, The Barcelona Institute of Science and Technology (BIST), Pompeu Fabra University, CIBER - Center for Biomedical Research Network
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  • Tõnu Esko, University of Tartu, Massachusetts Institute of Technology
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  • Xavier Estivill, The Barcelona Institute of Science and Technology (BIST), Pompeu Fabra University, CIBER - Center for Biomedical Research Network, Centre for Genomic Regulation
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  • Anne Farmer, King's College London
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  • Angela Favaro, University of Padova
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  • Fernando Fernández-Aranda, University of Barcelona
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  • Manfred M. Fichter, Ludwig Maximilian University of Munich
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  • Krista Fischer, University of Tartu
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  • Manuel Föcker, University of Münster
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  • Lenka Foretova, Masaryk Memorial Cancer Institute
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  • Andreas J. Forstner, University of Basel, University of Marburg, University of Bonn
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  • Monica Forzan, University of Padova
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  • Christopher S. Franklin, Wellcome Sanger Institute
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  • Steven Gallinger, University of Toronto
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  • Ina Giegling, Martin Luther University Halle-Wittenberg
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  • Johanna Giuranna, University of Duisburg-Essen
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  • Fragiskos Gonidakis, University of Athens
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  • Philip Gorwood, INSERM U1266, Paris Descartes University
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  • Monica Gratacos Mayora, The Barcelona Institute of Science and Technology (BIST), Pompeu Fabra University, CIBER - Center for Biomedical Research Network
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  • Sébastien Guillaume, Universite de Montpellier
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  • Yiran Guo, University of Pennsylvania
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  • Hakon Hakonarson, University of Pennsylvania
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  • Konstantinos Hatzikotoulas, Wellcome Sanger Institute, Helmholtz Zentrum München - German Research Center for Environmental Health
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  • Joanna Hauser, University of Medical Sciences Poznan
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  • Johannes Hebebrand, University of Duisburg-Essen
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  • Sietske G. Helder, King's College London, Zorg op Orde
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  • Stefan Herms, University of Basel
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  • Beate Herpertz-Dahlmann, RWTH Aachen University
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  • Wolfgang Herzog, Heidelberg University 
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  • Laura M. Huckins, Wellcome Sanger Institute, Icahn School of Medicine at Mount Sinai
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  • James I. Hudson, Harvard University
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  • Hartmut Imgart, Eating Disorders Unit
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  • Hidetoshi Inoko, Tokai University
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  • Vladimir Janout, Palacký University Olomouc
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  • Susana Jiménez-Murcia, University of Barcelona
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  • Antonio Julià, Autonomous University of Barcelona
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  • Gursharan Kalsi, King's College London
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  • Deborah Kaminská, Charles University
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  • Leila Karhunen, University of Eastern Finland
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  • Andreas Karwautz, Medical University of Vienna
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  • Martien J.H. Kas, Utrecht University, University of Groningen
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  • James L. Kennedy, University of Toronto
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  • Anna Keski-Rahkonen, University of Helsinki
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  • Kirsty Kiezebrink, University of Aberdeen
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  • Youl Ri Kim, Inje University
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  • Kelly L. Klump, Michigan State University
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  • Gun Peggy S. Knudsen, Norwegian Institute of Public Health
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  • Maria C. La Via, University of North Carolina
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  • Stephanie Le Hellard, University of Bergen
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  • Robert D. Levitan, University of Toronto
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  • Dong Li, University of Pennsylvania
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  • Lisa Lilenfeld, The Chicago School of Professional Psychology
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  • Bochao Danae Lin, Utrecht University
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  • Jolanta Lissowska, M Skłodowska-Curie Cancer Center - Oncology Center
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  • Jurjen Luykx, Utrecht University
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  • Pierre J. Magistretti, King Abdullah University of Science and Technology, University of Lausanne
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  • Mario Maj, University of Campania Luigi Vanvitelli
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  • Katrin Mannik, University of Tartu, University of Lausanne
