Preben Bo Mortensen

Association Between Childhood Green Space, Genetic Liability, and the Incidence of Schizophrenia

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@article{6c50ef0dc6ac460cbcf5bc4f985800e6,
title = "Association Between Childhood Green Space, Genetic Liability, and the Incidence of Schizophrenia",
abstract = "Childhood exposure to green space has previously been associated with lower risk of developing schizophrenia later in life. It is unclear whether this association is mediated by genetic liability or whether the 2 risk factors work additively. Here, we investigate possible gene-environment associations with the hazard ratio (HR) of schizophrenia by combining (1) an estimate of childhood exposure to residential-level green space based on the normalized difference vegetation index (NDVI) from Landsat satellite images, with (2) genetic liability estimates based on polygenic risk scores for 19 746 genotyped individuals from the Danish iPSYCH sample. We used information from the Danish registers of health, residential address, and socioeconomic status to adjust HR estimates for established confounders, ie, parents' socioeconomic status, and family history of mental illness. The adjusted HRs show that growing up surrounded by the highest compared to the lowest decile of NDVI was associated with a 0.52-fold (95% confidence interval [CI]: 0.40 to 0.66) lower schizophrenia risk, and children with the highest polygenic risk score had a 1.24-fold (95% CI: 1.18 to 1.30) higher schizophrenia risk. We found that NDVI explained 1.45% (95% CI: 1.07 to 1.90) of the variance on the liability scale, while polygenic risk score for schizophrenia explained 1.01% (95% CI: 0.77 to 1.46). Together they explained 2.40% (95% CI: 1.99 to 3.07) with no indication of a gene-environment interaction (P = .29). Our results suggest that risk of schizophrenia is associated additively with green space exposure and genetic liability, and provide no support for an environment-gene interaction between NDVI and schizophrenia.",
author = "Kristine Engemann and Pedersen, {Carsten B{\o}cker} and Esben Agerbo and Lars Arge and B{\o}rglum, {Anders Dupont} and Christian Erikstrup and Ole Hertel and Hougaard, {David Michael} and McGrath, {John J} and Ole Mors and Mortensen, {Preben Bo} and Merete Nordentoft and Sabel, {Clive Eric} and Torben Sigsgaard and Constantinos Tsirogiannis and Vilhj{\'a}lmsson, {Bjarni J{\'o}hann} and Thomas Werge and Jens-Christian Svenning and Horsdal, {Henriette Thisted}",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.All rights reserved. For permissions, please email: journals.permissions@oup.com.",
year = "2020",
month = may,
day = "16",
doi = "10.1093/schbul/sbaa058",
language = "English",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Association Between Childhood Green Space, Genetic Liability, and the Incidence of Schizophrenia

AU - Engemann, Kristine

AU - Pedersen, Carsten Bøcker

AU - Agerbo, Esben

AU - Arge, Lars

AU - Børglum, Anders Dupont

AU - Erikstrup, Christian

AU - Hertel, Ole

AU - Hougaard, David Michael

AU - McGrath, John J

AU - Mors, Ole

AU - Mortensen, Preben Bo

AU - Nordentoft, Merete

AU - Sabel, Clive Eric

AU - Sigsgaard, Torben

AU - Tsirogiannis, Constantinos

AU - Vilhjálmsson, Bjarni Jóhann

AU - Werge, Thomas

AU - Svenning, Jens-Christian

AU - Horsdal, Henriette Thisted

N1 - © The Author(s) 2020. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2020/5/16

Y1 - 2020/5/16

N2 - Childhood exposure to green space has previously been associated with lower risk of developing schizophrenia later in life. It is unclear whether this association is mediated by genetic liability or whether the 2 risk factors work additively. Here, we investigate possible gene-environment associations with the hazard ratio (HR) of schizophrenia by combining (1) an estimate of childhood exposure to residential-level green space based on the normalized difference vegetation index (NDVI) from Landsat satellite images, with (2) genetic liability estimates based on polygenic risk scores for 19 746 genotyped individuals from the Danish iPSYCH sample. We used information from the Danish registers of health, residential address, and socioeconomic status to adjust HR estimates for established confounders, ie, parents' socioeconomic status, and family history of mental illness. The adjusted HRs show that growing up surrounded by the highest compared to the lowest decile of NDVI was associated with a 0.52-fold (95% confidence interval [CI]: 0.40 to 0.66) lower schizophrenia risk, and children with the highest polygenic risk score had a 1.24-fold (95% CI: 1.18 to 1.30) higher schizophrenia risk. We found that NDVI explained 1.45% (95% CI: 1.07 to 1.90) of the variance on the liability scale, while polygenic risk score for schizophrenia explained 1.01% (95% CI: 0.77 to 1.46). Together they explained 2.40% (95% CI: 1.99 to 3.07) with no indication of a gene-environment interaction (P = .29). Our results suggest that risk of schizophrenia is associated additively with green space exposure and genetic liability, and provide no support for an environment-gene interaction between NDVI and schizophrenia.

AB - Childhood exposure to green space has previously been associated with lower risk of developing schizophrenia later in life. It is unclear whether this association is mediated by genetic liability or whether the 2 risk factors work additively. Here, we investigate possible gene-environment associations with the hazard ratio (HR) of schizophrenia by combining (1) an estimate of childhood exposure to residential-level green space based on the normalized difference vegetation index (NDVI) from Landsat satellite images, with (2) genetic liability estimates based on polygenic risk scores for 19 746 genotyped individuals from the Danish iPSYCH sample. We used information from the Danish registers of health, residential address, and socioeconomic status to adjust HR estimates for established confounders, ie, parents' socioeconomic status, and family history of mental illness. The adjusted HRs show that growing up surrounded by the highest compared to the lowest decile of NDVI was associated with a 0.52-fold (95% confidence interval [CI]: 0.40 to 0.66) lower schizophrenia risk, and children with the highest polygenic risk score had a 1.24-fold (95% CI: 1.18 to 1.30) higher schizophrenia risk. We found that NDVI explained 1.45% (95% CI: 1.07 to 1.90) of the variance on the liability scale, while polygenic risk score for schizophrenia explained 1.01% (95% CI: 0.77 to 1.46). Together they explained 2.40% (95% CI: 1.99 to 3.07) with no indication of a gene-environment interaction (P = .29). Our results suggest that risk of schizophrenia is associated additively with green space exposure and genetic liability, and provide no support for an environment-gene interaction between NDVI and schizophrenia.

U2 - 10.1093/schbul/sbaa058

DO - 10.1093/schbul/sbaa058

M3 - Journal article

C2 - 32415773

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

ER -