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Páll Karlsson

Increased peptidergic fibers as a potential cutaneous marker of pain in diabetic small fiber neuropathy

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Standard

Increased peptidergic fibers as a potential cutaneous marker of pain in diabetic small fiber neuropathy. / Karlsson, Pall; Provitera, Vincenzo; Caporaso, Giuseppe; Stancanelli, Annamaria; Saltalamacchia, Anna Maria; Borreca, Ilaria; Manganelli, Fiore; Santoro, Lucio; Jensen, Troels Staehelin; Nolano, Maria.

I: Pain, Bind 162, Nr. 3, 03.2021, s. 778-786.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Karlsson, P, Provitera, V, Caporaso, G, Stancanelli, A, Saltalamacchia, AM, Borreca, I, Manganelli, F, Santoro, L, Jensen, TS & Nolano, M 2021, 'Increased peptidergic fibers as a potential cutaneous marker of pain in diabetic small fiber neuropathy', Pain, bind 162, nr. 3, s. 778-786. https://doi.org/10.1097/j.pain.0000000000002054

APA

Karlsson, P., Provitera, V., Caporaso, G., Stancanelli, A., Saltalamacchia, A. M., Borreca, I., Manganelli, F., Santoro, L., Jensen, T. S., & Nolano, M. (2021). Increased peptidergic fibers as a potential cutaneous marker of pain in diabetic small fiber neuropathy. Pain, 162(3), 778-786. https://doi.org/10.1097/j.pain.0000000000002054

CBE

Karlsson P, Provitera V, Caporaso G, Stancanelli A, Saltalamacchia AM, Borreca I, Manganelli F, Santoro L, Jensen TS, Nolano M. 2021. Increased peptidergic fibers as a potential cutaneous marker of pain in diabetic small fiber neuropathy. Pain. 162(3):778-786. https://doi.org/10.1097/j.pain.0000000000002054

MLA

Vancouver

Karlsson P, Provitera V, Caporaso G, Stancanelli A, Saltalamacchia AM, Borreca I o.a. Increased peptidergic fibers as a potential cutaneous marker of pain in diabetic small fiber neuropathy. Pain. 2021 mar;162(3):778-786. https://doi.org/10.1097/j.pain.0000000000002054

Author

Karlsson, Pall ; Provitera, Vincenzo ; Caporaso, Giuseppe ; Stancanelli, Annamaria ; Saltalamacchia, Anna Maria ; Borreca, Ilaria ; Manganelli, Fiore ; Santoro, Lucio ; Jensen, Troels Staehelin ; Nolano, Maria. / Increased peptidergic fibers as a potential cutaneous marker of pain in diabetic small fiber neuropathy. I: Pain. 2021 ; Bind 162, Nr. 3. s. 778-786.

Bibtex

@article{c3d485ff44914046bcc783cb341a7322,
title = "Increased peptidergic fibers as a potential cutaneous marker of pain in diabetic small fiber neuropathy",
abstract = "Diabetic polyneuropathy (DPN) is a common complication to diabetes and is often associated with neuropathic pain. The mechanisms underlying development and maintenance of painful DPN are largely unknown and quantification of intraepidermal nerve fiber density (IENFD) from skin biopsy, one of the neuropathological gold standard when diagnosing DPN, does not differentiate between patients with and without pain. Identification of possible pain pathophysiological biomarkers in patients with painful DPN may increase our knowledge of mechanisms behind neuropathic pain. Animal models of painful DPN have been shown to have an increased density of peptidergic nerve fibers (Substance P (SP) and Calcitonin-gene related peptide (CGRP)). In this study we performed a detailed skin biopsy analysis in a well-characterized group of DPN patients with primarily small fiber involvement, with and without pain and in healthy controls and test for correlation between skin biopsy findings and pain intensity and quantitative sensory testing (QST). We found that while there was no difference in IENFD using PGP 9.5 between patients with and without pain, patients with pain had increased density of dermal peptidergic fibers containing SP and CGRP compared to patients with painless DPN and healthy controls. Peptidergic nerve fiber density correlated with pain ratings in patients with pain (R=0.33; p=0.019) but not with QST results. Here we show, for the first time in humans, an increased density of dermal peptidergic fibers in painful DPN. These findings provide new insight in the pathophysiological mechanisms of pain in diabetes and opens the research towards new therapeutic targets.",
author = "Pall Karlsson and Vincenzo Provitera and Giuseppe Caporaso and Annamaria Stancanelli and Saltalamacchia, {Anna Maria} and Ilaria Borreca and Fiore Manganelli and Lucio Santoro and Jensen, {Troels Staehelin} and Maria Nolano",
year = "2021",
month = mar,
doi = "10.1097/j.pain.0000000000002054",
language = "English",
volume = "162",
pages = "778--786",
journal = "Pain",
issn = "0304-3959",
publisher = "IASP Press",
number = "3",