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  • Sara Marsal, Autonomous University of Barcelona
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  • Christian R. Marshall, University of Toronto
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  • Morten Mattingsdal, University of Oslo
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  • Sara McDevitt, University College Cork, Mid-Western Regional Hospital Limerick
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  • Peter McGuffin, King's College London
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  • Andres Metspalu, University of Tartu
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  • Ingrid Meulenbelt, Leiden University
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  • Nadia Micali, University of Geneva
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  • Karen Mitchell, Department of Veterans Affairs, Boston University
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  • Alessio Maria Monteleone, University of Campania Luigi Vanvitelli
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  • Palmiero Monteleone, University of Salerno
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  • Benedetta Nacmias, University of Florence
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  • Marie Navratilova, Masaryk Memorial Cancer Institute
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  • Ioanna Ntalla, Harokopio University
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  • Julie K. O'Toole, Kartini Clinic
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  • Roel A. Ophoff, University of California at Los Angeles, Erasmus University Rotterdam
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  • Leonid Padyukov, Karolinska Institutet
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  • Aarno Palotie, Massachusetts Institute of Technology, University of Helsinki, Harvard University
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  • Jacques Pantel, Institut National de la Santé et de la Recherche Médicale
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  • Hana Papezova, Charles University
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  • Dalila Pinto, Icahn School of Medicine at Mount Sinai
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  • Raquel Rabionet, Saint Joan de Déu Barcelona Children's Hospital, University of Barcelona
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  • Anu Raevuori, University of Helsinki
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  • Nicolas Ramoz, Institut National de la Santé et de la Recherche Médicale
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  • Ted Reichborn-Kjennerud, Norwegian Institute of Public Health, University of Oslo
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  • Valdo Ricca, University of Florence
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  • Samuli Ripatti, University of Helsinki
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  • Franziska Ritschel, Technische Universität Dresden
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  • Marion Roberts, King's College London
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  • Alessandro Rotondo, University of Pisa
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  • Dan Rujescu, Martin Luther University Halle-Wittenberg
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  • Filip Rybakowski, University of Medical Sciences Poznan
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  • Paolo Santonastaso, University of Padova
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  • André Scherag, Friedrich Schiller University Jena
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  • Stephen W. Scherer, University of Toronto
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  • Ulrike Schmidt, King's College London
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  • Nicholas J. Schork, J. Craig Venter Institute
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  • Alexandra Schosser, Medical University of Vienna
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  • Jochen Seitz, RWTH Aachen University
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  • Lenka Slachtova, Charles University
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  • P. Eline Slagboom, Leiden University
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  • Margarita C.T. Slof-Op't Landt, Center for Eating Disorders Ursula, Leiden University
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  • Agnieszka Slopien, University of Medical Sciences Poznan
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  • Sandro Sorbi, University of Florence, IRCCS Fondazione Don Carlo Gnocchi - Milano
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  • Beata Świątkowska, Nofer Institute of Occupational Medicine
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  • Jin P. Szatkiewicz, University of North Carolina
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  • Ioanna Tachmazidou, Wellcome Sanger Institute
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  • Elena Tenconi, University of Padova
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  • Alfonso Tortorella, University of Campania Luigi Vanvitelli, University of Perugia
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  • Federica Tozzi, STREMBLE Ventures Ltd
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  • Janet Treasure, King's College London
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  • Artemis Tsitsika, University of Athens
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  • Marta Tyszkiewicz-Nwafor, University of Medical Sciences Poznan
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  • Konstantinos Tziouvas, University of Athens
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  • Annemarie A. van Elburg, Altrecht Mental Health Institute, Utrecht University
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  • Eric F. van Furth, Center for Eating Disorders Ursula, Leiden University
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  • Gudrun Wagner, Medical University of Vienna
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  • Esther Walton, Technische Universität Dresden
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  • Elisabeth Widen, University of Helsinki
