Preben Bo Mortensen

Attention-deficit hyperactivity disorder and anxiety disorders as precursors of bipolar disorder onset in adulthood

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Attention-deficit hyperactivity disorder and anxiety disorders as precursors of bipolar disorder onset in adulthood. / Meier, Sandra M; Pavlova, Barbara; Dalsgaard, Søren; Nordentoft, Merete; Mors, Ole; Mortensen, Preben B; Uher, Rudolf.

I: British Journal of Psychiatry, Bind 213, Nr. 3, 2018, s. 555-560.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Meier, Sandra M ; Pavlova, Barbara ; Dalsgaard, Søren ; Nordentoft, Merete ; Mors, Ole ; Mortensen, Preben B ; Uher, Rudolf. / Attention-deficit hyperactivity disorder and anxiety disorders as precursors of bipolar disorder onset in adulthood. I: British Journal of Psychiatry. 2018 ; Bind 213, Nr. 3. s. 555-560.

Bibtex

@article{2a404548b5924d81a974484ec4a54e3f,
title = "Attention-deficit hyperactivity disorder and anxiety disorders as precursors of bipolar disorder onset in adulthood",
abstract = "BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) and anxiety disorders have been proposed as precursors of bipolar disorder, but their joint and relative roles in the development of bipolar disorder are unknown.AimsTo test the prospective relationship of ADHD and anxiety with onset of bipolar disorder.METHOD: We examined the relationship between ADHD, anxiety disorders and bipolar disorder in a birth cohort of 2 409 236 individuals born in Denmark between 1955 and 1991. Individuals were followed from their sixteenth birthday or from January 1995 to their first clinical contact for bipolar disorder or until December 2012. We calculated incidence rates per 10 000 person-years and tested the effects of prior diagnoses on the risk of bipolar disorder in survival models.RESULTS: Over 37 394 865 person-years follow-up, 9250 onsets of bipolar disorder occurred. The incidence rate of bipolar disorder was 2.17 (95% CI 2.12-2.19) in individuals with no prior diagnosis of ADHD or anxiety, 23.86 (95% CI 19.98-27.75) in individuals with a prior diagnosis of ADHD only, 26.05 (95% CI 24.47-27.62) in individuals with a prior diagnosis of anxiety only and 66.16 (95% CI 44.83-87.47) in those with prior diagnoses of both ADHD and anxiety. The combination of ADHD and anxiety increased the risk of bipolar disorder 30-fold (95% CI 21.66-41.40) compared with those with no prior ADHD or anxiety.CONCLUSIONS: Early manifestations of both internalising and externalising psychopathology indicate liability to bipolar disorder. The combination of ADHD and anxiety is associated with a very high risk of bipolar disorder.Declaration of interestNone.",
keywords = "ADHD, Bipolar disorder, CHILD-BEHAVIOR CHECKLIST, COHORT, HIGH-RISK, MENTAL-ILLNESS, METAANALYSIS, PEOPLE, PREVALENCE, PSYCHOPATHOLOGY, SCHIZOPHRENIA, anxiety disorders, attention-deficit, developmental psychopathology, early identification of risk, externalising disorders, hyperactivity disorder, internalizing disorders",
author = "Meier, {Sandra M} and Barbara Pavlova and S{\o}ren Dalsgaard and Merete Nordentoft and Ole Mors and Mortensen, {Preben B} and Rudolf Uher",
year = "2018",
doi = "10.1192/bjp.2018.111",
language = "English",
volume = "213",
pages = "555--560",
journal = "British Journal of Psychiatry",
issn = "0007-1250",
publisher = "ROYAL COLL PSYCHIATRISTS",
number = "3",

}

RIS

TY - JOUR

T1 - Attention-deficit hyperactivity disorder and anxiety disorders as precursors of bipolar disorder onset in adulthood