}

RIS

TY - JOUR

T1 - Increased peptidergic fibers as a potential cutaneous marker of pain in diabetic small fiber neuropathy

AU - Karlsson, Pall

AU - Provitera, Vincenzo

AU - Caporaso, Giuseppe

AU - Stancanelli, Annamaria

AU - Saltalamacchia, Anna Maria

AU - Borreca, Ilaria

AU - Manganelli, Fiore

AU - Santoro, Lucio

AU - Jensen, Troels Staehelin

AU - Nolano, Maria

PY - 2021/3

Y1 - 2021/3

N2 - Diabetic polyneuropathy (DPN) is a common complication to diabetes and is often associated with neuropathic pain. The mechanisms underlying development and maintenance of painful DPN are largely unknown and quantification of intraepidermal nerve fiber density (IENFD) from skin biopsy, one of the neuropathological gold standard when diagnosing DPN, does not differentiate between patients with and without pain. Identification of possible pain pathophysiological biomarkers in patients with painful DPN may increase our knowledge of mechanisms behind neuropathic pain. Animal models of painful DPN have been shown to have an increased density of peptidergic nerve fibers (Substance P (SP) and Calcitonin-gene related peptide (CGRP)). In this study we performed a detailed skin biopsy analysis in a well-characterized group of DPN patients with primarily small fiber involvement, with and without pain and in healthy controls and test for correlation between skin biopsy findings and pain intensity and quantitative sensory testing (QST). We found that while there was no difference in IENFD using PGP 9.5 between patients with and without pain, patients with pain had increased density of dermal peptidergic fibers containing SP and CGRP compared to patients with painless DPN and healthy controls. Peptidergic nerve fiber density correlated with pain ratings in patients with pain (R=0.33; p=0.019) but not with QST results. Here we show, for the first time in humans, an increased density of dermal peptidergic fibers in painful DPN. These findings provide new insight in the pathophysiological mechanisms of pain in diabetes and opens the research towards new therapeutic targets.

AB - Diabetic polyneuropathy (DPN) is a common complication to diabetes and is often associated with neuropathic pain. The mechanisms underlying development and maintenance of painful DPN are largely unknown and quantification of intraepidermal nerve fiber density (IENFD) from skin biopsy, one of the neuropathological gold standard when diagnosing DPN, does not differentiate between patients with and without pain. Identification of possible pain pathophysiological biomarkers in patients with painful DPN may increase our knowledge of mechanisms behind neuropathic pain. Animal models of painful DPN have been shown to have an increased density of peptidergic nerve fibers (Substance P (SP) and Calcitonin-gene related peptide (CGRP)). In this study we performed a detailed skin biopsy analysis in a well-characterized group of DPN patients with primarily small fiber involvement, with and without pain and in healthy controls and test for correlation between skin biopsy findings and pain intensity and quantitative sensory testing (QST). We found that while there was no difference in IENFD using PGP 9.5 between patients with and without pain, patients with pain had increased density of dermal peptidergic fibers containing SP and CGRP compared to patients with painless DPN and healthy controls. Peptidergic nerve fiber density correlated with pain ratings in patients with pain (R=0.33; p=0.019) but not with QST results. Here we show, for the first time in humans, an increased density of dermal peptidergic fibers in painful DPN. These findings provide new insight in the pathophysiological mechanisms of pain in diabetes and opens the research towards new therapeutic targets.

U2 - 10.1097/j.pain.0000000000002054

DO - 10.1097/j.pain.0000000000002054

M3 - Journal article

C2 - 32833793

VL - 162

SP - 778

EP - 786

JO - Pain

JF - Pain

SN - 0304-3959

IS - 3

ER -