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  • Eleftheria Zeggini, Wellcome Sanger Institute, Helmholtz Zentrum München - German Research Center for Environmental Health
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  • Stephanie Zerwas, University of North Carolina
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  • Stephan Zipfel, University of Tübingen
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  • Andrew W. Bergen, BioRealm LLC, Oregon Research Institute
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  • Joseph M. Boden, University of Otago
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  • Harry Brandt, The Center for Eating Disorders
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  • Steven Crawford, The Center for Eating Disorders
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  • Katherine A. Halmi, Cornell University
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  • L. John Horwood, University of Otago
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  • Craig Johnson, Eating Recovery Center
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  • Allan S. Kaplan, University of Toronto
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  • Walter H. Kaye, Department of Psychiatry
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  • James Mitchell, University of North Dakota
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  • Catherine M. Olsen, Queensland Institute of Medical Research
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  • John F. Pearson, University of Otago
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  • Nancy L. Pedersen, Karolinska Institutet
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  • Michael Strober, University of California at Los Angeles
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  • Thomas Werge, Københavns Universitet
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  • David C. Whiteman, Queensland Institute of Medical Research
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  • D. Blake Woodside, University of Toronto, University Health Network
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  • Jakob Grove
  • Anjali K. Henders, University of Queensland
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  • Janne T. Larsen
  • Richard Parker, Queensland Institute of Medical Research
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  • Liselotte V. Petersen
  • Jennifer Jordan, University of Otago, Canterbury District Health Board
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  • Martin A. Kennedy, University of Otago
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  • Andreas Birgegård, Karolinska Institutet, Stockholm City Council
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  • Paul Lichtenstein, Karolinska Institutet
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  • Claes Norring, Karolinska Institutet, Stockholm City Council
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  • Mikael Landén, Karolinska Institutet, University of Gothenburg
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  • Preben Bo Mortensen
  • Renato Polimanti, Yale University, Department of Veterans Affairs
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  • Jeanette N. McClintick, Indiana University - Purdue University Indianapolis
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  • Amy E. Adkins, Virginia Commonwealth University
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  • Fazil Aliev, Virginia Commonwealth University, Karabuk University
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  • Silviu Alin Bacanu, Virginia Commonwealth University
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  • Anthony Batzler, Mayo Clinic Rochester, MN
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  • Sarah Bertelsen, Icahn School of Medicine at Mount Sinai
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  • Joanna M. Biernacka, Mayo Clinic Rochester, MN
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  • Tim B. Bigdeli, SUNY Downstate Medical Center
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  • Li Shiun Chen, Washington University St. Louis
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  • Toni Kim Clarke, University of Edinburgh
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  • Franziska Degenhardt, University of Bonn
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  • Anna R. Docherty, University of Utah
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  • Alexis C. Edwards, Virginia Commonwealth University
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  • Jerome C. Foo, Heidelberg University 
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  • Louis Fox, Washington University St. Louis
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  • Josef Frank, Heidelberg University 
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  • Laura M. Hack, Stanford University
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  • Annette M. Hartmann, Martin Luther University Halle-Wittenberg
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  • Sarah M. Hartz, Washington University St. Louis
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  • Stefanie Heilmann-Heimbach, University of Bonn
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  • Colin Hodgkinson, National Institutes of Health
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  • Per Hoffmann, University of Bonn, University of Basel
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  • Jouke Jan Hottenga, Vrije Universiteit Amsterdam
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  • Bettina Konte, Martin Luther University Halle-Wittenberg
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  • Jari Lahti, University of Turku
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  • Marius Lahti-Pulkkinen, University of Helsinki
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  • Dongbing Lai, Indiana University - Purdue University Indianapolis
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  • Lannie Ligthart, Vrije Universiteit Amsterdam
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  • Anu Loukola, University of Helsinki
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  • Brion S. Maher, Johns Hopkins University
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  • Hamdi Mbarek, Vrije Universiteit Amsterdam