AU - Meier, Sandra M

AU - Pavlova, Barbara

AU - Dalsgaard, Søren

AU - Nordentoft, Merete

AU - Mors, Ole

AU - Mortensen, Preben B

AU - Uher, Rudolf

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) and anxiety disorders have been proposed as precursors of bipolar disorder, but their joint and relative roles in the development of bipolar disorder are unknown.AimsTo test the prospective relationship of ADHD and anxiety with onset of bipolar disorder.METHOD: We examined the relationship between ADHD, anxiety disorders and bipolar disorder in a birth cohort of 2 409 236 individuals born in Denmark between 1955 and 1991. Individuals were followed from their sixteenth birthday or from January 1995 to their first clinical contact for bipolar disorder or until December 2012. We calculated incidence rates per 10 000 person-years and tested the effects of prior diagnoses on the risk of bipolar disorder in survival models.RESULTS: Over 37 394 865 person-years follow-up, 9250 onsets of bipolar disorder occurred. The incidence rate of bipolar disorder was 2.17 (95% CI 2.12-2.19) in individuals with no prior diagnosis of ADHD or anxiety, 23.86 (95% CI 19.98-27.75) in individuals with a prior diagnosis of ADHD only, 26.05 (95% CI 24.47-27.62) in individuals with a prior diagnosis of anxiety only and 66.16 (95% CI 44.83-87.47) in those with prior diagnoses of both ADHD and anxiety. The combination of ADHD and anxiety increased the risk of bipolar disorder 30-fold (95% CI 21.66-41.40) compared with those with no prior ADHD or anxiety.CONCLUSIONS: Early manifestations of both internalising and externalising psychopathology indicate liability to bipolar disorder. The combination of ADHD and anxiety is associated with a very high risk of bipolar disorder.Declaration of interestNone.

AB - BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) and anxiety disorders have been proposed as precursors of bipolar disorder, but their joint and relative roles in the development of bipolar disorder are unknown.AimsTo test the prospective relationship of ADHD and anxiety with onset of bipolar disorder.METHOD: We examined the relationship between ADHD, anxiety disorders and bipolar disorder in a birth cohort of 2 409 236 individuals born in Denmark between 1955 and 1991. Individuals were followed from their sixteenth birthday or from January 1995 to their first clinical contact for bipolar disorder or until December 2012. We calculated incidence rates per 10 000 person-years and tested the effects of prior diagnoses on the risk of bipolar disorder in survival models.RESULTS: Over 37 394 865 person-years follow-up, 9250 onsets of bipolar disorder occurred. The incidence rate of bipolar disorder was 2.17 (95% CI 2.12-2.19) in individuals with no prior diagnosis of ADHD or anxiety, 23.86 (95% CI 19.98-27.75) in individuals with a prior diagnosis of ADHD only, 26.05 (95% CI 24.47-27.62) in individuals with a prior diagnosis of anxiety only and 66.16 (95% CI 44.83-87.47) in those with prior diagnoses of both ADHD and anxiety. The combination of ADHD and anxiety increased the risk of bipolar disorder 30-fold (95% CI 21.66-41.40) compared with those with no prior ADHD or anxiety.CONCLUSIONS: Early manifestations of both internalising and externalising psychopathology indicate liability to bipolar disorder. The combination of ADHD and anxiety is associated with a very high risk of bipolar disorder.Declaration of interestNone.

KW - ADHD

KW - Bipolar disorder

KW - CHILD-BEHAVIOR CHECKLIST

KW - COHORT

KW - HIGH-RISK

KW - MENTAL-ILLNESS

KW - METAANALYSIS

KW - PEOPLE

KW - PREVALENCE

KW - PSYCHOPATHOLOGY

KW - SCHIZOPHRENIA

KW - anxiety disorders

KW - attention-deficit

KW - developmental psychopathology

KW - early identification of risk

KW - externalising disorders

KW - hyperactivity disorder

KW - internalizing disorders

UR - http://www.scopus.com/inward/record.url?scp=85065046241&partnerID=8YFLogxK

U2 - 10.1192/bjp.2018.111

DO - 10.1192/bjp.2018.111

M3 - Journal article

C2 - 29925436

VL - 213

SP - 555

EP - 560

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

SN - 0007-1250

IS - 3

ER -