Preben Bo Mortensen

Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Anna E Bauer, University of North Carolina School of Medicine
  • ,
  • Xiaoqin Liu
  • Enda M Byrne, University of North Carolina School of Medicine
  • ,
  • Patrick F Sullivan, University of North Carolina School of Medicine, Karolinska Institutet
  • ,
  • Naomi R Wray, University of Queensland
  • ,
  • Esben Agerbo
  • Mette Nyegaard
  • Jakob Grove
  • Katherine L Musliner
  • Katja G Ingstrup, iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, National Centre for Register-based Research (NCRR), Aarhus University
  • ,
  • Benedicte M W Johannsen
  • Merete L Mægbæk
  • Yunpeng Wang, iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Mental Health Services Capital Region of Denmark, University of Oslo
  • ,
  • Merete Nordentoft, iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Mental Health Centre Copenhagen, Københavns Universitet
  • ,
  • Ole Mors
  • Anders D Børglum
  • Thomas Werge, iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Mental Health Services Capital Region of Denmark
  • ,
  • David M Hougaard, iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Statens Serum Institut
  • ,
  • Preben Bo Mortensen
  • Trine Munk-Olsen
  • Samantha Meltzer-Brody, School of Medicine, University of North Carolina

Postpartum psychiatric disorders are heritable, but how genetic liability varies by other significant risk factors is unknown. We aimed to (1) estimate associations of genetic risk scores (GRS) for major depression (MD), bipolar disorder (BD), and schizophrenia (SCZ) with postpartum psychiatric disorders, (2) examine differences by prior psychiatric history, and (3) compare genetic and familial risk of postpartum psychiatric disorders. We conducted a nested case-control study based on Danish population-based registers of all women in the iPSYCH2012 cohort who had given birth before December 31, 2015 (n = 8850). Cases were women with a diagnosed psychiatric disorder or a filled psychotropic prescription within one year after delivery (n = 5829 cases, 3021 controls). Association analyses were conducted between GRS calculated from Psychiatric Genomics Consortium discovery meta-analyses for MD, BD, and SCZ and case-control status of a postpartum psychiatric disorder. Parental psychiatric history was associated with postpartum psychiatric disorders among women with previous psychiatric history (OR, 1.14; 95% CI 1.02-1.28) but not without psychiatric history (OR, 1.08; 95% CI: 0.81-1.43). GRS for MD was associated with an increased risk of postpartum psychiatric disorders in both women with (OR, 1.44; 95% CI: 1.19-1.74) and without (OR, 1.88; 95% CI: 1.26-2.81) personal psychiatric history. SCZ GRS was only minimally associated with postpartum disorders and BD GRS was not. Results suggest GRS of lifetime psychiatric illness can be applied to the postpartum period, which may provide clues about distinct environmental or genetic elements of postpartum psychiatric disorders and ultimately help identify vulnerable groups.

OriginalsprogEngelsk
TidsskriftTranslational Psychiatry
Vol/bind9
Nummer1
Sider (fra-til)288
Antal sider13
ISSN2158-3188
DOI
StatusUdgivet - 2019

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