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  • Andrew M. McIntosh, University of Edinburgh
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  • Matthew B. McQueen, University of Colorado Boulder
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  • Jacquelyn L. Meyers, SUNY Downstate Medical Center
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  • Yuri Milaneschi, University of Amsterdam
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  • Teemu Palviainen, University of Helsinki
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  • Roseann E. Peterson, Virginia Commonwealth University
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  • Euijung Ryu, Mayo Clinic Rochester, MN
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  • Nancy L. Saccone, Harvard University
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  • Jessica E. Salvatore, Virginia Commonwealth University
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  • Sandra Sanchez-Roige, Department of Psychiatry
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  • Melanie Schwandt, Boston University
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  • Richard Sherva, Harvard University
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  • Fabian Streit, Heidelberg University 
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  • Jana Strohmaier, Heidelberg University 
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  • Nathaniel Thomas, Virginia Commonwealth University
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  • Jen Chyong Wang, Icahn School of Medicine at Mount Sinai
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  • Bradley T. Webb, Virginia Commonwealth University
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  • Robbee Wedow, Harvard University, Massachusetts Institute of Technology, University of Colorado Denver
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  • Leah Wetherill, Indiana University - Purdue University Indianapolis
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  • Amanda G. Wills, University of Colorado Boulder
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  • Hang Zhou, Yale University, Department of Veterans Affairs
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  • Jason D. Boardman, University of Colorado Boulder, Mayo Clinic Rochester, MN
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  • Danfeng Chen, Massachusetts Institute of Technology
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  • Doo Sup Choi, University of Vermont
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  • William E. Copeland, Washington University St. Louis
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  • Robert C. Culverhouse, Johannes Gutenberg University Mainz
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  • Norbert Dahmen, University of New South Wales
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  • Louisa Degenhardt, Stanford University
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  • Benjamin W. Domingue, Heinrich Heine University Düsseldorf
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  • Mark A. Frye, Mayo Clinic Rochester, MN
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  • Wolfgang Gäbel, University of Edinburgh
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  • Caroline Hayward, Max Planck Institute of Psychiatry
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  • Marcus Ising, University of Minnesota
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  • Margaret Keyes, Heidelberg University 
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  • Falk Kiefer, Ludwig Maximilian University of Munich
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  • Gabriele Koller, University of Iowa
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  • John Kramer, King's College London
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  • Samuel Kuperman, University of Bonn
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  • Susanne Lucae, University of Minnesota
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  • Michael T. Lynskey, University of Bonn
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  • Wolfgang Maier, National Institute for Health and Welfare
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  • Karl Mann, Ludwig Maximilian University of Munich
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  • Satu Männistö, Max Planck Institute of Psychiatry
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  • Bertram Müller-Myhsok, University of Aberdeen
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  • Alison D. Murray, Indiana University - Purdue University Indianapolis
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  • John I. Nurnberger, Johns Hopkins University, Martin Luther University Halle-Wittenberg
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  • Ulrich Preuss, Vitos Hospital Herborn, University of Pittsburgh
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  • Katri Räikkönen, University of Helsinki
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  • Maureen D. Reynolds, University of Regensburg
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  • Monika Ridinger, University of Duisburg-Essen
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  • Norbert Scherbaum, Ludwig Maximilian University of Munich
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  • Marc A. Schuckit, Department of Psychiatry
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  • Michael Soyka, Ludwig Maximilian University of Munich, University of Regensburg
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  • Jens Treutlein, Heidelberg University 
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  • Stephanie H. Witt, Heidelberg University 
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  • Norbert Wodarz, Ludwig Maximilian University of Munich
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  • Peter Zill, University of Utah
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  • Daniel E. Adkins, University of Utah, University of California at San Diego
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  • Dorret I. Boomsma, Vrije Universiteit Amsterdam
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  • Laura J. Bierut, Washington University St. Louis
