Preben Bo Mortensen

Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Dokumenter

DOI

  • J. Nissen, Københavns Universitet, Rigshospitalet
  • ,
  • Betina Trabjerg
  • M. G. Pedersen
  • Karina Banasik, Københavns Universitet
  • ,
  • Ole Birger Pedersen, Næstved Sygehus
  • ,
  • Erik Sørensen, Rigshospitalet
  • ,
  • Kaspar René Nielsen, Aalborg Universitet
  • ,
  • Christian Erikstrup
  • Mikkel Steen Petersen
  • Helene Martina Paarup, Odense Universitetshospital
  • ,
  • P. Bruun-Rasmussen, Københavns Universitet
  • ,
  • D. Westergaard, Københavns Universitet
  • ,
  • T. F. Hansen, Københavns Universitet, Danish Headache Centre, Rigshospitalet, Institute of Biological Psychiatry
  • ,
  • Carsten B. Pedersen
  • Thomas Werge, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Københavns Universitet
  • ,
  • Fuller Torrey, MD School of Medicine
  • ,
  • Henrik Hjalgrim, Statens Serum Institut, Rigshospitalet
  • ,
  • Preben Bo Mortensen
  • Robert Yolken, Johns Hopkins University Hospital
  • ,
  • Søren Brunak, Københavns Universitet
  • ,
  • Henrik Ullum, Rigshospitalet
  • ,
  • K. S. Burgdorf, Rigshospitalet

Increasing evidence shows that latent infections and inflammation is associated with cognitive and behavioral changes in humans. This case-control study investigates the association between Herpes Simplex Virus Type 1 (HSV-1) infection and C-reactive Protein (CRP) levels, and psychiatric disorders and suicidal behavior. Public health register data from 81,912 participants in the Danish Blood Donor Study, were reviewed to identify individuals registered with an ICD-10 code of any psychiatric diagnosis, or who had attempted or committed suicide. We found 1,504 psychiatric cases and 353 suicidal cases; for all cases, controls were frequency-matched by age and sex, resulting in 5,336 participants. Plasma samples were analyzed for IgG-class antibodies against HSV-1 and CRP. HSV-1 infection was associated with suicidal behavior (odds-ratio, 1.40; 95% confidence interval [CI] 1.11–1.77). Accounting for temporality, HSV-1 infection was associated with having first psychiatric disorder after the date of blood collection (incidence rate ration, 1.44; 95% CI, 1.05–1.95). No association between CRP and psychiatric disorders or suicidal behavior was found. The finding that HSV-1 was associated with suicidal behavior and first psychiatric disorder indicates that infection may play a role in the etiology and pathogenesis of suicidal behavior and development of psychiatric disorders.

OriginalsprogEngelsk
TidsskriftPsychoneuroendocrinology
Vol/bind108
Sider (fra-til)150-154
Antal sider5
ISSN0306-4530
DOI
StatusUdgivet - 2019

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Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

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