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  • Sandra A. Brown, Department of Psychiatry, Duke University
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  • Kathleen K. Bucholz, Washington University St. Louis
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  • E. Jane Costello, University of Chicago
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  • Harriet de Wit, National Institutes of Health
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  • Nancy Diazgranados, University of Helsinki
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  • Johan G. Eriksson, National Institute for Health and Welfare, Boston University
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  • Lindsay A. Farrer, Harvard University, Boston University, NIH/NIAAA
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  • Tatiana M. Foroud, Indiana University - Purdue University Indianapolis
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  • Nathan A. Gillespie, Virginia Commonwealth University
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  • Alison M. Goate, Icahn School of Medicine at Mount Sinai
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  • David Goldman, National Institutes of Health, Research Triangle Institute International
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  • Richard A. Grucza, Washington University St. Louis
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  • Dana B. Hancock, University of North Carolina
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  • Kathleen Mullan Harris, University of North Carolina, University of Connecticut
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  • Victor Hesselbrock, University of Colorado Boulder
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  • John K. Hewitt, University of Colorado Denver
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  • Christian J. Hopfer, Research Triangle Institute International
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  • William G. Iacono, Ludwig Maximilian University of Munich
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  • Eric O. Johnson, University of North Carolina, University of Pennsylvania
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  • Victor M. Karpyak, Mayo Clinic Rochester, MN
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  • Kenneth S. Kendler, Virginia Commonwealth University
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  • Henry R. Kranzler, VA Medical Center, University of Colorado Boulder
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  • Kenneth Krauter, McMaster University
  • ,
  • Penelope A. Lind, Queensland Institute of Medical Research
  • ,
  • Matt McGue, Ludwig Maximilian University of Munich
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  • James MacKillop, McMaster University, University of California at San Diego
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  • Pamela A.F. Madden, Washington University St. Louis
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  • Hermine H. Maes, Virginia Commonwealth University
  • ,
  • Patrik K.E. Magnusson, Karolinska Institutet
  • ,
  • Elliot C. Nelson, Washington University St. Louis
  • ,
  • Markus M. Nöthen, University of Bonn
  • ,
  • Abraham A. Palmer, Department of Psychiatry, Vrije Universiteit Amsterdam
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  • Brenda W.J.H. Penninx, Indiana University Bloomington
  • ,
  • Bernice Porjesz, SUNY Downstate Medical Center
  • ,
  • John P. Rice, Washington University St. Louis
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  • Marcella Rietschel, Heidelberg University 
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  • Brien P. Riley, Virginia Commonwealth University
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  • Richard J. Rose, Yale University
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  • Pei Hong Shen, National Institutes of Health
  • ,
  • Judy Silberg, Virginia Commonwealth University
  • ,
  • Michael C. Stallings, Research Triangle Institute International
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  • Ralph E. Tarter, University of Duisburg-Essen
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  • Michael M. Vanyukov, University of Duisburg-Essen
  • ,
  • Scott Vrieze, Ludwig Maximilian University of Munich
  • ,
  • Tamara L. Wall, Department of Psychiatry
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  • John B. Whitfield, Queensland Institute of Medical Research
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  • Hongyu Zhao, Flinders University
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  • Benjamin M. Neale, Harvard University, Massachusetts Institute of Technology
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  • Tracey D. Wade, University of Queensland
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  • Andrew C. Heath, Washington University St. Louis
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  • Grant W. Montgomery, Queensland Institute of Medical Research, University of Queensland, Yale University
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  • Nicholas G. Martin, Queensland Institute of Medical Research
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  • Patrick F. Sullivan, University of North Carolina, Karolinska Institutet
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  • Jaakko Kaprio, University of Helsinki
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  • Gerome Breen, King's College London
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  • Joel Gelernter, Yale University, Department of Veterans Affairs, University of North Carolina
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  • Howard J. Edenberg, Indiana University - Purdue University Indianapolis
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  • Cynthia M. Bulik, University of North Carolina, Karolinska Institutet
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  • Arpana Agrawal, Washington University St. Louis

Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = −0.19 to −0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.

OriginalsprogEngelsk
Artikelnummere12880
TidsskriftAddiction Biology
Sider (fra-til)e12880
ISSN1355-6215
DOI
StatusE-pub ahead of print - 2020

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